In this paper we review current ideas about the composition, horizontal and vertical distribution, and microphysical properties of clouds and aerosols in Jupiter's upper troposphere and stratosphere. We also discuss several key photochemical species, their relation to aerosol formation, and their implications for transport processes. We treat photochemistry in the context of comparative planetology and point out important similarities and differences among the outer planet atmospheres. Our approach emphasizes observational data of relevance to cloud properties, and to this end we assemble a wide assortment of ground-based and spacecraft observations. We challenge some widely held views about the distribution of clouds in the troposphere and present a rationale for alternative interpretations.