Objective: The present study was carried out to describe outcome in acute stroke patients by means of Barthel index (BI) and modified Rankin scale (mRS) treated with neuroprotective agents. Methods: One hundred acute stroke patients were divided into two groups. Group I patients were treated with citicoline as neuroprotective agent and Group II patients were treated with cerebroprotein hydrolysate as neuroprotective agent. BI and mRS were applied at 1st, 3rd, 6th and 12th week respectively. Results: The mean BI at 1st week in Group I was 35.3 and in Group II was 36.2, at 3rd week was 50.5 in Group I and 50.1 in Group II, at 6th week was 61.4 in Group I and 59.8 in Group II and at 12th week was 65.8 in Group I and 64.2 in Group II. The difference was non-significant (p>0.05). The mean mRS at 1st week in Group I was 4.5 and in Group II was 4.2, at 3rd week was 3.6 in Group I and 3.9 in Group II, at 6th week was 3.1 in Group I and 3.6 in Group II and at 12th week was 2.5 in Group I and 2.1 in Group II. The difference was non-significant (p>0.05). Conclusion: A correlation between BI and mRS from baseline to end of 12 weeks within each group was highly significant.