Dialysis is a treatmentthat filters and purifies the blood using a machine. This helps keep your fluids and electrolytes in balance when the kidneys can’t do their job. The clinical pharmacy activities in End Stage Renal Disease and Out Patient Dialysis in Jayabharath hospital Nellore. To evaluate the clinical pharmacy activities in end stage renal disease and outpatient dialysis in a tertiary care hospital. Totally 70-100 patients with ESRD and dialysis in the age group of 30 to 60 enrolled in the study and 70 patients with ESRD where included in the study. Evaluation included thecollection of laboratory data, efficacy assessment of decrease in GFR, persistent proteinuria and kidney failure in ESRD and dialysis and due to clinical pharmacy activities increase life span of patients. Totally 30 subjects had low GFR and 28 subjects had proteinuria. Clinical pharmacy activities significantly reduced the incidence low GFR and Proteinuria to 5 and 7 respectively Clinical pharmacy play a significant role in relieving the symptoms of End Stage Renal Disease (ESRD) and Dialysis. Recent researches and the outcomes of this study have suggested that a more comprehensive investigation must be performed to determine the role of clinical pharmacy activities in ESRD and Dialysis. Clinical pharmacy significantly reduced symptoms of ESRD and Dialysis. Clinical pharmacy significantly reduced symptoms of ESRD and Dialysis. And also, it willbe helpful to patient regarding disease and treatment. It also significantly increased the livebirth rates. Key words: ESRD, Dialysis, GFR, Proteinuria, Kidney failure