Relevance. Effective pain relief is required for high-quality outpatient dental treatment in children. Рeriodontal local anesthetic methods are easier to implement and safer for young patients. Purpose. To conduct a comparative analysis of the use of various local anesthetics when using a modified periodontal method in the treatment of caries and pulpitis of permanent teeth in children 7–12 years old at an outpatient dental appointment. Materials and methods. The study involved 108 children of the 7–12 years old age group, who need treatment for caries and pulpitis of permanent molars. Local anesthetic was administrated 4% solution of articaine without a vasoconstrictor, with epinephrine at concentrations of 1:200,000, 1:400,000, 2% solution of articaine without a vasoconstrictor and with epinephrine 1:200,000. To determine the effectiveness of the treatment a developed analog-visual scale was used. Results. The high efficiency and safety of the use of modified periodontal anesthesia using 2 and 4% solutions of articaine with epinephrine in the treatment of permanent molars in children aged 7–12 years was determined.