Osteoarthritis In Chinese Population Research Articles

Rs11728697 and rs4754 in SPP1 affect the susceptibility to knee osteoarthritis in Chinese population

Rs11728697 and rs4754 in SPP1 affect the susceptibility to knee osteoarthritis in Chinese population

Classification and Morphological Parameters of the Calcaneal Talar Facet: Which Type Is More Likely to Cause Osteoarthritis in Chinese Population?

Due to the calcaneal osteoarthritis, patients had a lower quality of life. This research was to study which type of calcaneus was more likely to cause osteoarthritis and then to guide the clinical prevention and treatment in Chinese population. All 505 intact Chinese calcaneus facets were reconstructed by CT-3D reconstruction scanner and classified into five types based on the calcaneal talar facet (CTF) configuration. CTF's morphology parameters (osteophyte, cortical thickness of calcaneus, GIssane's and Bohler's angle, and long and short axis) were measured and recorded by PACS CT system. Researchers used the length of long and short axis to calculate the CTF area. By comparing the morphology parameters of five types of calcaneus, the differences among different types of calcaneus in Chinese people were statistically different. The study showed that Type II and Type IV had the highest percentage of osteophytes. After being compared and analyzed, the CTF pressure and the subtalar joint stability were closely related to the occurrence of osteoarthritis. Based on the measurement and comparison of morphological parameters in this study, Types II and IV were the most likely to develop osteoarthritis in Chinese population.

Relationship between ADAMTS14/rs4747096 gene polymorphism and knee osteoarthritis in Chinese population.

To investigate the association between single nucleotide polymorphisms (SNPs) of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 14 (ADAMTS14) gene and susceptibility to knee osteoarthritis (KOA) in Chinese Han population. Using a case–control design, we enrolled 346 KOA patients and 480 healthy controls. Peripheral blood samples were extracted from each subject. Genotype was determined by sequencing PCR products. The genotype frequencies between cases and controls were compared. The genotype distribution was in accordance with Hardy–Weinberg equilibrium. The minor G allele in case group was significantly higher than in the control group (21.4 compared with 8.8%, P=0.000, odds ratio (OR) = 1.71 (95% confidence interval (CI): 1.39–2.11). The GG genotype and the GG/AG combination were more common in the osteoarthritis (OA) group than in the control group. Compared with AA genotype, the GG (OR = 3.09, 95%CI: 2.01–4.75), AG (OR = 2.55, 95%CI: 1.64–3.96), and GG/AG (OR = 1.57, 95%CI: 1.19–2.07) increased the risk of OA. Multiple logistic confirmed the findings by adjusting some potential factors. Subgroup analysis indicated that the ras4747096 was still significantly associated with KOA. There were no significant differences in allele frequency or genotypes frequency for erythrocyte sedimentation rate and C-reaction protein in OA patients (P>0.05). ADAMTS14 gene polymorphism was associated with KOA, and the GG genotype increased the risk of KOA in Chinese Han population. The ADAMTS14 may be a diagnostic marker and therapeutic target for KOA treatment. The future study should explore the specific molecular mechanism.

The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk.

Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47–3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15–2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26–2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20–1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case–control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population.

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study

Purpose: To explore the cross-sectional association between knee Osteoarthritis (OA) and bone metabolism in adults. Methods: A cross-sectional sample of 2812 female residents living in Lujiazui and Longhua distincts of Shanghai (range 45–80 years old) was included from July of 2015 to February of 2016. Data collection including basic characteristic, disease history and other information was performed by physicians from Longhua Hospital via a face-to-face interview. Lumbar Bone Mineral Density (BMD) was measured by using dual-energy X-ray absorptiometry by a qualified technician. Fasting blood was collected and bone metabolic biochemical markers were detected by third-party medical laboratory company. A multivariable logistic analysis model was applied to test the relationship between lumbar BMD and knee OA. Results: One thousand and ninety-five knee OA patients were analyzed in total. Four hundred and fifty-six (41.6%) patients suffered osteopenia and 346 (31.6%) also had osteoporosis (OP) in knee OA group. Age, Body Mass Index (BMI), chronic diarrhea and vitamin D were determined as potential confounders by data mining. After adjustment for them, lumbar BMD [OR (95%CI):0.43(0.26, 0.72), P = 0.0013] and lumbar BMD T-scores [OR (95%CI): 0.90(0.85, 0.95), P = 0.0002] were negatively associated with knee OA. In contrast, the prevalence of knee OA was significantly higher in the osteopenia group [OR (95%CI):1.12 (0.93, 1.35), P = 0.2356] and the OP group [OR (95%CI):1.28(1.05, 1.57), P = 0.0157] than in the normal group. The OR (95%CI) for trend was 1.13(1.02, 1.25), P = 0.0157. After adjusted the potential confounders, people who expressed higher B-CTX held greater risk to suffer KOA by 66% [OR (95%CI) P: 1.66 (1.07, 2.57) 0.0237]. There were two kinds tendency appeared in fitted curve. KOA increased with B-CTX augment before and decreased after turning point (B-CTX = 0.3 ng/mL),[ BCTX<0.3 ng/mL OR (95%CI) P: 1.34 (1.17, 1.54) <0.0001, B-CTX>0.3 ng/mL OR (95%CI) P: 0.96 (0.90, 1.03) 0.2317. Data was the effect size of B-CTX on KOA with per 0.1 ng/mL (100 pg/mL) change.]. Conclusions: It was the first time for us to conclude that a higher lumbar BMD was independent protective factor for knee OA in Chinese population, and we firstly found that B-CTX played different roles in KOA progression. When the concentration of serum B-CTX was less than 0.3 ng/mL, it was a risk factor to KOA, but when it was higher than 0.3 ng/mL, it was on the contrary. The study providing an unambiguous evidence for knee OA research and clinical treatment.View Large Image Figure ViewerDownload Hi-res image Download (PPT)View Large Image Figure ViewerDownload Hi-res image Download (PPT)View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Relationship between cigarette smoking and radiographic knee osteoarthritis in Chinese population: a cross-sectional study.

The purpose of this paper was to estimate the cross-sectional association between cigarette smoking and radiographic knee Osteoarthritis (OA) in Chinese population. A total of 3,789 subjects (1,796 females and 1,993 males) participated in this study. A subject was diagnosed with radiographic knee OA if Kellgren-Lawrence (K-L) grade ≥2 in at least one leg. The smoking status was classified into four levels based on the daily smoking habit: (1) 0/day; (2) 1-10/day; (3) 11-20/day; and (4) >20/day. Linear trend and multivariable logistic regression were conducted for statistical analysis. The prevalence of radiographic knee OA was 28.4% among the subjects of this study. An inverse association was observed between cigarette smoking and radiographic knee OA in the linear trend test. Such association remained valid after adjusting the factors of age, gender, body mass index, betel quilt chewing status, physical activity, alcohol drinking status, mean total energy intake and educational level in the multivariable logistic regression. This study suggested a negative association between cigarette smoking and radiographic knee OA in the Chinese population. The findings of this study need to be confirmed by further prospective research.

Association of PPARγ gene polymorphisms with osteoarthritis in a southeast Chinese population.

Primary osteoarthritis (OA) is a leading cause of disability in developed countries. Currently no satisfactory treatment to stop disease progression exists. Recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is an interesting therapeutic target for this disease. PPARγ is a transcription factor important for adipogenesis and adipocyte differentiation. Agonists of PPARγ inhibit inflammation and reduce generation of cartilage degradation products both in vitro and in vivo, and reduce the development/progression of cartilage lesions in OA animal models. However, there are no studies to assess the role of PPARγ in OA susceptibility of human peripheral joints in a Chinese population. We conducted a case-control study in a southeast Chinese population to determine the association of PPARγ gene polymorphisms (rs1801282, rs12629751, rs2292101, rs4135275 and rs1175543) with OA. One-hundred knee OA cases and 100 controls were studied. Statistically significant differences were detected in genotype and allele frequencies between OA and control groups in this population. For knee OA, the highest risk was associated with the variant allele T of the single nucleotide polymorphism rs12629751 (odds ratio (OR): 0.341, 95% confidence interval (CI):0.173-0.673, P = 0.002), and allele T of SNP rs12629751 (chi-square: 9.546, P = 0.002) could be considered as a risk factor of knee OA. Therefore, PPARγ mutation could be associated with the incidence of OA in a Chinese population. There is a significant association between the PPARγ polymorphism rs12629751 and susceptibility to knee OA in a southeast Chinese population.

The Interaction Between Obesity and RAGE Polymorphisms on the Risk of Knee Osteoarthritis in Chinese Population

Background: The receptor for advanced glycation end products (RAGE) has been reported to relate to osteoarthritis (OA), however, the role of RAGE genetic variants in OA remains unknown. Method: A total of 233 patients with primary knee OA and 255 healthy volunteer were recruited. Three RAGE gene polymorphisms, namely, Gly82Ser (rs2070600). -374T/A (rs1800624) and 429T/C (rs1800625) were genotyped. Results: Of all three RAGE gene polymorphisms, only the genotype distributions and alleles frequencies of 82G/S polymorphisms significantly differed between knee OA and control subjects. The presence of SS genotype and S allele of 82G/S we significantly higher in knee OA subjects than in controls (34.76% vs. 19.61%, P for trend =0.004; 57.64% vs. 48.59%, P for trend <0.001, respectively). Multivariate logistic regression analysis showed a significantly increased risk for knee OA for the SS genotype compared with the AA genotype (OR= 1.984, 95% CI: 1.238-3.181; P =0.004). The adjusted OR for S allele carriage was significantly higher than G allele carriage (OR=1.440, 95% CI: 1.137-1.8231, P=0.002). Moreover, a significant multiplicative interaction was observed between 82G/S polymorphisms with obesity (Pinteraction=0.028). Taking the non-obese 82GG genotype as references, the OR for OA in non-obese SS carriers was 2.537 (95% CI 1.241-5.189, P=0.001). Notably, the OR in obese GS carriers was 2.304 (95% CI: 1.218-4.357, P=0.009) and in obese SS was 3.392 (95% CI: 1.672-6.885, P=0.001). The -374T/A and -429T/C did not show positive interaction with obesity and smoking status. Conclusion: The AGE 82G/S polymorphisms, in interaction with obesity, may determine the susceptibility of OA in Chinese population.