L Grabenhenrich, L Lange, M Hartl. J Allergy Clin Immunol. 2016;137(6):1751–1760.e8 Food challenge remains the gold standard for diagnosing food allergy. Developing alternative tests with improved ability to predict outcomes of food challenges has been elusive. Determining the sensitization to individual proteins, known as component-resolved diagnosis (CRD), has improved models predicting outcomes of food challenges to peanut (Ara h 2–specific IgE) and hazelnut (Cor a 14–specific IgE). The ratio of whole allergen–specific IgE to total IgE has also been investigated for predicting food challenge outcomes. This study aim was to see if the ratio of specific-component IgE to total IgE can improve the prediction of food challenge outcomes. Children referred to 9 pediatric allergy clinics across Germany for a first evaluation of peanut …