In line with the fourth industrial revolution, most countries have imposed a variety of regulations or policies for the goals of energy conservation, sustainable development, and industrial transition. Renewable energy production and its production process, which is widely discussed, especially in the context of sustainable energy, has become more important with Industry 4.0. This paper tested the relation among economic growth, renewable electricity generations (% of GDP), Industry 4.0, industrial structure, trade openness, financial development, and research and development expenditure for G20 countries in 2000–2021 by employing a panel quantile regression approach and various panel cointegration tests in addition to investigation of panel Granger causality among the analyzed variables. The variables of industrial structure, trade openness, and financial development were selected as control variables. Since this study is the first study on this topic, it will contribute to the development of the literature by providing resources for future studies about I4.0, renewable energy production, and economic growth. Furthermore, this study will not only contribute to the literature by revealing the theoretical and empirical relationship between these variables but will also shed light on the policies that G20 countries will produce in this regard. According to results, all variables examined have significant causal effects: unidirectional causality from economic growth to Industry 4.0, to research and development, and to renewable energy output and, also, from research and development to renewable energy output. Bidirectional causality and feedback effects between renewable energy and Industry 4.0 are determined. Further, unidirectional causality from industrial structure, from openness to trade, and from financial development to renewable energy output are determined. Results indicate renewable-enhancing effects of Industry 4.0.