This manuscript addresses the existing governance tools and monitoring systems for implementing a sustainable and regenerative Bioeconomy in the OECD member states and G20. It takes inspiration from the outcomes of an international workshop entitled “Bioeconomy in the G20 and OECD countries: sharing and comparing the existing national strategies and policies for co-designing more effective bioeconomy governance mechanisms and monitoring systems” co-organized by the Italian Presidency of G20 environment 2021, the National Bioeconomy Coordination Board of the National Committee of Biosafety, Biotechnology and Life Sciences of the Italian Presidency of Council of Ministers and the OECD Working Party on Bio-, Nano- and Converging Technologies. The workshop aimed to share virtuous experiences, identify challenges and co-design more robust governance tools and more comprehensive monitoring systems. The manuscript outlines the current situation regarding governance and monitoring, so as to identify relevant issues and areas for further research and policy action.