Background: One of the most chronic diseases can effect on quality of life for children and their families are chronic kidney diseases. It can cause direct adverse impact on children life. So, empowerment of family and children is essential to enhance and improve their quality of life. For this reason, the aim of this study was to evaluate the effect of the family empowerment model on the quality of life for children with chronic kidney diseases. It was hypothesized that children with chronic kidney diseases who received family empowerment model sessions will have better quality of life than children who did not. The design of this study was quasi experimental design. It was conducted in Menoufia University Hospital and Teaching Hospital in Shebin El-Kom in Menoufia governorate. For data collection, a purposive sample of 60 children with chronic kidney diseases and their parents was obtained from the previous mentioned settings. Tools of this study were Social characteristics sheet and the questionnaire of Core Ped QoL, version 4. The results of this study showed that significant improvement in quality of life after implementation of family empowerment model for children with chronic kidney diseases and their parents. It was concluded that that family empowerment model was effective in improved the quality of life for children with chronic kidney diseases. Therefore, this study recommended that this model to be used in inpatient and outpatient children's health care.