To assess whether high- versus low-dose oxytocin regimens for labor augmentation are associated with differential risk for low Apgar score, neonatal acidosis, and other adverse labor outcomes. We searched electronic databases (MEDLINE, EMBASE, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov) from inception up to March 2024 using combinations of the following keywords: "oxytocin," "oxytocin regimen," "oxytocin protocol," "oxytocin dosage," "active management," "high dose protocol," "low dose protocol," "augmentation of labor." We included quasi-randomized and randomized controlled trials comparing continuous oxytocin infusion with high-dose regimens (i.e., intervention group) versus low-dose regimens (i.e., control group) in nulliparous or multiparous patients undergoing augmentation of labor. High-dose regimens were defined as starting oxytocin dose of 4 mU/min or higher and increasing by increments of 3-7 mU/min every 15 to 40 minutes. Low-dose regimens were defined as starting oxytocin dose of less than 4 mU/min and increasing by increments of 1-2 mU/min every 15 to 40 minutes (PROSPERO CRD42024500197). The co-primary outcomes were incidence of Apgar score <7 at 5 minutes and umbilical arterial pH <7.00. Secondary outcomes included cesarean delivery and chorioamnionitis. We performed random-effect head-to-head meta-analyses to compare high- versus low-dose strategies, reporting summary risk ratio (RR) with 95% confidence interval (CI). Ten randomized and quasi-randomized controlled trials of 5,508 total pregnancies met inclusion criteria and were included in the meta-analysis. There was no difference in risk for the co-primary outcomes of Apgar score <7 at 5 minutes (relative risk [RR] 0.94, 95% confidence interval [CI] 0.60-1.46) and umbilical arterial pH <7.00 (RR 0.77, 95% CI 0.50-1.20). There was also no difference in risk for cesarean delivery (RR 0.83, 95% CI 0.67-1.02). High-dose oxytocin regimens were associated with significantly lower risk of chorioamnionitis (RR 0.70, 95% CI 0.57-0.84, number needed to treat=25) and higher risk of tachysystole (RR 1.32, 95% CI 1.21, 1.43; p<0.001). When used for labor augmentation, high-dose oxytocin regimens decrease risk for chorioamnionitis compared to low-dose regimens, without affecting risk for low Apgar score, neonatal acidosis, or cesarean delivery.
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