Ovarian Agenesis Research Articles

A novel de novo synonymous variant in GREB1L impacts the mRNA splicing associated with aplasia of the urogenital system.

GREB1-like retinoic acid receptor coactivator (GREB1L) gene is associated with autosomal dominant renal hypodysplasia/aplasia 3 (RHDA3) and deafness, autosomal dominant 80 (DFNA80). Among the GREB1L variants reported, most of them are missense or frameshift, while no pathogenic synonymous variants have been recorded. Classical theory paid little attention to synonymous variants and classified it as nonpathogenic; however, recent studies suggest that the variants might be equally important. Here, we report a 7-year-old girl with new symptoms of clitoromegaly, uterovaginal, and ovarian agenesis as well as right kidney missing. A novel de novo GREB1L synonymous variant (NM_001142966: c.4731C>T, p.G1577=) was identified via whole exome sequencing. The variant was predicted to be disease-causing through in silico analysis and was classified as likely pathogenic. Minigene splicing assays confirmed a 6 bp deletion in mutant cDNA comparing with the wild type, leading to two amino acids lost in GREB1L protein. Secondary and tertiary structure modeling showed alterations in protein structure. Our finding reveals a novel GREB1L variant with a new phenotype of urogenital system and is the first to report a pathogenic synonymous variant in GREB1L which affects mRNA splicing, suggesting synonymous variants cannot be ignored in prenatal diagnosis and genetic counseling.

Mesenteric cyst in a newborn. A case report

We present a case report of a 1.5-month-old infant admitted to the Department of Paediatric Surgery on an elective basis in order to diagnose and treat an abdominal lesion identified in ultrasound examination during the prenatal period. Computed tomography with contrast of the abdominal cavity and pelvis showed a large abdominal cyst measuring 11 × 8 × 7 cm. Consequently, the child was referred for surgery. During the procedure, the cyst was completely dissected. Outside the abdominal cavity, it was decompressed from the blood-serous fluid. Intraoperatively, intestinal malrotation and right ovarian agenesis were additionally diagnosed. The material for histopathological examination was handed over in full. Microscopically, mesenteric lymphangioma was diagnosed.

Ectopic Pregnancy in a Patient with Ipsilateral Ovarian Agenesis

Ectopic Pregnancy in a Patient with Ipsilateral Ovarian Agenesis

078 A rare case of Mayer-Rokitansky-Küster-Hauser syndrome associated with bilateral ovarian agenesis in a normal karyotypic female

Objective: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the second more common cause of primary amenorrhea resulting from congenital absence of the vagina and agenesis or hypoplasia of the Mullerian (paramesonephric) ducts. Patients with MRKH syndrome have normal functioning ovaries with normal 46, XX karyotype and undergo puberty. On the contrary bilateral gonadal agenesis is a rare cause of hypergonadotropic hypogonadism. Combination of these two pathologic entities is sporadically reported in the literature. We present an extremely rare case of primary amenorrhea with MRKH syndrome (U5bC4V4 by ESHRE classification) and coexisting bilateral ovarian agenesis.

Case Series of the Antenatal and Early Postnatal Adnexal Torsion: Solved Mystery of Ovarian Absence?

Background: Antenatal and early postnatal adnexal torsion are rare complications of fetal ovarian cysts that typically result in loss of the affected ovary. These cases may be undiagnosed and present as unilateral ovarian absence later in life. Here, “absence” may refer to instances of “true” embryological ovarian agenesis, or prior autoamputation leading to ovarian absence. The latter etiology likely accounts for the majority of cases. While cyst size has been demonstrated to be a risk factor for torsion, the contribution of other prenatal and maternal factors in predicting antenatal or early postnatal ovarian torsion remain unclear.

The Coexistence of Gonadal Dysgenesis With Mayer-rokitansky-küster-hauser Syndrome, and Dandy-Walker Variant

Background: Gonadal dysgenesis, the most common cause of primary amenorrhea, is characterized by absent or underdeveloped ovaries. Although the coexistence of gonadal dysgenesis and Mayer-Rokitansky-Küster-Hauser (MRKH) has been reported, it is still quite infrequent. To the extent that authors searched, just one study reported the association between Rokitansky sequence and Dandy-Walker malformation. Clinical Presentation and Intervention: We aimed to report a case with gonadal dysgenesis, MRKH, and the Dandy-Walker variant. In this care report, the authors reported a 15-year-old girl with primary amenorrhea and underdeveloped secondary sexual properties. Her karyotype was 46, XX. The abdominopelvic MRI without contrast demonstrated bilateral ovarian agenesis and no uterus or cervix. Vagina was normal in length. Brain MRI was consistent with the Dandy-Walker variant. Conclusion: Although some affected chromosomal regions have been identified, further genetic analyses should be performed to elucidate the probable association between these anomalies.

Complete Androgen Insensitivity Syndrome: Diagnosis and Psychological Impact in Adolescence, A Case Report

This case report illustrates the case of complete androgen insensitivity syndrome (CAIS) which is a rare form of sexual development disorders (DSD). Complex critical thinking is needed for pathophysiology of primary amenorrhea causes and sex chromosomes differences of sexual development, such as primary ovarian failure, Mullerian Agenesis or disorders with abnormal androgen synthesis or response. This is a phenotypically female who presented with primary amenorrhea at the age of 19 years old. Normal levels of thyroid function test, serum prolactin and follicle stimulating hormone ruled out hypothyroidism, hyperprolactinemia, and primary ovarian failure. Magnetic resonance imaging showed absence of uterus, fallopian tubes, ovaries, but presence of proximal 1/3rd of the vagina. There is a single testis in the left inguinal region with unknown status of spermatogenesis. The chromosomal analysis revealed 46, XY karyotype conveying the patient is genotypically male. The testis-determining factor (TDF) test or sex-determining region Y (SRY) protein for male sex determination was not done. Similar presentation of primary amenorrhea diagnosis of CAIS was made to her 18-year-old sister. Women with CAIS are vulnerable to various psychological conditions caused by the appalling fact of being genotypically male when they have been raised female all their life. The gender confusion, reproductive issues and how others perceive them in the outside world require sensitive support. Hence, accentuate the need to address the emotional, psychological, and psychiatric vulnerabilities in issues pertaining to relationships, infertility and conception.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S12

86. Unilateral Ovarian Agenesis: A Systematic Review of the Literature and Report of Two Cases

<h3>Background</h3> Ovarian agenesis (OA) is a rare and often incidental finding. Noncompeting embryological, vascular, and mechanical hypotheses comprise possible etiologies, though exact predisposing factors remain unknown. Here, we report two cases of unilateral OA (UOA) and results from the first systematic review. <h3>Case</h3> A 15-year-old girl with history of nephrolithiasis and pelvic pain presented for diagnostic laparoscopy due to suspected endometriosis. Three prior ultrasounds demonstrated normal-appearing ovaries with right corpus luteum cyst. Surgery revealed normal round ligaments, normal postpubertal uterus, right fallopian tube with paratubal cyst and enlarged right ovary. The left ovary, left distal fallopian tube, and left uteroovarian ligament were absent. Multiple peritoneal biopsies were positive for endometriosis. Right paratubal cyst was removed. Postoperative MRI did not identify a heterotopic left ovary. The second patient is a 30-year-old G3P1011 with a history of genital chlamydia, prior laparotomy to retrieve a foreign body, and right tubal ectopic pregnancy treated medically two years prior. She presented with severe abdominal pain and positive pregnancy test. An ultrasound demonstrated normal bilateral ovaries and a cystic right adnexal structure concerning for ectopic pregnancy. Patient elected for unilateral salpingectomy. Operative findings were significant for bleeding gestational sac extruding from the broad ligament. The left ovary and round ligaments were normal, but the right ovary, distal fallopian tube and infundibulopelvic ligament were absent. In both cases a second attending physician was consulted intraoperatively to confirm the absent ovary. <h3>Comments</h3> We conducted a systematic literature review on OA on 6/29/20 using Cochrane Library, Medline, Embase, Google Scholar, Scopus, and Web of Science databases, resulting in 66 relevant articles with 85 cases of OA. Descriptive statistics and univariate analysis were performed in SAS and Excel. The average age of diagnosis was 23.8 years. Ultrasound was the most common imaging technique (49%), and the majority of cases had laparoscopic surgery (65%). Of the cases that mentioned pre-operative imaging results, 13/51 did not mention ovarian anomalies. Abdominal/pelvic pain (27%), and infertility/subfertility (21%) were the most common presenting symptoms. UOA was the most common type of OA (96%) with both sides equally affected. Some ipsilateral fallopian tube absence was present in 81% cases. Approximately 26% of cases had concomitant uterine abnormalities, while 20% had renal abnormalities. These findings are important as they may guide workup and follow-up for females if ovarian agenesis or heterotopic ovarian location is diagnosed.

Infertility in Female Dromedary Camels

This review discusses the most common infertility-related reproductive disorders in female dromedaries. Four major categories are identifed, namely, congenital, functional, pathological and management disorders. Congenital causes comprise ovarian agenesis, mesonephric duct segmental aplasia, endometrial agenesis, double cervix/vagina, imperforated hymen, vulvar atresia, and intersex. Functional causes cover ovarian inactivity, overgrown follicle, and ovulation failure. Pathological causes include ovarian hydrobursitis, hydrosalpinx and pyosalpinx, clinical and subclinical endometritis, hydrometra and pyometra, vaginal and cervical adhesions, and neoplasms. Management causes involve mating errors, use of traditional management systems, improper herder/camel ratio, and inadequate managerial experience. Pathological lesions and management errors are the main causes of female camel infertility. There are several effective protocols for the treatment of endometritis that offer a resilient prognosis. Ovarian hydrobursitis and vaginal adhesion are serious conditions and require appropriate preventive measures because treatment procedures are diffcult and the prognosis poor. Enhanced management practices are essential in order to increase the reproductive effciency of dromedary herds.

Foetal wastages and some gross reproductive abnormalities in small ruminants slaughtered at Dogarawa slaughter slab Zaria, Kaduna State

Introduction: Slaughtering of pregnant animals resulting in foetal wastages abound in many countries of the world. The practice of slaughtering of gravid animals in Nigeria is largely due to lower economic standards of the citizens. This study was to establish the nature and incidence of reproductive abnormalities and foetal wastages in small ruminants observed at Dogarawa slaughter slab Zaria, Kaduna state. Methods: Ante-mortem and post-mortem examinations of the genital tract of slaughtered small ruminants were conducted using visual examination, palpation and incision. A total of 1695 animals slaughtered on weekends (Saturdays and Sundays) within the months of August and September 2019 were examined. A total of 1158 bucks, 264 does, 111 ewes and 162 rams were slaughtered. Values obtained were presented in percentages using Microsoft excel, 2016. Results: A total of 52 foetal wastages were recorded (71.15% in sheep and 28.85% in goats). Abnormalities of the ovaries observed include ovarian hypertrophy (6.25%), the cystic follicle (12.5%) and unilateral ovarian agenesis (6.25%), which were detected at post-mortem examination. Abnormalities of the uterus observed were pyometra (6.25%), hydrometra (6.25%), metritis (12.5%) and uterine atrophy (6.25%). Supernumerary teats (25%) and mastitis (18.75%) were also observed. Ante-mortem and post-mortem gross pathological conditions of the male reproductive tract revealed; cryptorchidism (41.18%), paraphimosis (11.26%), testicular hypoplasia (5.88%), epididymitis (29.41%) and balanoposthitis (11.76%). Significance: The results from this study revealed various types of reproductive anomalies in animals brought to slaughter. The study also revealed the practice of slaughtering of pregnant animals resulting in foetal wastages.

The Desaturase Gene Nlug-desatA2 Regulates the Performance of the Brown Planthopper Nilaparvata lugens and Its Relationship with Rice.

Insect desaturases are known to play an important role in chemical communication between individuals. However, their roles in insect growth, development and fecundity, and in regulating interactions of insects with plants, remain largely unknown. In this study, we explored the functions of Nlug-desatA2, a desaturase gene of the brown planthopper (BPH), Nilaparvata lugens (Stål). The RNA interference-based knockdown of Nlug-desatA2 decreased the ratio of monounsaturated fatty acids to saturated fatty acids, and the level of fatty acids and triglycerides in BPH. Nlug-desatA2-knockdown also reduced the food intake, body mass and fecundity of female BPH adults, and led to abdomen atrophy and ovarian agenesis. Nlug-desatA2-knockdown suppressed the transcription of TOR (target of rapamycin), Lpp (Lipophorin) and AKHR (adipokinetic hormone receptor) in female adults. Moreover, the corrected survival rate of BPH with Nlug-desatA2-knockdown fed an artificial diet was higher than the survival rate of those fed on rice plants. Higher levels of salicylic acid in rice infested by Nlug-desatA2-knockdown female BPH adults than in rice infested by control BPH may be the reason. These findings demonstrate that Nlug-desatA2 has an essential role in lipid metabolism and is involved in the food intake, survival, development and fecundity of BPH. In addition, this gene is likely involved in regulating the responses of rice to BPH infestation.

Agenesia ovariana unilateral em gata

Anomalias reprodutivas em fêmeas domésticas são de rara ocorrência e caracterizam-se na grande maioria dos casos pela ausência de sintomatologia clínica que possa ser percebida pelos proprietários, dessa maneira o diagnóstico ocorre muitas vezes de forma incidental durante OSH, necropsia ou celiotomia exploratória. Este artigo descreve o achado incidental de agenesia ovariana unilateral direita em gata SRD submetida a OSH em programa de castração solidária. Na ocasião, não foram realizados exames complementares pré-cirúrgicos, estando a avaliação do animal restrita apenas a exame físico geral e palpação abdominal. A abordagem foi realizada por meio de acesso mediano ventral. Após a exposição do corno uterino esquerdo foi constatada inexistência do ovário esquerdo, que foi confirmada mediante palpação cranial do complexo arteriovenoso ovariano (CAVO) até a superfície renal. Não houveram dificuldades na realização das manobras de hemostasia, no entanto, a ausência de exames de imagem pode aumentar o risco cirúrgico, sobretudo para profissionais ou estudantes inexperientes. Apesar de ser uma condição de simples resolução cirúrgica, deve-se evitar demasiada e brusca tração do CAVO devido ao risco de complicações decorrentes de sua ruptura.

The rarely seen congenital anomaly in a queen: Unilateral ovarian agenesis

Congenital malformations of the reproductive system are rarely encountered in queens and etiology is not known precisely. Agenesis of the ovary is one of the congenital anomalies and usually found incidentally during laparotomy operations. In this case, a 2-year-old female cat referred to the clinic for ovariohysterectomy is described. Before anesthesia and surgery, a routine examination was performed. In physical examinations and results of blood samples did not reveal any problem for the operation. After the pre-operative process, ovariohysterectomy was performed. Ovary and the uterine horn were identified on the right-side. However, only the uterine horn without any abnormality was detected on the left-side. The cat was diagnosed with unilateral ovarian agenesis. Then, a blood sample was taken to determine serum steroid hormone levels. Serum estradiol and progesterone levels were measured as 18 pg/ml and 1.4 ng/ml, respectively. As a conclusion, unilateral ovarian agenesis that is incidentally detected the laparotomy procedures were no adverse effect on sexual activity in queens.

Unilateral ovarian and fallopian tube agenesis

Unilateral ovarian and fallopian tube agenesis

Ovarian agenesis and Mullerian duct dysgenesis in a karyotypically normal (46, XX) pre-pubertal girl with aberrant cognition: A case report and literature review

Introduction: Phenotypically normal pre-pubertal girl presenting with only a little delay in onset of puberty and emotional lability is seldom thought to be suffering from a serious underlying congenital defect at the outset. Amongst different congenital causes for such presentation, Mayer-Rokitansky-Kuster-Hauser syndrome is scarcely reported so far. This condition usually manifests with primary amenorrhoea and infertility in phenotypically and karyotypically normal 46, XX females. In the atypical form of this syndrome additional congenital malformations involving mostly renal and skeletal systems are noticed along with Mullerian dust dysgenesis. Case description: A 12-year-old girl attended the adolescent clinic with complaints of generalised weakness, inadequate height gains and emotional lability. Initial clinical examination recorded genu valgus and absence of pubertal growth spurt. Subsequently, blood hormonal assay depicted hypergonadotropic hypogonadism state. Bilateral absence of gonads and Mullerian duct anomalies were detected further in an otherwise normal female karyotype (46, XX). No additional structural anomaly noticed. Developmental quotient assessment suggested intellectual disability. Conclusions: A stepwise approach incidentally revealed a rare condition like atypical form of MRKH syndrome where bilateral gonadal agenesis and Mullerian duct dysgenesis were present but without any additional congenital malformations. Assessment of cognitive function in such cases should be sought for. Early detection of such rare case helps in building the emotional support of the family members in advance, long before the time when the patient might eventually present with primary amenorrhoea or infertility.

Agenesia unilateral do corno uterino e ovário direito em gata

Objetivou-se descrever o achado de agenesia uterina e ovariana em gata submetida a procedimento de mastectomia total e ovariosalpingohisterectomia para tratamento de hiperplasia fibroepitelial mamária felina. O presente trabalho descreveu o caso de um felino, fêmea, sem padrão de raça definido, sete meses de idade com histórico de aumento de volume mamário após administração de uma dose de contraceptivo acetato de medroxiprogesterona. De acordo com a anamnese e o exame físico foi estabelecido o diagnóstico de hiperplasia fibroepitelial felina. Para o tratamento foi instituído a mastectomia total e a ovariosalpingohisterectomia (OSH). Durante o ato operatório constatou-se a ausência do corno uterino e ovário direito. Esse tipo de malformação pode passar despercebido já que o animal pode não apresentar alterações clínicas e demonstrar comportamento éstrico normal, sendo na maioria das vezes um achado incidental e assume importância, principalmente, pela possiblidade da ocorrência de anomalias de órgãos distintos com a mesma origem embriológica.

A Study of Congenital abnormalities of the Non-Pregnant genitalia in cows: 1. Ovaries and uterine tubes

The current study was conducted to detect the pathological conditions of the congenital abnormalities of ovaries and uterine tubes of cows slaughtered at the abattoir in Sulaimani, Kurdistan Region-Iraq. The pathological conditions were subjected to a macroscopic and microscopic examination of 404 samples of female genitalia collected from slaughtered non-pregnant cows, during the period from February to September 2014 from the Qaragol slaughterhouse twice a week. The organs were observed macroscopically for pathological abnormalities and stained tissues with Haematoxylin and eosin. They were examined under microscope for determination of the type of lesion present in the organ. Among the 404 genitalia samples collected from the non-pregnant animals, 206 (51%) were found without gross pathological abnormalities and (with cyclic activity) and the 30 (7.43%) samples were found with gross congenital abnormalities of ovaries and uterine tubes. Detected lesions in the ovaries and uterine tubes included paraovarian cysts 3.21%, ovarian hypoplasia 1.98%, ovarian agenesis 0.50%, aplasia of uterine tube 0.99%, segmental aplasia of uterine tube 0.50% and accessory of uterine tube 0.25%. The histopathological sections of paraovarian cyst showed a single layer of tubal-type ciliated cuboidal epithelial cells resting on a thin layer of fibrous tissue, the section of ovarian hypoplasia showed lack of ovarian follicles and oocytes, which instead are replaced by bands fibrovascular stroma. The partial duplication of uterine tube was observed, which was about 6 cm from the uterotubal junction and extended distally for a distance of 4 cm that was found in right side of tracts. It was concluded that the paraovarian cysts were the most common congenital abnormalities of ovaries and uterine tubes in non-pregnant cows.

Use of infragluteal folds as a full‐thickness skin graft donor site for construction of the neovagina in cases of Mullerian agenesis

The aims of this study were to present the results of using infragluteal folds as a skin graft donor site in cases of Mullerian agenesis undergoing full-thickness skin graft vaginoplasty and to evaluate the outcomes of the surgical technique. Demographics and clinical parameters of 24 consecutive Mullerian agenesis patients refusing any dilatational procedure and undergoing neovaginal construction using infragluteal folds skin grafts from May 2004 to July 2015 were analyzed. The mean age of the patients was 21.5 ± 5.7 years. Five patients had nonfunctional rudimentary uterus, one patient had unilateral ovarian agenesis, one patient had unilateral renal agenesis, and one had undergone a previous vaginoplasty. There were no serious complications needing surgical or medical intervention. The depth of the neovagina in patients with a follow-up period of more than 6 months (n = 17) varied from 7 to 12 cm. Of these patients, the sexually active ones (n = 8) did not complain of dyspareunia or vaginal dryness during sexual intercourse. The resulting scars were satisfactory and acceptable for all patients. It has been our practice to use infragluteal folds as a skin graft donor site for full-thickness skin graft vaginoplasty. We believe that the results of this study demonstrate that this area is versatile and an excellent alternative to the groins and lower abdomen. Further clinical and histomorphological investigations are necessary for strong statements and results.

A Pathological Study of Ovarian Abnormalities in Slaughtered NonPregnant Cows in Sulaimani Province.

The current study was conducted to address the pathological conditions of ovaries of cows&#x0D; slaughtered at the abattoir in Sulaimani province, Kurdistan Region-Iraq. Among the 404&#x0D; genitalia samples collected from the non-pregnant animals, 206 (51%) were found without&#x0D; gross pathological abnormalities (with cyclic activity) and the remaining&#x0D; 120(29.70%)samples were found with gross pathological abnormalities of ovaries. The&#x0D; ovaries exhibited the highest percentage of lesions 29.70%. Detected ovarian lesions&#x0D; included follicular cyst 10.89%, cystic corpus luteum 5.44%, mild ovariobursal adhesions&#x0D; 4.45 %, sever ovariobursal adhesion 0.25%, paraovarian cysts 3.22%, ovarian hypoplasia&#x0D; 1.98%, ovarian hemorrhage (hemorrhagic cystic corpus luteum) 1.48%, luteal cyst 1.24%,&#x0D; ovarian agenesis 0.50% and ovarian tumor (Gonadoblastoma) 0.25%. Histopathological&#x0D; examinations exhibited that the follicular cysts were lined by several layers of granulosa&#x0D; and theca cell, while the luteal cysts had follicular granulsa and the theca cells with marked&#x0D; luteinization of cytoplasm. Microscopically, the ovarian hypoplasia showed lack of&#x0D; ovarian follicles and oocytes, while the cavities of paraovarian cysts were lined by a single&#x0D; layer of cuboidal epithelial cells, and the hemorrhagic cyst showed scattered hemorrhagic&#x0D; spots close to the lumen and luteinized of granulosa and theca cells layers of cystic wall.&#x0D; Histopathologically, the ovarian gonadoblastoma (Dysgenentic gonadoma) was&#x0D; characterized by dual population of germ cell tumor and sex-cord stromal tumor and this&#x0D; observation has not been recorded in Iraq previously. It was concluded that ovarian&#x0D; abnormalities constitutes an percentage 0f 29.70%. And ovarian gonadoblastoma was&#x0D; firstly recorded in this study in Iraq.

Ovarian and Uterine Horn Agenesis Accompanied by Ectopic Fetal Mummifcation in Canine

Background: The uterine horn agenesis or aplasia is a rare anomaly consisting of absence or incomplete development of the paramesonephric ducts that origin the uterine horns. This change occurs during fetal formation and may occur concomitantly to agenesis of the ovary and/or ipsilateral kidney. The extra-uterine pregnancy consists of fetal growth outside the uterine cavity and can occur as a tubal or abdominal pregnancy. We report here the case of a 7-years-old mix breed dog, attended at the Veterinary Hospital of the Federal University of Mato Grosso, with accidental diagnosis of agenesis of uterine horn and ovaries and ectopic fetal mummifcation.Case: A 7-years-old mix breed dog, not spayed, was attended at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT), complaining of mucous bloody vaginal discharge. The patient had regular estrus and was multiparous. There was no mating history in the last estrus neither trauma over the past months. In previous pregnancies the patientpresented eutocic labors. On physical examination the dog showed apathy although it was alert, pale mucous membranes, presence of perivulvar blackish secretion and discreet abdominal enlargement. As preoperative exams, a complete blood count, liver and renal function (serum creatinine and alanine aminotransferase) were performed. It has also performedthe abdominal ultrasound examination, which revealed the presence of uterus flled with hypoechoic luminal content and a thickened and irregular wall. The patient was referred to therapeutic ovariohysterectomy (OHE). After anesthesia and antisepsis, the access to the abdominal cavity was made, where there was a mummifed fetus with approximately 15.5 cmfrom neck to tail set, equivalent to 57 days of gestation. After removal of the papyraceus fetus, the uterus was found and then, when exposed, there was only the left uterine horn flled by content and ovarie, both were removed. After inspection, the synthesis of the abdominal cavity was carried out as the routine. During the postoperative period, the patient had no complications or other clinical signs similar to those observed in the initial presentation. Antibiotic (enrofloxacin 5 mg/kg every 12h), analgesic (dipyrone 20 mg/kg every 8 h) and non-steroidal anti-inflammatory (meloxicam 0.2 mg/kg every 24 h) were prescribed. The fetus and uterus were sent to the Veterinary Pathology UFMT Laboratory (PVL-HOVET).The fetus was covered by omentum and fat. After the initial incision, there was a hard fbrous capsule surrounding the mummifed fetus. There were no recent signs of rupture or scarring resulting from previous trauma in the uterus. Its size was 15x4.8x2.8 cm and it was flled out with mucus bloody brownish secretion (pyometra). Microscopically, had purulent inflammatory infltrate, diffuse and severe in mucosa and submucosa associated with cell debris and moderate hyperplasia glands containing microabscesses inside.Discussion: Reports of extra-uterine fetal mummifcation in dogs and cats are scarce. Even being reported infrequently in dogs if congenital uterine and ovarian abnormalities are found during surgery, a detailed inspection of the abdominal cavity should be performed in order to rule out the possible presence of the ipsilateral ovary. Even with the lack of specifc clinical signs, fetal ectopy can be diagnosed through a detailed clinical examination and image exams. Exploratory laparotomy can be used as a diagnostic and therapeutic tool, since the treatment is the excision of ectopic tissue and OHE in cases of uterine rupture.Keywords: aplasia, fetus, mummifcation, unicornuate uterus.