Osteoporotic Bone Marrow Defect Research Articles

Focal osteoporotic bone marrow defect: A happenstance finding

Abstract Focal osteoporotic bone marrow defects (FOBMDs) of jaws are rare and usually discovered as an incidental radiographic finding. They present as a poorly demarcated radiolucency affecting the posterior mandible of middle-aged women with pathogenesis remaining unknown. A 60-year-old female patient had visited our dental college for routine dental checkup and oral prophylaxis. Her radiograph revealed a well-defined radiolucency in the left mandibular posterior region as an incidental finding. Clinical examination revealed a diffuse swelling in the above-mentioned region which the patient had not noticed. The patient gave a history of trauma in the same region almost 20 years back. Incisional biopsy was performed. Microscopic examination revealed multiple bits of fatty fibro cellular tissue resembling the bone marrow with aggregates of blood cells. A diagnosis of FOBMD was given. FOBMD, although rare, should be included in differential diagnosis of the radiolucent lesions of the jaws.

Ultrasound Sonography to Detect Focal Osteoporotic Jawbone Marrow Defects Clinical Comparative Study with Corresponding Hounsfield Units and RANTES/CCL5 Expression.

IntroductionThe presently used impulse echo ultrasound examination is not suitable to provide relevant and reliable information about the jawbone, because ultrasound (US) almost completely reflects from the hard cortical jawbone. At the same time, “focal osteoporotic bone marrow defects” (BoneMarrowDefects = BMD) in jawbone are the subject of scientific presentations and discussions.PurposeCan a newly developed trans-alveolar ultrasonic sonography (TAU-n) device locate and ascertain BMD?Patients and MethodsTAU-n consists of a two-part handpiece with an extraoral ultrasound transmitter and an intraoral ultrasound receiver. The TAU-n computer display shows the different jawbone densities with corresponding colour coding. The changes in jawbone density are also displayed numerically. The validation of TAU-n readings: A usual orthopantomogram (2D-OPG) on its own is not suitable for unequivocally determining jawbone density and has to be excluded from this validation. For validation, a 3D-digital volume tomogram@/cone beam computer tomogram (DVT@/CBCT) with the capacity to measure Hounsfield units (HU) and a TAU-n are used to determine the presence of preoperative BMD in 82 patient cases. Postoperatively, histology samples and multiplex analysis of RANTES@/CCL5 (R@/C) expression derived from surgically cleaned BMD areas are evaluated.ResultsIn all 82 bone samples, DVT-HU, TAU-n values and R/C expressions show the presence of BMD with chronic inflammatory character. However, five histology samples showed no evidence of BMD. All four evaluation criteria (DVT-HU, TAU-n, R/C, histology) confirm the presence of BMD in each of the 82 samples.ConclusionThe TAU-n method almost completely matches the diagnostic reliability of the other methods. The newly developed TAU-n scanner is a reliable and radiation-free option to detect BMD.

A Bizarre Presentation of Bilateral Mandibular Osteoporotic Bone Marrow Defect (A Case Report)

BACKGROUND: Osteoporotic bone marrow defect of the jaw is an uncommon localized radiolucency that consists of hematopoietic red marrow with varying amounts of fatty yellow marrow. The lesion is usually asymptomatic and accidentally discovered during a routine radiographic examination; however, some studies showed different results.
 CASE REPORT: This is an uncommon case of bilateral mandibular osteoporotic bone marrow defect in a 40-year- old healthy female. One of the defects reoccurred, and it involves dental implants. 
 PLAN OF TREATMENT: Lesion was managed by curettage and the patient was followed up after 1,6,12 months.
 CONCLUSIONS: in order to diagnose FOBMD and differentiate it from other lesions, further researches are needed to help fully understand it, since the exact incident and etiology are not established yet.

A Case of Focal Osteoporotic Bone Marrow Defect of the Mandible

A Case of Focal Osteoporotic Bone Marrow Defect of the Mandible

FOCAL OSTEOPOROTIC BONE MARROW DEFECT: REPORT OF THREE DISTINCT CASES

Focal osteoporotic bone marrow defect (FOBMD) is an unusual aspect found in different regions of the jaw. Most of the cases are discovered in a routine radiographic analysis for oral conditions evaluations. The diagnosis of FOBMD is considered a challenge because it shows the same features of other lesions in the jaws. However, a definitive diagnosis could be established only based on the histopathologic patterns. In this study, 3 cases of FOBMD are presented approaching the clinical, radiologic and histopathologic aspects. All the cases were reported with patients that were looking to implant placements. After following the exams, FOBMD was found as a radiolucent area in mandible and the biopsy confirmed the diagnoses.

Dental implant placement in focal osteoporotic bone marrow defect: A case report

Dental implant placement in focal osteoporotic bone marrow defect: A case report

Focal osteoporotic bone marrow defect involving dental implant: a case report.

In oral implantology, the most serious complications occur intraoperatively or within a short period. We describe an unusual case of focal osteoporotic bone marrow defect involving dental implant in the posterior mandibular region of the adult woman. Despite the fact that this condition requires no treatment, it could lead to the displacement of the dental implant. Additionally, this case report reinforces that histopathological analysis is mandatory for precise diagnosis of the radiolucency into posterior mandibular region of the adult woman associated or not with dental implant placement.

Case Presentation of Osseous Dysplasia With Concomitant Focal Osteoporotic Bone Marrow Defect in The Mandible

Case Presentation of Osseous Dysplasia With Concomitant Focal Osteoporotic Bone Marrow Defect in The Mandible

Focal Osteoporotic Bone Marrow Defects: Case Report

The diagnosis of focal osteoporotic bone marrow defects is important because this variation show radiographic characteristics that could be misinterpreted as other lesions. Woman, 43, was referred to the FOUERJ Clinic of Oral Medicine by her dentist based on radiographs taken before implants were placed. Two panoramic radiographs, dated 2011 and 2012, both presented a radiolucent image that was multiloculated and located in the area from tooth #37 to tooth #44 that maintained the same size. There were no clinical manifestations, so it was concluded that the image was caused by focal osteoporotic bone marrow defects.

Displacement of Dental Implant Into The Focal Osteoporotic Bone Marrow Defect

Focal osteoporotic bone marrow defects of the jaws are asymptomatic radiolucent lesions that occur predominantly in the molar region of middle-aged women. Woman, 83, was referred to a private clinic for an implant rehabilitation treatment. Radiographically, a radiolucent area around the implant in the molar region was observed. A biopsy specimen underwent histopathological analysis, which revealed hematopoietic bone marrow characterized by granulocytes, monocytes, and lymphocytes. In addition, megakaryocytes, erythrocytes, fat cells, and irregular fragments of bone tissue were also detected.

Displacement of dental implants into the focal osteoporotic bone marrow defect: a report of three cases

Focal osteoporotic bone marrow defect (FOBMD) is a radiolucent area corresponding to the presence of hematopoietic tissue rarely found in the jaws. FOBMD is most commonly located in the mandibular edentulous posterior area of a middle-aged female. From November 2011 to November 2012, we experienced three cases involving removal of implants that had accidentally fallen into the FOBMD area. All patients happened to be female, with a mean age of 54 years (range: 51-60 years). One case involved hypoesthesia of the lower lip and chin, while two cases healed without any complication. Displacement of an implant into the FOBMD area is an unusual event, which occurs rarely during placement of a dental fixture. The purpose of this study was to report on three cases of FOBMD and to provide a review of related literature.

Bilateral osteoporotic bone marrow defects of the mandible: a case report

Osteoporotic bone marrow defect of the jaws has been reported as a poorly demarcated radiolucency that affect mainly posterior mandible of middle-aged woman. The incidence of this condition is not exactly established and its pathogenesis remains unknown. An additional unusual case of osteoporotic bone marrow defects occurring bilaterally in the mandibular edentulous regions of a 32-year-old white woman is presented reinforcing its diagnostic criteria and histopathological findings.

下顎に発生したOsteoporotic Bone Marrow Defect の1例

Osteoporotic bone marrow defect （OBMD） is a rare benign jaw lesion consisting of hematopoietic bone marrow, which results in a focal bone defect. The present report describes a case of OBMD in the mandibular molar region of a 53 year-old-woman. A panoramic radiograph showed the presence of an undefined round,thumb-sized radiolucent lesion in the lower left first molar region. The density inside of the lesion was −37.7 Hounsfield units on CT scanning, suggesting fat tissue. The biopsy specimens revealed fat tissue with thin bone trabeculae and hematopoietic cell infiltration. The clinical course has been uneventful without any treatment for 4 years.

Focal Osteoporotic Bone Marrow Defect Of The Mandible. Case Report

The focal osteoporotic bone marrow defect is a rare condition of the jaws. Preferably, the lesion affect middle-age woman and is most commonly seen in the posterior mandible. In most cases, the lesion is asymptomatic and discovered as an incidental radiographic finding. This paper describes a case of this condition in a 46-year-old woman that related trauma to the mandible 20 years ago. O defeito osteoporótico focal da medula é uma condição rara dos maxilares. Preferencialmente, afeta mulheres na meia-idade e é mais comumente observado na região posterior de mandíbula. Na maioria dos casos, a lesão é assintomática e descoberta como um achado radiográfico incidental. Este trabalho descreve um caso desta condição em uma mulher de 46 anos de idade com história de trauma na mandíbula há cerca de 20 anos.

Focal osteoporotic bone marrow defects associated with a cystic change of the maxilla: a possible histopathogenetic background of simple bone cyst

A case of focal osteoporotic bone marrow defects (FOBMDs) with a simple bone cyst-like change arising in the bilateral anterior maxilla of a 9-year-old Japanese boy is reported. Two FOBMD lesions were simultaneously found by chance as small oval-shaped unilocular radiolucencies symmetrically located between the canines and lateral incisors on a panorama radiograph during dental treatment of the patient's right maxillary canine, which erupted obliquely as the canine tooth roots were laterally displaced by the lesions. The lesions were surgically extirpated under a clinical diagnosis of developmental jaw cysts. However, they were shown at surgery not to be cysts but instead bone-marrow-like tissues, though the right lesion contained a cavity space within it. Histopathologically, they were fatty marrow without hematopoiesis, and irregularly-shaped bony trabeculae and blood clots were seen scattered throughout the marrow. They were diagnosed as FOBMD (left) or FOBMD with simple bone cyst (right), although they did not contain hematopoietic marrows. Thus, their fully fatty change with some blood pools suggests that they were in the initial stage of developing into simple bone cysts. Based on these histological observations, we propose a new hypothesis of FOBMD as one of the histopathogenetic precursors of simple bone cyst.

Foyers d’hématopoïèse intramandibulaire. Une pathologie méconnue

Focal hematopoietic bone marrow defect of the mandible is a little documented benign jaw lesion. It is usually diagnosed fortuitously by orthopantomography. A 48-year-old woman was referred by her dentist for radiolucency of the molar mandibular region. This could be observed on the panoramic view as an osteoporotic lesion, located in the molar region and not well delimited. The CT scan confirmed the fact that the lesion did not affect the corticals. The biopsy confirmed the diagnosis of focal osteoporotic bone marrow defect of the mandible. These lesions have been described for more than 70 years. These benign lesions, often discovered fortuitously, mainly affect women between 40 and 60 years of age. They are mostly located in the "molar area" where tooth avulsion was previously performed, and share the same clinical and radiographic features. Nevertheless, surgical biopsy is needed to confirm the diagnosis.

Focal osteoporotic bone marrow defect in the anterior maxilla

An unusual presentation of a focal osteoporotic bone marrow defect is documented. A definitive diagnosis could not be established on the basis of the location, history, clinical, and radiographic appearance. A biopsy provided the identity of the lesion.

Osteoporotic bone marrow defect of the mandible: Report of a case diagnosed by computed tomography scanning

Osteoporotic bone marrow defects (OBMD) of the jaw have been described by some authors.‘.” The etiology is controversial and Barker” has mentioned three factors that could be involved. However, the etiology still remains unknown in the vast majority of cases.3 Because the lesion is asymptomatic, it is usually discovered on a routine radiographic examination. The radiographic appearance of OBMD varies from radiolucencies with well-defined borders to the more common radiolucencies with ragged, poorly marginated borders3 The differential diagnosis includes a wide range of lesions, and diagnosis is usually based on histologic findings. ‘.2.4 This report describes a case in which computed tomography (CT) scanning was used as a means of making an accurate diagnosis.

Osteoporotic bone marrow defect: Radiographic features and pathogenic factors

The literature on osteoporotic bone marrow defect (OBMD) is reviewed, and an analysis of 20 additional cases is presented. The findings in this study are consistent with previous reports that the radiographic appearance may be indistinguishable from that of pathologic conditions; in some cases, the condition may be confused with aggressive tumors. It may also be significant that, in 16 of our 20 cases, the defects were found in regions where there had been previous extractions.

Focal osteoporotic bone marrow defects of the jaws

Twenty focal osteoporotic bone marrow defects of the jaws were analyzed clinically, histologically, and radiographically; the findings were compared with those from all known published cases. Radiologic and clinical criteria that are useful for making a definitive diagnosis are discussed, and five radiologic categories are proposed.