Long-term osteomyelitis of the jaws is usually a manifestation of an acute or a chronic inflammatory process in the medullary spaces or cortical surfaces of bone that extends away from the initial site of involvement. The main pathogen is usually bacteria found in the oral cavity. There are several predisposing factors such as chronic systemic diseases and immunocompromised status. Chronic osteomyelitis predominates in alcoholic males, mostly in the mandibular region. Antibiotics are used as a cornerstone of treatment; however, surgical approach is mandatory when there is no clinical improvement, this may consist of sequesterectomy, decortication, or even complete osteotectomy of the infected bone. Nontuberculous mycobacterium (NTM), known as Mycobacterium abscessus, is part of the rapidly growing Mycobacteria family. This new entity is known to be responsible for several types of infections after surgical procedures including mammoplasty, facelifts, and intramuscular injections. Osteomyelitis due to NTM is usually secondary to trauma or exposure to infected objects. In the article, we present an unusual case of osteomyelitis of the mandible in a healthy young woman after she underwent dental treatment. After reviewing the literature regarding this subject, we concluded that this is the first documented case of osteomyelitis of the mandible caused by M abscessus. However, there are several reports of M abscessus–related infections in the facial region and skull base, especially after facelift procedures, penetrating orbital trauma, and chronic mastoiditis; none of them, however, involve osteomyelitis.