Outcome Of Dengue Fever Research Articles

A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India.

Background and Aims:The incidence of specific complications and adverse outcomes in dengue patients needing admission to intensive care units (ICU) may be quite variable in different regions of India presumably because of different strains of dengue virus or due to re infection.Methods:Patients admitted with acute febrile illness (AFI) with either positive IgM antibody or NS1 antigen for dengue were enrolled. Data were collected for 3 years (2015-2017). A total of 313 patients with acute febrile illness were admitted in the study period (2252 total ICU admissions). A total of 137 (43.76%) cases were serologically proven as dengue fever.Results: Median age (IQR) of study population was 36.0 (26.0–52.0) years. Liver (65.7%) was the main organ involved followed by acute kidney Injury (AKI) (18.6%). Dengue Shock Syndrome (DSS) was found in 18.6% of cases. Fifty-two patients died and the crude mortality was 38.0%. On multivariate analysis APACHE Score <10, thrombocytopenia, hepatic dysfunction, AKI and dengue shock syndrome (DSS) were associated with the risk of mortality.Conclusion: This study in ICU patients showed high mortality in relatively younger patients. Liver (in the form of raised Bilirubin) was the most common organ dysfunction. The need to recognise early warning signs for ICU admission is highlighted.

Clinical profile of dengue fever patients in tertiary care hospital of North India

Introduction: In India, Dengue epidemics are becoming more frequent. The majority of dengue virus infection are self limiting, but complications may cause substantial morbidity and mortality. Methods: In this retrospective study, medical records were reviewed and analyzed. Patients were classified into dengue with and without warning sign and severe dengue (DHF/DSS). Objectives: To assess clinical profile of dengue infection in children less than 18 years of age and to evaluate outcome of dengue fever admitted from June to December 2018, in Department of Pediatrics, Sarojini Naidu Medical College, Agra. Results: A total of 50 dengue positive patients were classified into dengue with or without warning signs 42(84%) and 8 (16%) severe dengue cases. The most commonly involved children were male between 5-10 yr (36%) of age group followed by 1-5 yr (34%). Most common clinical manifestation was fever observed in 96% cases followed by rash (66%), pain abdomen (52%) and vomiting in 26% cases.46% cases of dengue had warning signs. Most common clinical and radiological findings were ascites seen in 24% cases followed by pleural effusion. Elevation of Aspartate Transaminase (SGOT) in 82% and thrombocytopenia was seen in 60% cases. Conclusion: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were varying clinical presentation. Early clinical suspicion and diagnosis with prompt management accompanied by preventive measures can prevent morbidity and the mortality associated with dengue.

Clinical Profile and Outcome of Dengue Fever in Multidisciplinary Intensive Care Unit of a Tertiary Level Hospital in India.

ABSTRACTBackgroundIndia is one of the seven identified countries in South-East Asia region regularly reporting dengue fever (DF)/dengue hemorrhagic fever (DHF) outbreaks. Even though the dengue prodrome and evolution of illness are most often similar in many patients, progress and outcome may differ significantly depending on the severity of illness as well as treatment instituted. We studied the clinical manifestations, outcome and factors predicting mortality of serology confirmed dengue fever cases admitted in Multidisciplinary Intensive Care Unit (MICU) of a high acuity healthcare facility in India.MethodologyAll patients with serology proven dengue fever admitted to MICU between 1st July 2015 and1st December 2015 were included in the study. Clinical presentation, laboratory findings, severity of illness scores and outcome were recorded.ResultsMajority of the patients (58.4%) belonged to 21–40 year age group. Hepatic (96.8%) followed by hematological (79.2%) involvement were the most common findings. CNS involvement observed among 27%. Survival to hospital discharge was 78.9%. Respiratory and gastrointestinal system involvement was associated with increased mortality. Acute respiratory distress syndrome (ARDS), acute kidney injury (AKI) and shock were the clinical syndromes associated with mortality. Serum lactate, aspartate transaminase (AST) and alanine transaminase (ALT) were significantly elevated among non survivors. Significant difference in sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) scores was also observed among survivors and non survivors.ConclusionOrgan system involvement and higher disease severity scores are strong predictors of mortality. High index of suspicion for atypical manifestations of dengue is warranted.How to cite this articlePadyana M, Karanth S, Vaidya S, Gopaldas JA. Clinical Profile and Outcome of Dengue Fever in Multidisciplinary Intensive Care Unit of a Tertiary Level Hospital in India. Indian J Crit Care Med 2019;23(6):270–273.

Clinical profile, predictors of DHF and outcome of dengue fever in children at government tertiary care centre

Clinical profile, predictors of DHF and outcome of dengue fever in children at government tertiary care centre

Clinical Study of Diagnosed Cases of Dengue Fever in Tertiary Care Hospital in North Maharashtra

Aims and Objective: To study the clinical presentations, laboratory profile, hematological complications and outcome of dengue fever. Materials and Methods: Descriptive study was carried which includes adult males and females who were serologically confirmed cases of dengue. These patients were assessed for their demographic features (age/sex etc.); clinical profile various signs and symptoms; labotrary profile; complications and outcome as mentioned in the proforma. Results: Total 56 patients studied. Out of 56 cases, the maximum number of cases, 22 (39.2%), belonged to the age group between 20 to 40 years. Thus the mean age of hospitalized patients was 31.2 ± 4.5 yrs. There were 33 (58.9%) males and 23 (41.1%) female patients. Majority were Dengue Hemorrhagic fever 20 (35.7%) and 8 (14.2%) were cases of severe dengue according to WHO guidelines. Fever was present in all patients. Two patients developed DIC and died. Conclusion: Patients with dengue syndrome showed varied clinical presentation. Symptoms and clinical signs are non specific. Most adults were positive for symptoms like fever, myalgia, arthralgia, and skin rash and bleeding.

A study of clinical manifestations, laboratory profile and outcome of dengue fever in a tertiary care centre in South Karnataka

A study of clinical manifestations, laboratory profile and outcome of dengue fever in a tertiary care centre in South Karnataka

Clinical Study of Diagnosed Cases of Dengue Fever in Tertiary Care Hospital in North Maharashtra

Aims and Objective: To study the clinical presentations, laboratory profile, hematological complications and outcome of dengue fever. Materials and Methods: Descriptive study was carried which includes adult males and females who were serologically confirmed cases of dengue. These patients were assessed for their demographic features (age/sex etc.); clinical profile various signs and symptoms; labotrary profile; complications and outcome as mentioned in the proforma. Results: Total 56 patients studied. Out of 56 cases, the maximum number of cases, 22 (39.2%), belonged to the age group between 20 to 40 years. Thus the mean age of hospitalized patients was 31.2 ± 4.5 yrs. There were 33 (58.9%) males and 23 (41.1%) female patients. Majority were Dengue Hemorrhagic fever 20 (35.7%) and 8 (14.2%) were cases of severe dengue according to WHO guidelines. Fever was present in all patients. Two patients developed DIC and died. Conclusion: Patients with dengue syndrome showed varied clinical presentation. Symptoms and clinical signs are non specific. Most adults were positive for symptoms like fever, myalgia, arthralgia, and skin rash and bleeding.

Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

Background: A study of different presentation and outcome of dengue fever in tertiary care centre.Methods: the observational cross sectional study was carried out from June to October 2016 in Bowring and Lady Curzon hospital attached to Bangalore Medical College and Research Institute. Included patients from 1 to 18 years of age who presented with febrile illness. WHO classification and definitions were used to classify disease as dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Clinically, haematological and biochemical findings were recorded till discharge.Results: during study period,142 patients presented with typical features of dengue fever, male being 86 (60%) and female being 56 (40%). Among 142 cases 64 cases were probable dengue, 50 cases were dengue with warning signs and 28 cases were had severe dengue. Fever (100%) was the most common clinical presentation followed by vomiting (70%), body ache (43%), abdominal pain (23%), headache (12%) and rashes (5%). Laboratory findings included thrombocytopenia, leucopenia and elevated liver enzymes. 126 (88%) cases were discharged in clinical stable conditions, (8%) were died during course of treatment and 8 cases left against medical advice.Conclusions: fever with vomiting and thrombocytopenia were most common presentation of dengue fever, appropriate clinical diagnosis and management is relatively simple, inexpensive and very effective in saving lives as long as long correct and timely interventions instituted.

Clinical, laboratory profile and outcome of dengue fever at a south Indian tertiary care hospital

Clinical, laboratory profile and outcome of dengue fever at a south Indian tertiary care hospital

Clinical and laboratory profile of dengue fever in children during an outbreak - one year study at tertiary care hospital, Chennai, Tamilnadu, India

Background: Dengue fever is a mosquito borne arboviral disease which is of global concern. It is endemic in tropical countries with annual incidence of 7.5 to 32.5 million cases. It commonly affects the young adults and paediatric cases of Dengue haemorrhagic fever has high mortality. The objective of this study was to assess the clinical and laboratory profile and outcomes of dengue fever in children of less than 18 years of age. The study was conducted for a period of one year during an outbreak, in a tertiary care hospital of Chennai, Tamilnadu, India.Methods: This was a prospective cross sectional study and 200 cases of dengue fever were enrolled and classified as per WHO guidelines. The clinical profile and demographic profile was recorded in a structured questionnaire form. Haematological parameters were recorded and followed till the day of discharge. The duration of stay was recorded and outcomes were noted.Results: A total of 200 cases with 113 males and 87 females, 177 non severe dengue cases and 23 severe cases of dengue fever were classified. The mean age of admission was 9 years and mean duration of stay in hospital was 4.61 days. Fever was most common presenting symptom (100%) and hepatomegaly (58.5%) was common clinical finding. Bleeding manifestations were seen in severe dengue cases. Statistical significance was seen in rise in SGOT levels, rise in haematocrit and pleural effusion with severe dengue cases and non-severe dengue cases. The case fatality rate was zero.Conclusions: Understanding the knowledge of presentations and associated features would help to predict the severity of the disease. In children, if symptoms like fever, pain, rashes, and vomiting are associated with Hepatomegaly and elevated SGOT in context of low total platelet count, a strong possibility of dengue fever is present, especially in an epidemic setting. Early suspicion and effective management can reduce the severity.

A prospective seroepidemiologic study on dengue in children in Southeastern Rajasthan, India

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. Objectives: To assess the clinical profile of the dengue infection in children less than 18 years of age and to evaluate the outcomes of dengue fever from July2015 to June 2016 at Pediatric Department of J.K. Lon Hospital, Government Medical College, Kota the largest tertiary care hospital of southeastern Rajasthan. Results: A total of 107 cases were classified into 81 (75.70%) nonsevere and 26(24.30%) severe dengue cases. The most common age of presentation was above 11 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 100% cases and hepatomegaly (22.06%) was the most common physical finding. Elevation in aspartate transaminase (SGOT) was found in 28.03% and thrombocytopenia in 52.30%. The correlation between hepatomegaly and elevated SGOT was significant (value 0.0346). Case fatality rate (CFR) was 0 %. The mean duration of hospitalization was 5.2 days. Conclusion: In children, if symptoms like fever, pain, rashes, and vomiting are associated with hepatomegaly and elevated SGOT in context of low platelet count, a strong possibility of dengue fever is present, especially in an epidemic setting. Early suspicion and effective management can reduce the severity.

Clinical profile and outcome of dengue fever in hospitalized children of South Rajasthan, India

Background: Dengue fever is rising globally and also in India. Dengue can present with varied clinical manifestations. The mortality rate can be reduced by timely diagnosis, strict monitoring and proper fluid resuscitation. Methods: In this study children with positive dengue rapid test in the age group of 0-15 years were included. All cases were classified as WHO new case classification guideline and detailed clinical profile were recorded in proforma. Results: Out of 65 cases, males were 53% and females were 47% with maximum number of cases seen in the age group of 5-10 years (46%). We reported children with dengue without warning signs (23%), dengue with warning signs (64%), and severe dengue (12%) of cases. Fever was observed in all cases. Myalgia and headache was most common symptom followed by mucosal bleed. Hepatomegaly was observed in 90% of cases. Only one case had central nervous system involvement. Lab parameters include raised hematocrit (84%), thrombocytopenia (80%) and leucopenia (44%). Crystalloids were used in (76%). Colloids were not used. Blood products were required in 5 cases. No mortality was observed in our study. Conclusions: Children in the age group of 5-10 years were most commonly affected. Early diagnosis with rapid test, dengue case classification by revised WHO guideline, strict monitoring, appropriate fluid management and judicious use of blood product have yielded a fruitful outcome.

Clinically Profiling Pediatric Patients with Dengue.

Objective:To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry.Materials and Methods:All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16.0 statistical software. After collecting the data, all the variables were summarized by descriptive statistics.Results:Among the 261 confirmed cases of dengue fever non-severe and severe dengue infection was seen in 60.9% and 39.1%, respectively. The mean age (standard deviation) of the presentation was 6.9 + 3.3 years and male: female ratio was 1.2:1. The most common clinical manifestations were fever (94.6%), conjunctival congestion (89.6%), myalgia (81.9%), coryza (79.7%), headache (75.1%), palmar erythema (62.8%), and retro-orbital pain (51.3%). The common early warning signs at the time of admission were persistent vomiting (75.1%), liver enlargement (59.8%), cold and clammy extremities (45.2%), pain abdomen (31.0%), hypotension (29.5%), restlessness (26.4%), giddiness (23.0%), bleeding (19.9%), and oliguria (18.4%). The common manifestation of severe dengue infection was shock (39.1%), bleeding (19.9%), and multi-organ dysfunction (2.3%). The most common complications were liver dysfunction, acute respiratory distress syndrome, encephalopathy, pleural effusion, ascites, myocarditis, myositis, acute kidney injury, and disseminated intravascular coagulopathy. Platelet count did not always correlate well with the severity of bleeding. There were six deaths (2.3%) and out of them four presented with impaired consciousness (66.6%). The common causes for poor outcome were multiorgan failure, encephalopathy, and fluid refractory shock.Conclusion:There has been a resurgence of dengue fever with a change in the pattern of presentation during the recent epidemics. Clinical vigilance and awareness regarding the changing epidemic pattern and timely detection of cases are vital to reduce mortality and morbidity due to severe dengue infection.

Clinical profile and outcome of dengue fever and dengue haemorrhagic fever in pediatric age group

Background: Dengue infection, an arthropod-borne viral hemorrhagic fever, continues to be a major challenge to public health, especially in South-East Asia. We have done an observational study of dengue and dengue hemorrhagic fever in which we have studied the clinical pattern of dengue presentation. Methods: This study was conducted in the CICU and PICU of SCB medical college, Cuttack, Odisha, India. 100 patients, serologically dengue positive were included in this study. Hematological and other clinical parameters were evaluated. Statistical analysis was done after estimating p-value. Results: Fever, vomiting, abdominal pain, hepatomegaly, bleeding diathesis and hypotension were common clinical symptoms. Serological tests, hematocrit, platelet counts, liver enzymes and abdominal ultrasonography and fluid therapy were useful in management of all cases. Conclusions: Patients presented with variable symptoms both in dengue fever and dengue hemorrhagic fever in pediatric age group.

Trends in the clinical and hematological profile of patients with dengue fever

Background: World Health Organization (WHO) estimates that 50-100 million dengue infections occur every year with 22000 deaths. The increasing magnitude of the problem together with its changing epidemiology is an important public health concern. The aim of the present study was to evaluate clinical profile, hematological profile, biochemical profile and outcome of dengue fever and to determine the relationship between clinical profile and hematological profile. Methods: This is a retrospective, observational, hospital-based study. 369 patients, aged more than 12 years, admitted between 1st January to 31st December 2015 with dengue fever were studied for clinical profile including documented bleeding manifestations/bleeding tendencies, hematological profile, biochemical profile and outcome. Results: Dengue cases occurred at higher frequency in 12-30 year age (81.30%), in males (M: F ratio- 2.35:1) and in rainy season (87.26% from September to November). Common presentations on clinical, radiological, haematological and biochemical profile were: fever (100%), headache (73.98%), bodyache (71.81%); hepatomegaly (66.93%), pericholecystic oedema (48.23%), distended GB (38.21%); thrombocytopenia (92.68%), leucopenia (58.26%) and raised liver enzymes (79.94%) respectively. Bleeding manifestations were observed in 48.61% cases of which petechiae (74.68%) was the commonest followed by epistaxis (7.59%), gum bleeding (2.16%), melena (2.16%) mainly. Mean duration of fever prior to hospitalization was 5.06±1.70 days. Mean nadir of platelet count was on 6.83±1.47 day from onset of illness (1st symptom-fever) and 1.77±0.89 day of hospitalization.100% patients had good recovery. Conclusions: Maximum prevalence of dengue was in young, in males and in rainy season. Thrombcytopenia, leucopenia, hepatomegaly, raised liver enzymes-aspartate aminotransferase (AST) and alanine aminotransferase (ALT), pericholecystic oedema are prima facie of dengue. Prompt diagnosis and immediate specific treatment with maintenance of platelet count and haemostatic function gives good recovery.

Dengue Fever Associated Liver Failure

Background: Dengue fever is common in Southeast Asia although liver failure is a rare complication with up to 50% mortality rate reported in children. Objective: To evaluate the characteristics and treatment outcome of dengue fever associated liver failure (DFALF) in a case series of 4 paediatric patients. DFALF was defined as INR>2, regardless of the presence or absence of encephalopathy or INR>1.5 not corrected by Vitamin K in the presence of clinical hepatic encephalopathy, during the course of concurrent dengue infection. Material and methods: Patients with DFALF, admitted to a tertiary paediatric centre in Singapore over a 6 year period (January 2009-December 2015) were identified from the Gastroenterology and Infectious Disease databases. Case records were retrospectively reviewed. Results: Four patients, all boys, age 5 months to 6 years, presented at the acute febrile phase of illness with Dengue Shock Syndrome (severe dengue). Aspartate Transaminase (AST) and Alanine Transaminase (ALT) peaked at day 4-7: median (± 2SD) peak ALT 1871.5 ± 917 u/L, whereas median peak AST 7802.5 ± 5453.8 u/L. Median peak International Normalised Ratio ( INR ), ammonia, lactate were 2.9 ± 1.6, 106 ± 144.6 umol/L, and 7.4 ± 8.4 mmol/L respectively. All patients had hepatomegaly and mild conjugated hyperbilirubinaemia, with median peak total bilirubin 73.5 ± 36.9 umol/L. Two patients received N-Acetylcysteine. One patient received intravenous dexamethasone for dengue associated hemophagocytic lymphohistiocytosis. All recovered fully with supportive treatment based on a well-designed acute liver failure protocol, which comprised of intensive care monitoring, correction of coagulopathy and hypoglycaemia, empirical broad spectrum antibiotic coverage and anti-fungal prophylaxis, gastrointestinal haemorrhage prophylaxis with a histamine-2 receptor antagonist, proton pump inhibitor or sucralfate, and lactulose to reduce hyperammonaemia. Liver function significantly improved (ALT<500 u/L) at a median of 6.5 ± 2 days from onset of liver failure. INR normalized (INR<1.1) at a median of 13.5 ± 6 days of illness. Conclusion: Patients with DFALF can achieve normalisation of liver function and full recovery with early supportive treatment.

Pattern of management and outcome of dengue fever in pediatric in-patients in a tertiary care hospital: a prospective observational study

Background: Dengue is one of the most important mosquito borne viral diseases presenting with varied symptomatology. A broad-angled evaluation with integration of clinical and laboratory parameters would direct the physicians through the stages of the disease process and the line of management. The objectives were to identify the pattern of management of dengue fever in pediatric in-patients and to assess the outcome. Methods: A prospective observational study was carried out in pediatric inpatients. Data were collected by intensive case record review. Patients of age group 1-18 years of both genders diagnosed of dengue fever were included. The prescribing pattern in children presenting at various stages of dengue fever was analyzed. The outcome was assessed in terms of course in hospital and duration of hospital stay . Results: A total of 110 patients diagnosed with dengue fever with one or more warning signs were admitted during the study period. Thirty percent cases had liver enzymes more than 3 times the normal and 68% patients had platelet count &lt;1,00,000/cumm. Two cases of dengue encephalitis were reported. Most common intravenous fluid given was ringer lactate followed by isolyte P and others. Most common antibiotic prescribed was ceftriaxone followed by ampicillin and others. The symptomatic treatment given consisted of paracetamol, anti-acidity drugs and anti-emetic drugs. Vitamin K was prescribed to 41% and zinc and folic acid supplements were prescribed to 30% children. There was no correlation found between vitamin K and outcome of the disease. Conclusion: Antibiotics and vitamin K though not a part of standard World Health Organization guidelines was seen to be an important part of management. Supportive care with judicious fluid management during the critical and recovery period with continuous monitoring is required for all patients. Further comparative studies are needed to establish the role of antibiotics and other supportive measures like zinc and folic acid on the outcome of the disease.

Clinical Profile and Outcome of Dengue Fever from a Tertiary Care Centre at Aurangabad Maharashtra India: An Observational Study

Introduction: India is among the countries reporting regular outbreaks of Dengue infections. The clinical & epidemiological profile of Dengue infection changes from time to time. Present study describes clinical & laboratory manifestations of dengue cases from a tertiary care centre. Methods: It is a descriptive observational study. Study duration was two years from Sep 2011 to Aug 2013. All the dengue patients admitted during this period were included and classified as per new WHO-2009 classification into: Dengue Fever without warning signs (DFWOWS), Dengue Fever with warning signs (DFWWS) and Severe Dengue (SD). The clinical & laboratory parameters were studied and described. Results: From the total of 150 cases, 128 cases (85.33%) were DFWWS, 15 cases (10%) were SD and 7cases (4.67%) were DFWOWS. The commonest age group affected (34 %) was between 11- 15 years. The male: female ratio of cases was 1.73:1. Clinical manifestations were fever (100%), rash (85.33%), arthralgia & myalgia (65.33%), vomiting (64.67%), pain in abdomen (54%), retro orbital pain (43.33%) & convulsions (6.67%). On examination 52% cases had hepatomegaly, 46.67% cases had hemorrhagic manifestations and Tourniquet test was positive in 34.67% of cases. In our study, 54.67% of total cases were positive for NS1 antigen, 28.67% cases were IgM positive and 16.66% cases were positive for both. Maximum number of patients had platelet counts between 40,000 to 1,00,000 (56%). Commonest complication was Encephalitis followed by ARDS. During study period, there was a single death and it was due to ARDS.

English

BACKGROUND AND OBJECTIVES: In recent days there is an alarming increase in the incidence of dengue fever and has emerged as a serious international public health threat with almost half of the world's population at risk for infection. Very few studies have been conducted in this part of our country and hence this study was undertaken to study the clinical picture, laboratory profile and outcome of dengue fever in and around khammam. MATERIALS AND METHODS:A prospective study was conducted over one year at Mamata General Hospital, during which 190 cases were diagnosed as dengue fever which were taken into study and evaluated for clinical, laboratory profile and their outcome. RESULTS: Out of 190 patients taken into study, fever was the most common presentation followed by headache. Thrombocytopenia was seen in 75% of the patients. Bleeding manifestations were seen in patients with platelet counts less than 40000/mm3. 18 patients were diagnosed as DHF, 6 patients were diagnosed as DSS. During our study 10 patients expired. CONCLUSION: The clinical and hematological picture of dengue fever is like any other viral fevers and the bleeding manifestations are seen in patients whose platelet counts decreases less than 40000/mm 3 only.

Presentation, Management and Outcome of Dengue Fever – A Study of 200 Cases

Background: Dengue is the most rapidly spreading mosquito-borne viral disease in the world1. The rapidly expanding global footprint of dengue is a public health challenge. The endemicity of dengue is also increasing in Bangladesh. This study highlights our current understanding of dengue, including its clinical manifestations, laboratory tests, management and outcome. Objectives: This study was designed to document the presenting features and outcome of Dengue infection in Border Guard personnel. Materials and Methods: It was a prospective observational study which was carried out among outpatient and indoor cases from February 2011 to November 2012 in Border Guard Hospital, Dhaka which is a 300 bedded hospital. Total 200 cases were enrolled. A detailed history, clinical examinations and relevant investigations were done. Data were collected in a predesigned structured questionnaire and analyzed with the help of SPSS-16.0 and Chisquare (X2) Test. Results: A total of 200 adult seropositive Dengue cases of various grade were studied. Among these 152(76%) were male and 48 (24%) were female. Male to female ratio was 3.17:1.The age range of the patients was 18 to 60 years and the mean age 39±12.56 years. Among 200 patients, 112(66%) were Dengue Fever (DF) and 88(44%) were Dengue Haemorrhagic Fever (DHF) including 3(1.5%) cases of DHF Grade lII but none (0%) had Grade-IV DHF. All the patients presented with fever 200(100%), general weakness 200(100%) followed by various skin rash 196(98%), headache 192(96%), myalgia/arthralgia 191(95.5%), retroorbital pain 84(42%). Bleeding manifestation showed in 94(47%) cases of which petechiae was most frequent 86(43%), Haematocrit was normal only in 13(6.5%) patients and 82(41%) had a rise of &gt;20%; Leucopenia was found in 187(93.5%) patients.Only 2(1%) patients had normal platelet count and 03(1.5%) patients had platelet count of less than 10X109 /L. Raised serum alanine aminotransferase (ALT) was observed in 184(92%) of cases. All (200%) the patients recovered completely from the disease; however, one patient subsequently developed Guillein Barre Syndrome. Conclusion: High persistent fever, profound general weakness, myalgia, headache and itchy skin rash were the usual presenting features. Most of the patients recovered well with efficient symptomatic and supportive treatment. Very few cases required blood/platelet transfusion. There was no case fatality in this study group DOI: http://dx.doi.org/10.3329/jom.v14i1.14531 J MEDICINE 2013; 14 : 18-22