Context: Anatomical variations of the grafts are one of the challenging problems in renal transplantation. Among these anatomical variations, multiple renal arteries (MRAs) are considered the most common. Aims: The aim of the study was to find out the outcome of recipient’s receiving multiple artery renal allografts. Settings and Method: This was a single-institutional, prospective, observational study of 212 patients who underwent open live renal allografting after exclusion criteria. All patients were followed up for a minimum of 12 months, and serum creatinine was done at 1 month, 3 months, 6 months, and at 12 months of follow-up. Statistical Analysis Used: Quantitative data have been presented in terms of means and standard deviation. Categorical data have been presented in terms of proportions and percentages. Student’s t-test has been used for the comparison of individual quantitative parameters. Value of P < 0.05 was considered statistically significant. Results: Serum creatinine on the postoperative day-1 was found to be higher in the MRAs group compared to single renal artery (SRA) group (2.25 mg/dl vs. 2.02 mg/dl, P = 0.178). During follow-up of the recipients, there was no statistically significant difference in serum creatinine between the two groups when measured at 1, 3, and 6 months and at 1 year. Conclusions: Outcomes in recipients receiving multiple artery renal allografts were similar compared to the cohort of allografts with SRA. Hence, transplantation of renal allograft with MRAs is safe, and the recipient in need should not be denied of a graft with multiple vessels.