Outbreak In South Korea Research Articles

COVID-19 Impact on Residential Preferences in the Early-Stage Outbreak in South Korea.

In the early stage of the COVID-19 pandemic in South Korea, public fear or social scaring of urban living was observed, which caused people to change their daily routines. This study examines how the COVID-19 pandemic affected residential choice and perceptions of urban living. We analyzed self-reported survey data collected from 2000 participants in Seoul, Daegu, and Kyeongbuk in South Korea between 3–6 August 2020, targeting the relatively controlled period after the first COVID-19 outbreak. Logistic regression models were used to examine concerns of urban living and residence relocation consideration. Those who were aged 30 or older, regularly commuting, not feeling healthy, with a household size of two, and living in a low-rise condominium were more likely to be concerned with urban living. Those who were aged 40 or older and living in a townhouse or a single-detached house were more likely to consider moving to a less dense area. People perceived that their daily routine changed substantially after the pandemic. Certain participant groups showed concerns of urban living and relocation consideration, suggesting housing policy implications.

Is Crisis and Emergency Risk Communication as Effective as Vaccination for Preventing Virus Diffusion? Measuring the Impacts of Failure in CERC with MERS-CoV Outbreak in South Korea.

This study measured the impacts of failure in Crisis and Emergency Risk Communication (CERC) during the outbreak of a contagious Corona viral disease. The study measured the impacts by the number of individuals and hospitals exposed to the virus. The 2015 Middle East Respiratory Syndrome (MERS) outbreak in South Korea was used to investigate the consequences of CERC failure, where the names of hospitals exposed to MERS‐CoV were withheld from the public during the early stage of virus diffusion. Empirical data analyses and simulated model tests were conducted. The findings of analyses and tests show that an early announcement of the hospital names and publicizing the necessary preventive measures could have reduced the rate of infection by approximately 85% and the number of contaminated healthcare facilities by 39% at maximum. This level of reduction is comparable to that of vaccination and of social distancing.

Impact of NPIs for COVID-19 on Other Infectious Diseases and Mental Illnesses in South Korea

Due to COVID-19, high-intensity nonpharmaceutical interventions (NPIs) are implemented and these regulations may trigger changes in the incidence of other infectious diseases. The goal is to determine the impact of NPIs on other infectious diseases and mental illnesses in South Korea. Data were collected from an open-source dataset concerning NPIs covering the period of January 2018 to July 2020. The data comprised average daily mask production volume and number of companies newly authorized to offer disinfection and sterilization services, and numbers of patients with sentinel surveillance infectious disease and mental illness. This study compared changes in NPIs and incidence of infectious diseases and mental illnesses before and after the COVID-19 outbreak in South Korea. 
 In 2020, the average daily mask production volume and the number of companies newly authorized to offer disinfection and sterilization services markedly increased following the virus outbreak (380% and > 94.8–99.5%, respectively). Meanwhile, the incidence of respiratory and intestinal infectious diseases declined, including those of influenza (49–55%), acute respiratory infection (78–79%), hand-foot-and-mouth disease (84–94%), enterovirus (94–97%), and intestinal infectious disease (36–40%). The weekly incidence of sexually transmitted diseases in 2020 remained constant regardless of the COVID-19 outbreak. Meanwhile, the number of outpatients increased by 7–16% for depressive episodes, 5–12% for other anxiety disorders, and 10–28% for sleep disorders. NPIs significantly reduced the incidence of respiratory and intestinal infectious diseases and negatively affected mental health. Therefore, while NPIs should be continued to prevent the spread of infections, systematic policies must be enacted to support mental health.

Comparison of the impact of endoscopic retrograde cholangiopancreatography between pre-COVID-19 and current COVID-19 outbreaks in South Korea: Retrospective survey.

BACKGROUNDThe coronavirus disease 2019 (COVID-19) outbreak has markedly influenced the endoscopic patterns. Endoscopic retrograde cholangiopancreatography (ERCP) is an essential technique for pancreatobiliary disease but increases the risk of exposure to the virus-containing body fluid; however, the impact of COVID-19 on ERCP is unknown. AIMTo compare the number of endoscopic activities and to analyze the clinical outcomes of ERCPs before and during the COVID-19 outbreak in Daegu, South Kore.METHODSThis retrospective cohort study included patients aged ≥ 18 years who underwent ERCP between February 18 and March 28, 2020, at a tertiary hospital. ERCP indications and endoscopic details were compared with those from the same period in 2018 and 2019 as control groups.RESULTSOf the 269 ERCP procedures, 113 (42.0%) cases were performed as emergency procedures. The number of ERCP procedures in 2018 and 2019 decreased by 20.2% and 56.6%, respectively, compared with that in 2020 (P < 0.01); among the 113 emergency ERCPs, the observed numbers in 2018 (n = 42) and 2019 (n = 55) dramatically dropped by 61.9% and 70.9%, respectively, compared with that in 2020 (n = 16). Of the 16 cases in 2020, stone removal was performed in five, biliary stenting in five, sphincterotomy in five, and nasobiliary drainage in one. No case of ERCP-related infection in medical workers or other patients has been reported.CONCLUSIONThe COVID-19 outbreak significantly reduced the number of ERCPs; however, there is no difference in the indications and endoscopic interventions before and during the COVID-19 outbreak.

The multifaceted impact of social media on risk, behavior, and negative emotions during the COVID-19 outbreak in South Korea

ABSTRACT This study examined how social media use is associated with risk perception and social distancing as preventive behavior, which in turn can elicit negative emotions. The study is based on data collected from a nationwide online panel survey conducted during the COVID-19 outbreak in South Korea. Results show that social media use directly and indirectly impacts people’s negative emotions through risk perception and social distancing. The analysis also shows that risk perception and social distancing directly influence negative emotions, which plays a mediating role in the relationship between social media use and negative emotions. The findings of the study provide important implications for effective risk and health communication and health policy during an infectious disease outbreak.

An Optimal Control Analysis of the MERS-CoV Outbreak in South Korea

MERS-CoV is a respiratory disease that originated in the Middle East. This disease is caused by a novel coronavirus which transmits from Dromedary camels to humans, then passed on to other humans through direct contact or droplets. Said to be the biggest to occur outside of Middle East with 186 cases, the outbreak in South Korea should be discussed further. By going through the chain of transmission, it was found that 44\% of the infected individuals were exposed to the virus in the healthcare facilities' environment. To reduce the risk of exposure to the virus, several efforts have been made such as restricting healthcare facilities visitors and increasing the number of isolated individuals in hospitals. The previous study has developed a mathematical model for the outbreak in South Korea and estimated transmission rates from the data provided by the government. In this study, both efforts will be added as control variables to form an optimal control problem to minimize the number of infected individuals and the costs incurred. The optimal control will be obtained using the Pontryagin maximum principle, then simulated using the fourth-order Runge-Kutta forward-backward sweep method for two scenarios to see the effectiveness of both controls. The simulation showed that restricting health facilities visitors to limit the chance of exposure was the most effective strategy to control the MERS-CoV outbreak in South Korea.

COVID-19 and mental health: Anxiety disorders among immigrants due to COVID-19 outbreak in South Korea

BackgroundThe COVID-19 pandemic has affected various facets of health. While mental health became a major concern during the COVID-19 outbreak, the impact on the migrants’ mental health has still been neglected. The purpose of this study was to examine the COVID-19 outbreak's impact on the mental health of immigrants in South Korea.MethodsA total number of 386 immigrants in South Korea participated in this quantitative cross-sectional study. The standardized e-questionnaire, including the General Anxiety Disorder (GAD-7) scale, was used to measure the anxiety level. Logistic regression analysis was performed to find out the determinants of anxiety disorders among immigrants.ResultsThe prevalence of severe anxiety among immigrants was found to be 47.2%. Female immigrants (28.6%) had a lower anxiety disorder than males (71.4%). Immigrants who were married, living alone, had a low income, had a history of health problems were suffered from moderate to severe anxiety. Immigrants who were unemployed (OR 2.302, 95% CI = 1.353–3.917) and lost their jobs due to the COVID-19 outbreak (OR 2.197, 95% CI = 1.312–3.678) have a higher anxiety disorder. Immigrants aged over 30 years were found to suffer from a high level of anxiety (OR 2.285, 95% CI = 1.184–4.410). Relief support from the government was significantly associated with anxiety disorder among immigrants (p < 0.01, OR = 3.151, 95% CI = 1.962–5.061).ConclusionWith very limited studies on immigrants’ mental health during the COVID-19 pandemic, this paper provides scientific research evidence of the COVID-19 outbreak's impact on the mental health of migrants. Our study has consequences for implementing integrated psychological interventions and health promotion strategies for the well-being of immigrants’ mental health.

Modelling the evolution of the coronavirus disease (COVID-19) in Saudi Arabia.

The ongoing COVID-19 pandemic has claimed hundreds of thousands of lives around the world. Health planners are seeking ways to forecast the evolution of the pandemic. In this study, a mathematical model was proposed for Saudi Arabia, the country with the highest reported number of COVID-19 cases in the Arab world. The proposed model was adapted from the model used for the Middle East respiratory syndrome outbreak in South Korea. Using time-dependent parameters, the model incorporated the effects of both population-wide self-protective measures and government actions. Data before and after the government imposed control policies on 3 March 2020 were used to validate the model. Predictions for the disease's progression were provided together with the evaluation of the effectiveness of the mitigation measures implemented by the government and self-protective measures taken by the population. The model predicted that, if the government had continued to implement its strong control measures, then the scale of the pandemic would have decreased by 99% by the end of June 2020. Under the current relaxed policies, the model predicted that the scale of the pandemic will have decreased by 99% by 10 August 2020. The error between the model's predictions and actual data was less than 6.5%. Although the proposed model did not capture all of the effects of human behaviors and government actions, it was validated as a result of its time-dependent parameters. The model's accuracy indicates that it can be used by public health policymakers.

Development, Acceptance, and Concerns Surrounding App-Based Services to Overcome the COVID-19 Outbreak in South Korea: Web-Based Survey Study.

BackgroundSince the COVID-19 outbreak, South Korea has been engaged in various efforts to overcome the pandemic. One of them is to provide app-based COVID-19–related services to the public. As the pandemic continues, a need for various apps has emerged, including COVID-19 apps that can support activities aimed at overcoming the COVID-19 pandemic.ObjectiveWe aimed to determine which apps were considered the most necessary according to users and evaluate the current status of the development of COVID-19–related apps in South Korea. We also aimed to determine users’ acceptance and concerns related to using apps to support activities to combat COVID-19.MethodsWe collected data from 1148 users from a web-based survey conducted between November 11 and December 6, 2020. Basic statistical analysis, multiple response analysis, and the Wilcoxon rank sum test were performed using R software. We then manually classified the current status of the development of COVID-19–related apps.ResultsIn total, 68.4% (785/1148) of the respondents showed high willingness to protect themselves from COVID-19 by using related apps. Users considered the epidemiological investigation app to be the most necessary app (709/1148, 61.8%) overall, followed by the self-management app for self-isolation (613/1148, 53.4%), self-route management app (605/1148, 52.7%), COVID-19 symptom management app (483/1148, 42.1%), COVID-19–related information provision app (339/1148, 29.5%), and mental health management app (270/1148, 23.5%). Despite the high intention to use these apps, users were also concerned about privacy issues and media exposure. Those who had an underlying disease and had experience using COVID-19–related apps showed significantly higher intentions to use those apps (P=.05 and P=.01, respectively).ConclusionsTargeting users is very important in order to design and develop the most necessary apps. Furthermore, to gain the public’s trust and make the apps available to as many people as possible, it is vital to develop diverse apps in which privacy protection is maximized.

Longevity of seropositivity and neutralizing antibodies in recovered MERS patients: a 5-year follow-up study

ObjectivesWe aimed to assess the longevity of spike-specific antibody responses and neutralizing activity in the plasma of recovered Middle East respiratory syndrome (MERS) patients. MethodsWe traced the antibody responses and neutralizing activity against MERS coronavirus (MERS-CoV) in peripheral blood samples collected from 70 recovered MERS patients for 5 years after the 2015 MERS outbreak in South Korea. We also measured the half-life of neutralizing antibody titres in the longitudinal specimens. ResultsThe seropositivity rate persisted for up to 4 years (50.7–56.1%), especially in MERS patients who suffered from severe pneumonia, and then decreased (35.9%) in the fifth year. Although the spike-specific antibody responses decreased gradually, the neutralizing antibody titres decreased more rapidly (half-life: 20 months) in 19 participants without showing negative seroconversion during the study period. Only five (26.3%) participants had neutralizing antibody titres greater than 1/1000 of PRNT50, and a high neutralizing antibody titre over 1/5000 was not detected in the participants at five years after infection. DiscussionThe seropositivity rate of the recovered MERS patients persisted up to 4 years after infection and significantly dropped in the fifth year, whereas the neutralizing antibody titres against MERS-CoV decreased more rapidly and were significantly reduced at 4 years after infection.

Precautionary Behavior Practices and Psychological Characteristics of COVID-19 Patients and Quarantined Persons.

Background: since the coronavirus disease (COVID-19) was first reported in 2019, South Korea has enforced isolation of patients with confirmed cases of COVID-19, as well as quarantine for close contacts of individuals diagnosed with COVID-19 and persons traveling from abroad, in order to contain its spread. Precautionary behavior practices and psychological characteristics of confirmed and quarantined persons were investigated for planning pandemic recovery and preparedness. Methods: this study was conducted with 1716 confirmed patients and quarantined persons in Daegu and Busan, regions where a high number of cases were confirmed during the early stage of the COVID-19 outbreak in South Korea. We collected online survey data from 23 April to 20 May 2020, in Daegu, and 28 April to 27 May 2020, in Busan, in cooperation with Daegu and Busan Infectious Disease Control Centers and public health centers in the regions. COVID-19 symptoms, pre-cautionary behavior practices, psychological states, and the need for improvement in isolation/quarantine environments were examined using an online survey. Results: compared to patients infected with coronavirus, quarantined persons engaged in more hygiene-related behaviors (e.g., hand washing, cough etiquette, and proper mask-wearing) and social distancing. COVID-19 patients had a strong fear of stigma, while quarantined persons had a strong fear of contracting COVID-19. Study participants responded that it was necessary to provide financial support and adequate information during isolation/quarantine. Conclusions: the study highlights the importance of precautionary behavior to prevent COVID-19 infection and the need to provide support (both psychological and financial) to patients and quarantined persons, to reinforce effective communication, social solidarity, and public health emergency preparedness (PHEP) in a pandemic situation.

GOVERNMENT LEGAL ACT COMPARISON BETWEEN INDONESIA AND SOUTH KOREA IN HANDLING COVID-19 PANDEMIC

Coronavirus Disease of 2019 (COVID-19) with the official name of SARS-CoV-2 has been a serious emerging alert for countries around the world, which makes it a global outbreak of respiratory illness caused by a novel (new) coronavirus. Some countries did a remarkable job on flatten their COVID-19 case rate curve, the finest world reputation in handling this pandemic is given to the Republic of Korea or more known as South Korea which has amazed other world leaders wondering how Moon Jae-in, current President of South Korea, has successfully implied effective and accurate strategies in handling this world outbreak in South Korea. Asides from South Korea succeed, there are some countries who are fall way behind such as the Republic of Indonesia who is currently concerning not only in the medical sector, but the emerging economic sector is severely impacted which leaves us a solicitous feeling towards the future of our nation. In this case, a comparative study is needed to reflect on what has not yet done right. This paper discusses what sort of precise policy reconstructions should be adapted by the Indonesian government from the South Korean government’s effective strategy accuracy in handling COVID-19.

Trends in recent waterborne and foodborne disease outbreaks in South Korea, 2015-2019.

ObjectivesThis study analyzed trends in foodborne and waterborne diseases in South Korea between 2015 and 2019.MethodsThe data consisted of information on outbreaks of waterborne and foodborne infectious diseases reported through the Korea Centers for Disease Control and Prevention (KCDC) system. We analyzed the trends and epidemiological aspects of outbreaks by month, place of occurrence, and causative pathogens in this observational study.ResultsThe number of outbreaks has steadily increased over the last 5 years, but the number of cases per outbreak has followed a decreasing trend. Incidence at daycare centers and preschools has been steadily increasing over consecutive years.ConclusionThe steady number of patients and decreasing number of cases per outbreak, even as the number of outbreaks has been increasing, suggest that the KCDC’s professional management system is operating effectively. It is necessary to continue improving the objectivity and efficiency of the management system and to carefully examine the increasing number of outbreaks in smaller-scale group catering facilities, such as daycare centers and preschools. Outbreaks can be prevented by closely examining those caused by unidentified pathogens and group outbreaks caused by other diseases, identifying problems, and supplementing the management system.

The Role of Event-Related Rumination and Perceived Social Support on Psychological Distress during the COVID-19 Pandemic: Results from Greater Daegu Region in South Korea.

ObjectiveResearch on psychological distress from the coronavirus disease 2019 (COVID-19) crisis has increased significantly, but the factors that can exacerbate or mitigate such distress have remained underexplored. To address the research gap, this study examined whether two types of rumination and perceived social support predict psychological distress during the pandemic. MethodsParticipants were recruited from communities of the greater Daegu area (n=316) where the first massive outbreak in South Korea occurred and most residents underwent substantial disruption of daily life. They completed self-report questionnaires that included measures of psychological distress, event-related rumination, and social support. ResultsThe hierarchical regression analysis showed that maladaptive intrusive rumination and perceived social support predicted increases and decreases in psychological distress, respectively, even when subjective severity of COVID-19-related experiences was controlled. Putatively adaptive type of rumination (i.e., deliberate rumination) was not a significant predictor concurrently. ConclusionThis is among the early endeavors to comprehensively understand risk and protective factors associated with an effective coping strategy against the COVID-19 crisis. Our results indicate that intrusive rumination aggravates but social support mitigates psychological distress during the pandemic, indicating that we can better adapt by differently attending to recent experiences and maintaining perceived social support.

Differences in seroprevalence between epicenter and non-epicenter areas of the COVID-19 outbreak in South Korea.

To compare the standardized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence of high epicenter region with non-epicenter region, serological studies were performed with a total of 3,268 sera from Daegu City and 3,981 sera from Chungbuk Province. Indirect immunofluorescence assay (IFA) for SARS-CoV-2 IgG results showed a high seroprevalence rate in the Daegu City (epicenter) compared with a non-epicenter area (Chungbuk Province) (1.27% vs. 0.91%, P = 0.0358). It is noteworthy that the highest seroprevalence in Daegu City was found in elderly patients (70’s) whereas young adult patients (20’s) in Chungbuk Province showed the highest seroprevalence. Neutralizing antibody (NAb) titers were found in three samples from Daegu City (3/3, 268, 0.09%) while none of the samples from Chungbuk Province were NAb positive. These results demonstrated that even following the large outbreak, the seropositive rate of SARS-CoV-2 in the general population remained low in South Korea.

Factors Associated With Post-traumatic Growth Among Healthcare Workers Who Experienced the Outbreak of MERS Virus in South Korea: A Mixed-Method Study.

Background: Infectious disease outbreaks such as COVID-19 and MERS pose a major threat to healthcare workers' (HCWs) physical and mental health. Studies exploring the positive changes gained from adapting to traumatic events, known as post-traumatic growth (PTG), have attracted much attention. However, it is unclear which factors or experiences lead to PTG among HCWs. The purpose of this mixed-method study was to investigate factors associated with PTG among HCWs who experienced the MERS outbreak in South Korea, and fully describe their experience of developing PTG.Methods: Quantitative data from 78 participants were collected using psychometric tools for Psychological distress, Resilience, and Support for coping, and Post-traumatic growth. Qualitative interviews were conducted with seven nurses. Data were analyzed using the qualitative content analysis method according to the sub-themes of resilience, which was the main factor associated with PTG.Results: We found resilience to have a significant impact on PTG (ß =0.486, p = 0.001). Thus the qualitative interviews were analyzed using the core concepts of resilience. Qualitative interviews with nurses illustrated how participants experienced the development of resilience in terms of its sub-factors: hardiness, persistence, optimism, and support.Conclusion: HCWs who endured the MERS outbreak showed high levels of PTG, and the analysis of the interview data provided a fuller understanding on the experience of remaining resilient and developing PTG. These results provide practical and pragmatic information helpful for developing intervention strategies and protocols that can help HCWs transform adversity into growth and development.

Pandemic and hospital avoidance: Evidence from the 2015 Middle East respiratory syndrome outbreak in South Korea

Existing literature shows that people exhibit disease avoidance behaviors in response to contagious disease outbreaks. We examine hospital avoidance behaviors during the 2015 Middle East respiratory syndrome (MERS) outbreak in South Korea. The outbreak provides an excellent setting for the analysis because unlike the coronavirus disease-19 (COVID-19) situation, no mandatory lockdown was imposed during the outbreak, and the economic impact was also not large. Hence, reduced hospital visits are likely to reflect the public’s intention to avoid hospitals to protect themselves from getting infected with MERS. Moreover, the outbreak did not spread to the entire country and vanished after a short period of time, allowing us to consider the affected regions as the treatment group and the other regions as the control group without much concern of confounding by other factors. The data come from a government agency, which assesses (national) health insurance claims made by hospitals, and hence cover all outpatient visits in the country. We find that people reduced outpatient visits by about 17% in response to the MERS outbreak, and the response was the most intense when new cases were reported most frequently.

Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in Jordan.

Middle East respiratory syndrome-related coronavirus (MERS-CoV) is a persistent zoonotic pathogen with frequent spillover from dromedary camels to humans in the Arabian Peninsula, resulting in limited outbreaks of MERS with a high case-fatality rate. Full genome sequence data from camel-derived MERS-CoV variants show diverse lineages circulating in domestic camels with frequent recombination. More than 90% of the available full MERS-CoV genome sequences derived from camels are from just two countries, the Kingdom of Saudi Arabia (KSA) and United Arab Emirates (UAE). In this study, we employ a novel method to amplify and sequence the partial MERS-CoV genome with high sensitivity from nasal swabs of infected camels. We recovered more than 99% of the MERS-CoV genome from field-collected samples with greater than 500 TCID50 equivalent per nasal swab from camel herds sampled in Jordan in May 2016. Our subsequent analyses of 14 camel-derived MERS-CoV genomes show a striking lack of genetic diversity circulating in Jordan camels relative to MERS-CoV genome sequences derived from large camel markets in KSA and UAE. The low genetic diversity detected in Jordan camels during our study is consistent with a lack of endemic circulation in these camel herds and reflective of data from MERS outbreaks in humans dominated by nosocomial transmission following a single introduction as reported during the 2015 MERS outbreak in South Korea. Our data suggest transmission of MERS-CoV among two camel herds in Jordan in 2016 following a single introduction event.

The Role of Coping Strategies in Maintaining Well-Being During the COVID-19 Outbreak in South Korea

The COVID-19 pandemic continues to pose an unprecedented challenge for the world as people strive to cope with this significant threat to their well-being. This intensive longitudinal study of the first 94 days of the COVID-19 outbreak in South Korea (Phase 1: initial outbreak, Phase 2: intense social distancing) examined individuals’ changes in well-being, in relation to their use of coping strategies and fear of infection. A sample of 10,464 South Koreans participated in surveys during Phase 1 and Phase 2, resulting in 35,846 observations. Multilevel growth models revealed a decrease in well-being while different coping strategies moderated the individual rate of change in well-being. Although preventive measures were associated with a greater decrease in well-being, cognitive appraisal and behavioral strategies predicted stable well-being during the pandemic. Coping strategies further mediated the association between fear of infection and deterioration of well-being.

Assessing the Effectiveness of Isolation and Contact-Tracing Interventions for Early Transmission Dynamics of COVID-19 in South Korea.

Recent COVID-19 outbreaks pose serious public health challenges all around the world. South Korea had experienced the early outbreak of the COVID-19 pandemic and implemented early effective interventions. The 2020 COVID-19 outbreak in South Korea showed spatial hot spots and super-spreading events. As a result of these super-spreading events, three huge outbreaks of the COVID-19 have occurred in Korea from February to December 2020. To capture the intrinsic nature of heterogeneity, an agent-based model has been developed focusing on early transmission dynamics of COVID-19 in South Korea. Based on the social empirical contact information of early confirmed cases of COVID-19, we have constructed a scale-free network. Our agent-based model has incorporated essential individual variability such as different contact numbers and infectivity levels. In the absence of vaccines or treatment, contact tracing, case-isolation, quarantine are the most critical interventions to prevent larger outbreaks. First, we investigate the impacts of critical factors on various epidemic outputs such as incidence and cumulative incidence. These critical factors include contact numbers, transmission rates, infectivity of presymptomatic or asymptomatic cases, and contact-tracing with quarantine intervention. Furthermore, the effectiveness of case isolation and contact-tracing (followed by quarantine) is evaluated under various scenarios. Our results indicate that case isolation combined with contact-tracing quarantine is much more effective under a moderate level of n}{}mathcal R_{0}n (smaller transmission rates or contact numbers) and presymptomatic cases. However, the efficacy of interventions reduces significantly for a higher level of n}{}mathcal R_{0}n (larger transmission rates or contact numbers) with a high level of infectivity (in presymptomatic cases). This highlights the key role of efficient contact-tracing and case-isolation to mitigate larger outbreaks or super-spreading events.