Aims: This study was to evaluate the risk factors associated with tooth wear lesions in patients attending a dental clinic. Context: Tooth wear lesions entail the loss of dental hard tissues in the absence of caries or trauma. They include abrasion, attrition, and erosion. The etiology is often related to habits leading to insidious symptoms with similar presentations in both community and hospital patients. Materials and Methods: This cross-sectional study involved patients attending the outpatient dental clinic of a Nigerian Teaching Hospital over a 3-month period. A semi-structured questionnaire was used to elicit information from the respondents. Results: A total of 152 respondents aged 17–80 years and above, comprising 86 males (56.6%), and 66 females (43.3%) constituted the study population. The Binis were the most represented 34.2%, followed by the Esans 21.1%, while the least represented were the Yorubas (6.6%). The occupations represented in this study include civil servants (30.3%), unskilled workers (23.7%), and non-medical professionals (7.9%). Tooth wear lesions were present in 55.3% of the respondents. Attrition accounted for 29.6%, Abrasion (11.8%), combination of attrition and abrasion (4.6%), and abfraction (2.0%). There was a statistically significant association between tooth wear lesions and age, occupation, sensitivity or pain, tooth cleaning aids, toothbrush texture brushing technique, intake of carbonated beverages, and method of intake. Conclusion: Tooth wear lesions such as attrition and abrasion were prevalent among the respondents in this hospital setting and, therefore, represent an important group of dental problems among this population. It is, therefore, important to direct the appropriate oral health awareness program for the prevention, early detection, and management of these conditions.