Abstract

Introduction: In India, Dengue epidemics are becoming more frequent. The majority of dengue virus infection are self limiting, but complications may cause substantial morbidity and mortality. Methods: In this retrospective study, medical records were reviewed and analyzed. Patients were classified into dengue with and without warning sign and severe dengue (DHF/DSS). Objectives: To assess clinical profile of dengue infection in children less than 18 years of age and to evaluate outcome of dengue fever admitted from June to December 2018, in Department of Pediatrics, Sarojini Naidu Medical College, Agra. Results: A total of 50 dengue positive patients were classified into dengue with or without warning signs 42(84%) and 8 (16%) severe dengue cases. The most commonly involved children were male between 5-10 yr (36%) of age group followed by 1-5 yr (34%). Most common clinical manifestation was fever observed in 96% cases followed by rash (66%), pain abdomen (52%) and vomiting in 26% cases.46% cases of dengue had warning signs. Most common clinical and radiological findings were ascites seen in 24% cases followed by pleural effusion. Elevation of Aspartate Transaminase (SGOT) in 82% and thrombocytopenia was seen in 60% cases. Conclusion: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were varying clinical presentation. Early clinical suspicion and diagnosis with prompt management accompanied by preventive measures can prevent morbidity and the mortality associated with dengue.

Highlights

  • In India, Dengue epidemics are becoming more frequent

  • Dengue infections may vary from flu-like self-limiting illness to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which can be fatal, if Manuscript received: 10th March 2019 Reviewed: 20th March 2019 Author Corrected: 25th March 2019 Accepted for Publication: 28th March 2019 left untreated

  • Specific investigations were performed in patients who presented with neurological involvement analysis, neuro-imaging or hepatic failure

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Summary

Introduction

The majority of dengue virus infection are self limiting, but complications may cause substantial morbidity and mortality. Patients were classified into dengue with and without warning sign and severe dengue (DHF/DSS). Results: A total of 50 dengue positive patients were classified into dengue with or without warning signs 42(84%) and 8 (16%) severe dengue cases. Most common clinical manifestation was fever observed in 96% cases followed by rash (66%), pain abdomen (52%) and vomiting in 26% cases.46% cases of dengue had warning signs. Dengue infections may vary from flu-like self-limiting illness to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which can be fatal, if Manuscript received: 10th March 2019 Reviewed: 20th March 2019 Author Corrected: 25th March 2019 Accepted for Publication: 28th March 2019 left untreated. Infection with one serotype of dengue virus (DEN) provides lifelong immunity to that particular serotype, but results only in partial and transient protection against subsequent infection by the other three serotypes

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