Cellular MicrobiologyVolume 23, Issue 1 e13286 CORRIGENDUMFree Access Corrigendum This article corrects the following: Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival Jennifer A. Caine, Yi-Pin Lin, Julie R. Kessler, Hiromi Sato, John M. Leong, Jenifer Coburn, Volume 19Issue 12Cellular Microbiology First Published online: September 26, 2017 First published: 09 November 2020 https://doi.org/10.1111/cmi.13286AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat In “Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival”, by Caine et al. (2017)which was published in volume 19, issue 12, September 2017, the authors wish to notify readers that we have not been able to reliably reproduce the data in Figure 5. The corresponding text “To determine if OspC is able to directly inhibit the complement cascade allowing WT B. burgdorferi to survive in the bloodstream of mice, we performed an ELISA-based complement activation assay. Plates were coated with initiators of each pathway of the complement cascade; Immunoglobulin M (IgM; classical pathway), mannan (lectin pathway), lipopolysaccharide (LPS; alternative pathway), or buffer (negative control). Coated plates were incubated with a mixture of pooled active human serum and various concentrations of purified GST-OspC B31, GST, or buffer, and complement deposition was measured in each well by ELISA (Figure 5). Wells coated with IgM or mannan and incubated with 1000 nM GST- OspC have significantly lower levels of deposited complement compared to wells incubated in GST (Figure 5a,b). This effect is not seen in LPS coated wells, where the addition of GST-OspC does not inhibit complement deposition compared to GST at any concentration tested (Figure 5c) and Figure 5” should be removed from the paper. In addition, Experimental Procedures section 4.13 “Complement Inhibition ELISAs” should be removed. All other data shown are reproducible, so our primary conclusion is supported. REFERENCE Caine, JA, Lin, Y-P, Kessler, JR, Sato, H, Leong, JM, and Coburn, J. Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. Cellular Microbiology, 2017; 19:e12786. PMID 28873507, PMCID PMC5680108. https://doi.org/10.1111/cmi.12786 Volume23, Issue1January 2021e13286 ReferencesRelatedInformation