Outstanding Transparency Research Articles

Defect passivation engineering for achieving 4.29% light utilization efficiency MA-free wide-bandgap semi-transparent perovskite solar cells

Wide-bandgap perovskite materials are a great candidate for semitransparent perovskite solar cells (ST-PSCs) due to their tunable bandgap, outstanding transparency, and excellent photovoltaic performance. Though Br-rich perovskite can widen the bandgap, Br influences the crystallization dynamic speed leaving small perovskite grain sizes and high defects. Surface passivation engineering has been one of the best choices to suppress defects caused by the rapid crystallization of Br-rich perovskites. Herein, we applied MA-free perovskite as a light absorber because of the erratic thermal aging of MA-containing perovskites and selected phenethylammonium iodide (PEAI) and 4-trifluoro phenylethylammonium iodide (CF3PEAI) as passivation materials for improving the performance of opaque PSCs and ST-PSCs. Consequently, CF3PEA possesses a larger dipole moment. It has been demonstrated to exhibit a stronger binding energy with the substrate than PEA by density functional theory (DFT) calculations. This enhanced molecular interaction underpins the performance improvements in our solar cells, which manifests as an inverted planar structure opaque PSCs with 1.78 eV bandgap achieve a power conversion efficiency (PCE) of 17.09 % with excellent stability. A PCE of 17.17 % with 25 % average visible-light transmittance (AVT) and 4.29 % light utilization efficiency (LUE) of ST-PSCs is achieved by further optimizing the fabrication process of the buffer layer for protecting the perovskites from the damage of ITO sputter. Meanwhile, a four-terminal tandem solar cell with ST-PSC and silicon-based passivated emitter rear cell (PERC) obtains a PCE of 26.28 %. This work provides a feasible way to fabricate high-performance ST-PSCs with limited materials and preparation conditions.

Polymerizable deep eutectic solvent-gels synthesized in situ under molecular engineering control exhibit excellent adhesion, freeze resistance, as well as stretching and humidity sensing capabilities

Hydrogels generally do not adhere well to different substrates and freeze at sub-zero temperatures, limiting their application. In this study, the strategy of replacing water in hydrogels with deep eutectic solvents (DES) was used to address these challenges. Specifically, choline chloride (ChCl) as hydrogen bond acceptor, acrylic acid (AA) and itaconic acid (IA) as hydrogen bond donors and polymerizable monomers constitute PDES. Afterwards, PDES-gel (PG) was obtained by adding a thermal initiator to polymerize AA and IA in PDES. PG has the following characteristics, because PG is almost water-free, it has remarkable low-temperature tolerance without any phase change at −60 °C∼20 °C. Thanks to the carboxyl groups and chloride ions contained in PG, it can form non-covalent interactions such as hydrogen bonding and ionic interactions with different substrates, so PG can adhere to various substrate surfaces. Furthermore, the breaking elongation of the novelty PG was up to ca. 960 %, tensile strength ca. 1 MPa, outstanding transparency with an average light transmittance of about 95 % in the visible-light range. Ultimately, the novel PG exhibited certain capabilities for moisture detection and deformation sensing. The new PDES-gel material developed using PDES is expected to provide new ideas for the advancement of wearable devices.

Bromine-containing copolymer polycarbonate for simultaneous thermal stability, transparency, and thin-wall flame-retardant polycarbonate

The incorporation of traditional low molecule bromine flame retardants can enhance the flame retardancy of polycarbonate (PC), yet their poor compatibility with PC impairs its transparency and mechanical properties. Here, brominated polycarbonate (B50PC) was synthesized by interfacial polycondensation method using bisphenol A, tetrabromobisphenol A, and triphosgene. The number average molecular weight (Mn) of B50PC reached 14,600, and compared to the low molecule bromine flame retardant tetrabromobisphenol A (TBBPA), its initial decomposition temperature increased by 38.7 % under air atmosphere. The PC composites containing 5 wt% B50PC achieved the V-0 rating in the UL-94 test, with LOI increased by 10.3 %. At the same time, the peak heat release rate (PHRR) was decreased by 28.6 % and the ignition time (TTI) was delayed by 21.3 %. Compared with that of samples with TBBPA, the composite with the same amount of B50PC maintained the original elongation at break of PC and the transmittance remained at 84.9 %. In summary, the composites with B50PC maintains outstanding transparency and mechanical properties while enhancing the flame retardancy. This work has developed a high molecular bromine flame retardant that combines flame retardancy and transparency, offering a strategy for expanding the application of PC in the electronics, construction, and aerospace sectors.

Optimizing transparent electrodes: Interplay of high purity SWCNTs network and a polymer

The discovery of transparent electrodes led to the development of optoelectronic devices such as touchscreens, infrared (IR) sensors, etc. Carbon nanotubes (CNTs) have been a potential replacement for ITO due to their exceptional properties, especially in the IR region. In this work, we present the development of a CNT-polymer composite thin film that exhibits outstanding transparency across visible and IR spectra prepared by layer-by-layer (LbL) technique. This approach ensures uniform integration and crosslinking of CNTs into lightweight matrices, and also represents a cost-effective method for producing transparent electrodes with remarkable properties. The produced films achieved a transparency above 80 % in the UV/VIS range and approximately 70 % in the mid-IR range. The sheet resistance of the fabricated thin films was measured at about 4 kΩ/sq, showing a tendency to decrease with the number of bilayers. In this work we have investigated electrical properties and transport mechanisms in more detail with computational analysis. Computational analysis was performed to better understand the electrical behavior of nanotube-polymer junctions in the interbundle structure. Based on all results, we propose that the transparent electrodes with 4 and 6 bilayers are the most optimal structures in terms of optical and electrical properties.

Fabrication of highly transparent AlON ceramics by inhibiting decomposition of AlON

In consolidation of AlON, the extensive decomposition of AlON into α-Al2O3 and AlN during sintering is one of the major reasons that significantly retard its densification process. To accelerate densification of AlON, an ultra-low concentration of La2O3 (0.03 wt%) and Y2O3 (0.02-0.04 wt%) was co-doped as sintering additives to inhibit decomposition of AlON during sintering for fast fabrication of highly transparent AlON ceramics. The phase transformation, microstructure evolution and densification process of the samples undoped and doped additive during heating were studied to investigate the densification mechanism. The results reveal that, compared to the samples undoped additive and single-doped with La2O3, the α-Al2O3 content of the samples co-doped with La2O3 and Y2O3 is significantly deduced at ≤1600 °C, which indicates that the decomposition of AlON is effectively inhibited by co-doping La2O3 and Y2O3. The reduction of α-Al2O3 along with the deceleration effect of La3+ on mass transfer, contributes to more small particles being conserved at high temperatures. Base on this, at later stage of sintering, benefiting from the enhanced mobility of grain boundary by Y3+, AlON ceramics with high relative density (99.79 %) and excellent transparency were obtained via pressureless sintering at 1880 °C for 2.5 h by co-doping 0.03 wt% La2O3 and 0.04 wt% Y2O3. The maximum transmittance of the fabricated AlON ceramics is up to 81.6 % at 3600 nm, and a transmittance of 76.0 % was measured at 400 nm. The ultra-low doping amount of La2O3 and Y2O3 and the high relative density should be the main reasons that lead to the outstanding transparency of the obtained AlON. Additionally, the fabricated AlON ceramics also exhibit a high Vickers hardness of 18.89 ± 0.18 GPa.

Transparent Self-Healing Anti-Freezing Ionogel for Monolayered Triboelectric Nanogenerator and Electromagnetic Energy-Based Touch Panel.

The advent of Internet of Things and artificial intelligence era necessitates the advancement of self-powered electronics. However, prevalent multifunctional electronics still face great challenges in rigid electrodes, stacked layers, and external power sources to restrict the development in flexible electronics. Here, a transparent, self-healing, anti-freezing (TSA) ionogel composed of fluorine-rich ionic liquid and fluorocarbon elastomer, which is engineered for monolayered triboelectric nanogenerators (M-TENG) and electromagnetic energy-based touch panels is developed. Notably, the TSA-ionogel exhibits remarkable features including outstanding transparency (90%), anti-freezing robustness (253 K), impressive stretchability (600%), and repetitive self-healing capacity. The resultant M-TENG achieves a significant output power density (200mW m-2 ) and sustains operational stability beyond 1 year. Leveraging this remarkable performance, the M-TENG is adeptly harnessed for biomechanical energy harvesting, self-powered control interface, electroluminescent devices, and enabling wireless control over electrical appliances. Furthermore, harnessing Faraday's induction law and exploiting human body's intrinsic antenna properties, the TSA-ionogel seamlessly transforms into an autonomous multifunctional epidermal touch panel. This touch panel offers impeccable input capabilities through word inscription and participation in the Chinese game of Go. Consequently, the TSA-ionogel's innovation holds the potential to reshape the trajectory of next-generation electronics and profoundly revolutionize the paradigm of human-machine interaction.

Optically transparent and high-strength glass-fabric reinforced composite

Fiber reinforced polymer composites (FRPs) are widely utilized in various industrial applications due to their significant advantages such as low cost and superior mechanical properties. However, owing to the trade-off between high mechanical strength and high optical transparency with typical FRPs, it is technically challenging to achieve high mechanical performance while meeting the optical requirements for transparent electronics and automotive applications. We herein report the synthesis of a transparent fiber reinforced polymer (tGFRP) by incorporating reinforced E-glass fiber into refractive-index-tunable thermosetting epoxy resin and the consequential advantageous opto-mechanical properties. By doping organic molecules, the optical property of the epoxy-based resin system has been efficiently engineered, achieving the match of the chromatic dispersions of the E-glass fiber and the epoxy resin. By the means of a novel technique derived from infusion treatment and in-situ polymerization combined with a liquid composite molding (LCM) method, both surface and bulk defects have been efficiently mitigated. With the refractive-index of the epoxy matrix matched with that of the embedded fiber fabrics, high transparency up to 88% has been realized with 10v.% fiber loading (500 μm thick tGFRP). An outstanding transparency and superior mechanical properties were achieved on 2 mm thick samples, maintaining up to 85% transmittance even when using 25 layers of E-glass fabric, corresponding to 50 v.% fiber. This work has shed light on the development of transparent composite materials for applications such as in construction, transportation, and protective equipment.

Developing core-shell silica nanoparticles to create multifunctional coating with excellent antireflection, enhanced antifogging and anticorrosion performances

How to fabricate a multifunctional coating with controllable ultralow refractive index (RI), high antifogging and anticorrosion performances by a facile method is still one of the great challenges. In this work, a simple and time-saving approach involving a microwave-assisted sol-sel process was developed to fabricate a novel core-shell structured silica nanoparticle sol by co-condensation of perfluorodecyltriethoxysilane (F-DTOS) and tetraethoxysilane (TEOS) and self-condensation of F-DTOS. Results suggest that both the co-condensations and self-condensations not only give a layer of low surface energy –C10H4F17 groups on the silica particles but also enlarge the hybrid silica particle size, providing more and larger voids to form the high porosity. After spinning the silica nanoparticles on the substrate, the obtained optical coating exhibits the controllable ultralow refractive index (RI) and outstanding transparency. The minimum RI and maximum transmittance of our developed coating is up to ~1.04 and ~100 %, respectively. Moreover, because of the high porosity and the presence of low surface energy –C10H4F17 groups in the coating, the coating has the high hydrophobicity (water contact angle ~108.8°), which not only makes it excellent antifogging performance but also affords it high-efficient anticorrosion property. After immersion in a 3.5 wt% NaCl solution for 7 days, the Rct value of the coating could be higher than 7.3 × 104 Ω cm2. It is believed that our developed method used to fabricate such multifunctional coating does not need any costly equipments, complex steps and time-consuming, making it well suited for industrial application.

Advancing high-performance tailored dual-crosslinking network organo-hydrogel flexible device for wireless wearable sensing

Conductive hydrogels are essential for enabling long-term and reliable signal sensing in wearable electronics due to their tunable flexibility, stimulus responsiveness, and multimodal sensing integration. However, developing durable and dependable integrated hydrogel-based flexible devices has been challenging due to mismatched mechanical properties, limited water retention capability, and reduced flexibility. This work addresses these challenges by employing a tailored physical–chemical dual-crosslinking strategy to fabricate dynamically reversible organo-hydrogels with high performance. The resultant organo-hydrogels exhibit exceptional characteristics, including high stretchability (up to ∼495% strain), remarkable toughness (with tensile and compressive strengths of ∼1350 kPa and ∼9370 kPa, respectively), and outstanding transparency (∼90.3%). Moreover, they demonstrate excellent long-term water retention ability (>2424 h, >97%). Notably, the organo-hydrogel based sensor exhibits heightened sensitivity for monitoring physiological signals and motions. Furthermore, our integrated wireless wearable sensing system efficiently captures and transmits various human physiological signals and motion information in real-time. This research advances the development of customized devices utilizing functional organo-hydrogel materials, making contributions to fulfilling the increasing demand for high-performance wireless wearable sensing.

Design of P-decorated POSS towards flame-retardant, mechanically-strong, tough and transparent epoxy resins

Epoxy resins (EPs) are known for their durability, strength, and adhesive properties, which make them a versatile and popular material for use in a variety of applications, including chemical anticorrosion, small electronic devices, etc. However, EP is highly flammable due to its chemical nature. In this study, phosphorus-containing organic–inorganic hybrid flame retardant (APOP) was synthesized by introducing 9, 10-dihydro-9-oxa-10‑phosphaphenathrene (DOPO) into cage-like octaminopropyl silsesquioxane (OA-POSS) via Schiff base reaction. The improved flame retardancy of EP was achieved by combining the physical barrier of inorganic Si-O-Si with the flame-retardant capability of phosphaphenanthrene. EP composites containing 3 wt% APOP passed the V-1 rating with a value of LOI of 30.1% and showed an apparent reduction in smoke release. Additionally, the combination of the inorganic structure and the flexible aliphatic segment in the hybrid flame retardant provides EP with molecular reinforcement, while the abundance of amino groups facilitates a good interface compatibility and outstanding transparency. Accordingly, EP containing 3 wt% APOP increased in tensile strength, impact strength, and flexural strength by 66.0 %, 78.6 %, and 32.3 %, respectively. The EP/APOP composites had a bending angle lower than 90°, and their successful transition to a tough material highlights the potential of this innovative combination of the inorganic structure and the flexible aliphatic segment. In addition, the relevant flame-retardant mechanism revealed that the APOP promoted the formation of a hybrid char layer containing P/N/Si for EP and produced phosphorus-containing fragments during combustion, showing flame-retardant effects in both condensed and vapor phases. This research offers innovative solutions for reconciling flame retardancy & mechanical performances and strength & toughness for polymers.

The Fabrication of High-Hardness and Transparent PMMA-Based Composites by an Interface Engineering Strategy.

The high-hardness and transparent PMMA-based composites play a significant role in modern optical devices. However, a well-known paradox is that conventional PMMA-based composites with high loadings of nanoparticles usually possess high surface hardness at the cost of poor transparency and toughness due to the aggregation of nanoparticles. In this work, ideal optical materials (SiO2/PMMA composites) with high transparency and high surface hardness are successfully fabricated through the introduction of the flow modifier Si-DPF by conventional melt blending. Si-DPF with low surface energy and high transparency, which is located at the SiO2/PMMA interface, and nano-SiO2 particles are homogeneously dispersed in the PMMA matrix. As an example, the sample SiO2/PMMA/Si-DPF (30/65/5) shows outstanding transparency (>87.2% transmittance), high surface hardness (462.2 MPa), and notched impact strength (1.18 kJ/m2). Moreover, SiO2/PMMA/Si-DPF (30/65/5) also presents a low torque value of composite melt (21.7 N⋅m). This work paves a new possibility for the industrial preparation of polymer-based composites with excellent transparency, surface hardness, processability, and toughness.

Highly Transparent Polycrystalline MgO via Spark Plasma Sintering.

Optically transparent ceramics and MgO in particular are promising materials for a wide range of optical applications. This study introduces exceptionally highly transparent MgO ceramics produced via spark plasma sintering (SPS) at relatively low temperature and pressure by optimal incorporation of LiF as a sintering additive. The effect of LiF content on the microstructural and optical properties is presented with emphasis on its function as a densification aid and an agent for minimizing residual carbon contamination. Fully dense MgO discs, 20 mm in diameter and 2 mm thick, with ∼80% in-line transmission at 800 nm and >85% transmission in the infrared range (2-6 μm), are attained. These results demonstrate outstanding transparency in SPS polycrystalline MgO in the 800 nm range, only 7% below the theoretical value. In addition, this work strengthens our understanding of the LiF action mechanism during MgO sintering and its influence on texture development in the SPS-pressing direction. These findings pave the way for fabrication of large, fully dense samples with nearly theoretical transparency.

Transparent and flexible vesicles/lamellae mixed matrix organic-bridged polysilsesquioxane coatings as water vapor barrier

Siloxane-based hybrid materials with lamellar nanostructure have great potential to be water vapor barrier layer for electronic devices and photovoltaic cells encapsulation. Improving water vapor barrier ability was still a big challenge. This research article proposed a facile one-pot methodology to prepare vesicles/lamellae mixed matrix organic-bridged polysilsesquioxane (BPSQ) composite coatings with excellent water vapor barrier performance. The composite coatings were fabricated from three thioether-ester-briged silsesquioxane by sol-gel method in the presence of phytic acid. Phytic acid not only acted as catalyst to catalyze the hydrolysis and condensation reactions of silsesquioxane precursors, but also formed vesicles in ethanol solution. Experimental evidence demonstrated that vesicles size mainly influenced the barrier property of composite coatings, and with bigger vesicles, the composite coating showed 10-fold enhancement in water vapor barrier ability compared to the corresponding BPSQ coating with only lamellar nanostructure. Moreover, the vesicles/lamellae composite coatings displayed outstanding transparency and flexibility which would meet the requirements of optical related moisture resistant application fields.

Biobased-interlayer glass composite with improved mechanical properties and ultraviolet radiation shielding

This paper reports a biobased-interlayer glass composite that augments the flexural strength and stiffness of glass and Ultraviolet protection. The benign interlayer consists of polyvinyl alcohol, lignin, and citric acid as a crosslinker. The interlayer was doctor bladed on soda-lime glass, encrusted by a second glass, dried, then heat-treated to warrant its strength and durability. Three-point bending tests disclosed an improvement in flexural strength (53.1%), flexural strain (43.1%), and flexural stiffness (9.4%) in contrast to the pristine glass. Furthermore, the laminated glass effectively shields broadband Ultraviolet radiation and concurrently displays outstanding transparency over 75% in the visible range. This research offers an innovative design approach for robust Ultraviolet shielding and strengthening of glass in a facile and cost-effective manner. Future applications of this novel composite include greenhouse cover, automobile windshields, security, and museum artwork.

Regulation of orientation birefringence for cellulose acetate film: The role of crystallization and orientation

Cellulose acetate (CA) based films are widely used in liquid crystal displays due to their outstanding transparency, and a certain orientation birefringence of CA films is required when they are used as retardation films. The regulation of orientation birefringence is usually from the perspective of stretch-induced orientation, while the effects of crystallization behaviors of CA films remain obscure. In this study, the roles of crystallization and orientation on the orientation birefringence of CA films were elucidated. For cellulose diacetate films, the orientation birefringence is dominated by the orientation degree. In comparison, apart from the orientation degree, crystallinity is another key variable to regulate the orientation birefringence of cellulose triacetate and plasticized cellulose triacetate films, originating from the birefringence heterogeneity of the crystalline and amorphous phases. These results provide valuable guidelines for the production of CA-based optical films with excellent optical performance.

An Ultra‐Strong, Water Stable and Antimicrobial Chitosan Film with Interdigitated Bouligand Structure

AbstractNatural polymeric materials are an attractive potential replacement for non‐biodegradable plastics. However, one of the main challenges for high‐end applications of these materials, is to maintain their high mechanical properties in a watery environment. Here, inspired by the reinforcement principle of multiscale architecture in natural crab exoskeletons, an ultra‐strong and hydrostable film is developed through a top‐down method directly from the crab shell. The resulting chitosan film exhibits an outstanding isotropic tensile strength of ≈220 MPa and a superior wet strength of ≈70 MPa, which is significantly higher than that of conventional polysaccharide‐based materials and many commercially used plastics. Its excellent mechanical properties are due to the realization of strong interactions between chitosan fibrils even in wet conditions through interdigitation and densification processes without other additives. Additionally, it also possesses outstanding transparency, flexibility, antimicrobial ability, and biodegradability, making it a promising high‐performance and eco‐friendly material for many potential applications.

Flexible Normally Transparent Smart Window Modulating Near‐Infrared Penetration under Ambient Conditions

AbstractSmart windows that both reversibly occlude visible light and modulate the penetration of near‐infrared (NIR) light save a great deal of energy. Here, a simple, super‐fast, electrically switchable smart window that initially reflects NIR light and then scatters it in response to thermal stimuli is designed and fabricated. Transparent polymer‐stabilized cholesteric liquid crystals (PSCLCs) are prepared by photo‐polymerizing RM 257 monomers in which the planar CLCs fully reflected NIR light (1050–1550 nm). Next, an ultra‐thin, thermotropic, W0.003V0.997O2‐doped polyvinylpyrrolidone hybrid thin layer that modulates NIR light penetration over a very broad temperature range is overlaid on the PSCLCs, and the final WVO‐PSCLCs smart window features four NIR modulation modes. Specifically, when a model wood house with three 1.5‐ × 2‐cm WVO‐PSCLCs smart windows is thermally irradiated by a 250‐W infrared light for 10 min, the internal temperature is 4.8 °C less than that of a house lacking smart windows. Flexible smart windows fabricated from polyethylene terephthalate (PET) could be bent through a radius of 15 mm without any noticeable damage, and are very resistant to external vertical pressure. The flexible WVO‐PSCLCs smart windows are versatile, and afford outstanding transparency management and modulation of NIR light penetration.

Nanofiber-reinforced transparent, tough, and self-healing substrate for an electronic skin with damage detection and program-controlled autonomic repair

The self-healing ability introduced into the flexible electronics is of significance to realize the skin-like recovery of their original functions from unexpected damage, vastly boosting the development of sustainable electronics. However, simultaneously achieving excellent mechanical strength and reliable healing efficiency is confronted with extreme challenge. Herein, a nanofiber-reinforced self-healing substrate, primely mimicking the structure and functions of the human skin, is developed for an intelligent electronic skin (e-skin) with a controlled feedback system. The nanofiber-reinforced skin-like substrate exhibits tremendously enhanced mechanical properties, tensile strength and toughness considerably increasing by 836% and 1000% compared to those of pure matrix, as well as greatly reserving healing efficiency. This substrate also shows high transmittance of ~95%, satisfying the requirement of outstanding transparency in e-skin. Meanwhile, a multilayer-structure e-skin is developed based on the nanofiber-reinforced skin-like substrate, in which the program can detect damage and automatically accelerate healing through Joule heat. Owing to the programmed repairing capability, our transparent and robust e-skin shows promising potential as a superior alternative for artificial skin in the field of robotics.

Stretchable and transparent multimodal electronic-skin sensors in detecting strain, temperature, and humidity

Smart electronic skins (e-skins) have garnered extensive attentions owing to their potentials in health monitoring, human-machine interactions, and soft robotics. Herein, stretchable and transparent multimodal e-skin sensors composed of poly(vinyl alcohol) (PVA), citric acid (CA) and Ag nanoparticles (AgNPs) are developed by a simple in-situ reduction and solvent casting technology, which possess multiple sensing capabilities in strain, temperature and humidity. Although utilizing the nontransparent AgNPs as sensing components, the as-prepared PVA/CA/AgNPs sensor exhibits not only ultrahigh stretchability (up to 596% strain) but also outstanding transparency (the transmittance > 89%) attributed to the homogeneous dispersion of CA and AgNPs in PVA matrix. As flexible strain sensor, this sensor exhibits wide strain sensing range (1–200%), rapid response (90 ms), and excellent linearity of outputted signals (correlation coefficient: 0.998). Moreover, high-precision thermo-sensation (0.1 ℃) and outstanding temperature sensitivity (−0.076/℃ in the range of 30–40 ℃) make the sensor can detect subtle temperature variation. Furthermore, the good hygroscopicity of PVA and CA endows the fabricated sensor with outstanding humidity sensing performance, which can give human skin moisture information in real-time. More importantly, the designed sensor possesses excellent recyclability and can be reused for many times via the simple dissolution-reshaping treatment, which could reduce the electronical waste.

Establishment of a Knowledge‐and‐Data‐Driven Artificial Intelligence System with Robustness and Interpretability in Laboratory Medicine

Laboratory medicine plays an important role in clinical diagnosis. However, no laboratory‐based artificial intelligence (AI) diagnostic system has been applied in current clinical practice due to the lack of robustness and interpretability. Although many attempts have been made, it is still difficult for doctors to adopt the existing machine learning (ML) patterns in interpreting laboratory (lab) big data. Here, a knowledge‐and‐data‐driven laboratory diagnostic system is developed, termed AI‐based Lab tEst tO diagNosis (AI LEON), by integrating an innovative knowledge graph analysis framework and “mixed XGboost and Genetic Algorithm (MiXG)” technique to simulate the doctor's laboratory‐based diagnosis. To establish AI LEON, we included 89 116 949 laboratory data and 10 423 581 diagnosis data points from 730 113 participants. Among them, 686 626 participants were recruited for training and validating purposes with the remaining for testing purposes. AI LEON automatically identified and analyzed 2071 lab indexes, resulting in multiple disease recommendations that involved 441 common diseases in ten organ systems. AI LEON exhibited outstanding transparency and interpretability in three universal clinical application scenarios and outperformed human physicians in interpreting lab reports. AI LEON is an advanced intelligent system that enables a comprehensive interpretation of lab big data, which substantially improves the clinical diagnosis.