Evolution of new viruses and their spread across continents are worrisome due to high mortality rates. One of the greatest advantages of handling epidemics and pandemics of H1N1 is the existing global preparedness, public awareness and vaccine availability for this virus. Media and health departments of various countries play a pivotal role in disseminating knowledge as soon as an outbreak is suspected. Currently, H1N1 is easily detectable and controllable compared to other types of Influenza viruses, therefore reducing the anxiety among the public as well as health-care workers. This review would give a comprehensive understanding of clinical manifestations, diagnostic strategies and infection control practices, which should be followed to effectively manage outbreaks of H1N1.