Selecting an appropriate ANN model is crucial for speeding up the process of building performance simulation during the design phase of residential building layouts, particularly when evaluating three or more green performance metrics simultaneously. In this study, daylight, visual, and outdoor thermal metrics were selected as main green performance. To find the suitable ANN model, sensitivity analysis was used to obtain a set of proper parameters applied to the ANN structure. To train the ANN model with a higher predicting accuracy, this paper tested four different scenarios of ANN parameter setups to find some general guidelines about how to set up an ANN model to predict DF, sunlight hours, QuVue and UTCI. The results showed that an ANN model with a combined output variable demonstrated better average prediction accuracy than ANN models with a separated output variable. Having two times the number of training samplings compared to the number of input variables can lead to a high accuracy of prediction. The ideal number of neurons in the hidden layer was approximately 1.5 times the number of input variables. These findings of how to improve the ANN model may provide guidance for modeling an ANN for building performance.