Osteo-sono Assessment Index Research Articles

Cross-sectional survey on the relationship between dairy product intake and bone density among adult women and high school students

Abstract We studied the effects of milk and milk product intake on bone health in Japanese adult women (n=1252; 19-80 years of age), high school girls (n=2651; 15-18 years of age), and high school boys (n = 2110; 15-18 years of age). The data for subjects who performed and did not perform exercise (described herein as with-exercise and no-exercise) were analyzed separately to see whether exercise habits would modify the effects of dairy product intake on bone density. In this study, bone status was evaluated by the Osteo Sono Assessment Index (OSI). The term Z -score was used in the statistical analysis and is defined as the ratio of an individual's OSI to the average OSI of the Japanese at a specific age and sex. Weekly intake of milk and other milk products, as well as exercise habits, was surveyed via a questionnaire. The Z -score of adult women dropped as their weekly milk intake increased, although not enough to be statistically significant ( P Z -score was highest in the subgroup with an intake of 4 to 5 times a week and lowest in the subgroup with an intake of once a week or less ( P Z -score of high school boys rose as their intake frequency of milk increased in both the with-exercise ( P P Z -score of the with-exercise girls rose with increased intake frequency of milk, up to a certain point. The Z -score was highest in the subgroup with a milk intake of 4 to 5 times a week; however, it dropped in the subgroup with a daily intake of milk ( P Z -score of the no-exercise girls did not exhibit any correlation with milk consumption. These results suggest that extensive milk intake reduces the bone density of women, including high school girls, and exercise habits modify the effects of dairy product intake on the bone health of high school students.

Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population

Atherosclerotic cardiovascular disease, osteopenia, and pulmonary dysfunction are the serious health problems, and several experimental studies have suggested that inflammation has a role in them. The present study was conducted to evaluate the usefulness of the plasma CRP is as a common marker for detecting these diseases in the general population in their subclinical stages. In a cross-sectional study, we measured the pulse wave velocity (PWV), quantitative osteo-sono-assessment index (OSI), pulmonary functions, and the plasma level of C-reactive protein (CRP) in 7283 consecutive healthy subjects (age 50 ± 11 years). The PWV was higher and the OSI and pulmonary function parameters were below normal in subjects with an elevated CRP level (≧0.2 mg/dl) than in subjects with a CRP level within the normal range. We divided the subjects into quartiles for each of these parameters and found that the first quartiles represented patients with subclinical states of the aforementioned abnormal conditions. Logistic regression analysis demonstrated that the odds ratios of an elevated CRP level were individually significant in subjects with an elevated CRP level for each abnormality in women and for abnormal PWV and pulmonary dysfunction in men. In conclusion, in addition to being a marker of elevated atherosclerotic cardiovascular risk, elevated plasma CRP seems to be a marker of the early stages of osteopenia and pulmonary dysfunction in healthy subjects.

Significance of intima-media thickness in femoral artery in the determination of calcaneus osteo-sono index but not of lumbar spine bone mass in healthy Japanese people.

The aim of this cross-sectional study was to investigate whether physical activity and local arterial thickening may affect bone metabolism. To analyze the effects of physical activity and atherosclerosis on bone in healthy Japanese people, health-related quality of life (HRQL) and local arterial thickening were assessed by means of the Medical( )Outcomes Study 36-item Short Form (SF-36), and intimal-medial thickness (IMT) in common carotid artery (CA) and femoral artery (FA), respectively. Bone mineral density (BMD) in lumbar spine was measured by dual X-ray absorptiometry and the osteo-sono assessment index (OSI) of the calcaneus by ultrasound. Healthy subjects (106 male and 154 female) were recruited from those who participated in a local health check program at the Osaka City University Hospital. A significant correlation existed between lumbar spine BMD and calcaneus OSI (r=0.551, P<0.0001). Among various scores in SF-36, only physical functioning score correlated weakly but significantly in a positive manner with lumbar spine BMD (rho=0.156, P=0.0147) and calcaneus OSI (rho=0.190, P=0.0024). Lumbar spine BMD correlated negatively with FA IMT (rho=-0.191, P=0.0027) whereas calcaneus OSI with FA IMT (rho=-0.199, P=0.0014). Multiple regression analyses revealed a significant association between FA IMT and calcaneus OSI, whereas lumbar spine BMD did not correlate significantly with FA or CA IMT. When subjects were restricted to female, FA IMT, but not CA IMT, still showed tendency against independent factors negatively associated with calcaneus OSI. Furthermore, lumbar spine BMD, but not calcaneus OSI, was weakly but significantly associated with increased physical functioning score independently. In conclusion, it was suggested that physical activity may affect bone strength in lumbar spine and calcaneus and that FA IMT might be a significant determinant of bone strength in calcaneus, but not in lumbar spine, in healthy Japanese subjects.

Effects of nutrient and food intake on calcaneous bone mass among healthy Japanese women in the predelivery and postpartum periods.

To clarify the dietary factors affecting change in calcaneous bone mass during the predelivery and postpartum periods in healthy Japanese women. The calcaneous bone mass was measured as the osteo sono-assessment index (OSI) using the quantitative ultrasound method in 76 Japanese women who were pregnant between February and June 2000. These women subsequently experienced normal pregnancy and labor and could be followed until the sixth month after delivery at an obstetrics and gynecology clinic center located in metropolitan Tokyo. After the intraindividual changes in the OSI during the follow-up period were determined, the relationship between the OSI or OSI change from gestation to the postpartum period and the estimates of nutrient and food intake obtained using a 140-item semiquantitative food frequency questionnaire (FFQ) were analyzed using stepwise multiple regression analysis. Iron intake in gestation was a significant positive correlate with the percentage change in the OSI between week 36 of gestation and day 5 after delivery (p < 0.001) and that between week 36 of gestation and month 6 after delivery (p < 0.001) (partial regression coefficient of energy-adjusted iron intake, beta = 0.493 mg/day and 0.342 mg/day, respectively). Intake of vitamin D and fruits and vegetables during gestation and/or postpartum was positively associated with the OSI change from week 36 of gestation to the postdelivery stage, whereas the OSI change was inversely related to the intake of carotene, sodium chloride, and meat in the gestation or postpartum period. Sufficient intake of iron, vitamin D, or fruits and vegetables may be important for the preservation of bone mass after delivery.

Preferential reductions of paraarticular trabecular bone component in ultradistal radius and of calcaneus ultrasonography in early-stage rheumatoid arthritis.

Rheumatoid arthritis (RA) is a major cause of secondary osteoporosis and is frequently associated with both paraarticular and generalized osteoporosis. The present study was designed to investigate the preferential sites of reduction of bone mineral density (BMD), in the early stage of RA, with special emphasis on the differential effect of RA on BMD in trabecular and cortical components. The participants (30 RA patients and 26 healthy participants) were all female with disease duration of less than 1 year. BMD in the radius was measured at 4% (ultradistal site) and 20% (midshaft) to the ulnar length proximal to the end of radius by peripheral quantitative computed tomography. BMD in lumbar spine was measured by dual X-ray absorptiometry and the osteo-sono assessment index (OSI) of the calcaneus by ultrasound. RA patients showed lower BMD preferentially in the trabecular component, but not in cortical bone component of the ultradistal radius than age-matched normal controls. Calcaneus OSI was also significantly reduced. The radial midshaft and lumbar spine did not differ significantly between RA patients and normal controls. Trabecular BMD in the ultradistal radius exhibited negative correlations with serum CRP, ESR, and RF, and calcaneus OSI with M-HAQ score. In conclusion, it was suggested that disease activity of RA and impairment of daily physical activity might be a significant determinant of deterioration of bone structure in paraartciular distal radius and calcaneus, respectively, in early-stage RA patients.

Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia.

Although the associations between arterial calcification or advanced atherosclerosis and osteopenia have been well documented, it is not clear whether the one is the result of the other or they coprogress from the early stages through common mechanisms. Thus, we measured pulse wave velocity (PWV), which reflects earlier phase atherosclerosis, and osteo-sono assessment index (OSI), which correlates with bone mineral density, in 7865 Japanese subjects (4183 males and 3682 females, aged 50 +/- 12 yr) and analyzed their association. PWV was determined by the volume rendering method; OSI was measured by the calcaneal quantitative ultrasound method. We evaluated the influence of age, gender, menopausal state, and established atherosclerotic risk factors on this association. In a linear regression analysis, OSI negatively correlated with PWV in both genders, and this association was more prominent in females (r = -0.38, P < 0.01) than in males (r = -0.17, P < 0.01). In females, this relationship was stronger after the menopause. In a multivariate analysis, PWV was significantly associated with OSI independent of age and conventional atherosclerotic risk factors. In females, this association was independent from menopause. These results suggest that common or related mechanisms, which may be accelerated after menopause, control both atherosclerosis and osteoporosis from the early stages.

A longitudinal study of the relationship between osteo sono-assessment index and lifestyle in elderly female in nursing homes

The aim of this study was to investigate the longitudinal effect of mobility and daily activity, in the form of exercise and everyday activities, on the bones of 102 elderly female nursing home residents who had physical disabilities as well as marked postmenopausal bone loss, using calcaneal ultrasound apparatus for bone evaluation.Of the 102 subjects initially measured, 74 (mean age, 83.5±6.55 years; range, 64-99 years) could be measured again approximately one year later. The osteo sono-assessment index (OSI) in this study was determined using an ultrasound bone evaluation device. This device measures the speed of sound (SOS) and transmission index (TI) as ultrasound passes through the calcaneus. The OSI is calculated by computer analysis (OSI=TI×SOS(2)). For mobility, the OSI decreased significantly by an average of 1.8% after 11.8 months in all of the residents who were using a wheelchair (n=41, p<0.01). In contrast, the OSI rose significantly by a mean of 1.9% in the ambulatory group (n=33, p<0.01).The OSI increased significantly in residents who exercised every day, were out of bed for at least seven hours per day, and walked on a regular basis, suggesting that exercise, mainly in the form of walking, may increase the calcaneal OSI.

Increased thickness of the arterial intima-media detected by ultrasonography in patients with rheumatoid arthritis.

To determine whether arterial wall thickening is advanced in rheumatoid arthritis (RA) patients compared with healthy controls by measuring the intima-media thickness (IMT) of the common carotid and femoral arteries, and to evaluate the factors associated with arterial IMT in patients with RA. We studied 138 RA patients and 94 healthy controls (matched for age, sex, and other major risk factors for atherosclerosis). IMT was measured on digitized still images of the common carotid and femoral arteries obtained by high-resolution ultrasonography (10-MHz in-line Sectascanner). Laboratory variables relevant to RA activity were measured by routine methods. The degree of RA progression was assessed by scoring (Larsen method) metacarpophalangeal (MCP) joints on hand radiographs. Activities of daily living were determined by a modified Health Assessment Questionnaire (M-HAQ) score, and physical activity levels were assessed by ultrasound measurement of the calcaneus (expressed as the osteo-sono assessment index [OSI] Z score). Common carotid and femoral artery IMTs were significantly higher (P < 0.05) in RA patients (mean +/- SD 0.641 +/- 0.127 and 0.632 +/- 0.125 mm, respectively) compared with controls (0.576 +/- 0.115 and 0.593 +/- 0.141 mm, respectively). Multiple regression analysis revealed a significant association between RA and the common carotid artery IMT. Moreover, the common carotid artery IMT in RA patients was positively associated with disease duration, the MCP joint Larsen score, and the M-HAQ score, and was negatively associated with the calcaneus OSI Z score. No significant association was found between corticosteroid treatment and common carotid artery IMT. RA patients exhibited greater thickness of the common carotid and femoral arteries than healthy controls. The duration and severity of RA and decreased activities of daily living, but not corticosteroid treatment, were independently associated with the increased arterial wall thickness.

Relationship between nutrient factors and osteo-sono assessment index in calcaneus of young Japanese women

The aim of our study was to investigate the association between nutrient factors and the osteo-sono assessment index (OSI) for calcaneus of young Japanese women. The subjects consisted of 965 young women aged from 18 to 22 years studying at the Department of Food and Nutrition at Nakamura-Gakuen University. The OSI was measured by ultrasonic bone absorptiometry. We found that age, weight, height, exercise, as well as the daily intakes of calcium, phosphorus, protein, energy and sodium were the main factors related to OSI in young women. Positive associations were observed between the OSI and the weight, exercise and daily intakes of calcium, protein and energy, whereas while negative associations were seen between the OSI and the age, height and daily intakes of phosphorus and sodium. In addition, all of these factors were also independently related to the OSI.

Vitamin D insufficiency in Japanese female college students: a preliminary report.

Vitamin D insufficiency, a risk factor for osteoporosis, has been well investigated in elderly women worldwide, but little information has been available for younger women. This study aimed to determine serum 25-hydroxyvitamin D [25(OH)D] levels in Japanese female college students, and to test whether there is an association between 25(OH)D and bone strength. Subjects were 77 Japanese female junior college students aged 19-24 years. Serum 25(OH)D was measured with high performance liquid chromatography. Bone strength of the calcaneus was evaluated using the osteo sono-assessment index (OSI), a combined index reflecting the bone mass, bone architecture, and elasticity, as measured by quantitative ultrasound densitometry (AOS-100, Aloka). The mean 25(OH)D concentration was 34.2 nmol/L (SD +/- 12.1). The proportion of subjects with 25(OH)D less than 30 nmol/L, a cut-off value for vitamin D insufficiency, was 31/77 (40.3%). Simple linear regression analysis showed that there was a significant linear relationship between 25(OH)D and OSI (R2 = 0.098, p = 0.0069). The association held even after adjusting for weight (partial R2 = 0.098, p = 0.0023). Body weight was also a significant predictor of OSI (partial R2 = 0.105, p = 0.0034). These results suggest that vitamin D insufficiency may be prevalent in healthy young women. Moreover, low levels of 25(OH)D in young women may adversely affect bone strength. An additional, newly designed epidemiological study with a sufficient sample size is needed to confirm the present findings.

幼稚園女児のしょう骨骨評価値とその関連因子 母親との類似性を中心に

Osteo sono assessment index (OSI) in the calcaneus in preschool girls aged 3-5 years was assessed using the dry-type ultrasound method. And the relative factors concerning in girls were examined, especially from the standpoint of relationship with their OSI. The findings are as follows.1) The significant difference of mean value for was not observed among three agegroups. Age seems to not affect bone quantity in this age period, 3-5 yr.2) A close association exists between the girl's and their one. The impact of heredity on was seemed to be large in girl aged 3-5.3) Each physically active and mother's OSI was independent factor for OSI.From the above results, the preschool girls whose were low should be consider for increase their bone quantities from the early period both at kindergarten and home.

Bone mineral density and osteo sono assessment index in adolescents

The standard value for bone mineral density in the distal radius (R-BMD) and the osteo sono assessment index OSI) in the os calcaneus for each sex and age in teenagers have not yet been fully reported. The R-BMD and OSI of junior and senior high school students were measured by dual energy X-ray absorptiometry (DEXA) or by a quantitative ultrasound technique. Subjects measured by DEXA included 635 junior and senior high school students (274 males and 361 females, aged 12–17 years). Ultrasound measurements were made for 2878 subjects (1733 males, 1145 females, aged 12–18 years). All subjects filled out questionnaires about their past history, family history, past and present eating habits, sports activities, and for females, the presence of menses, regularity of menses, and so on. The R-BMD in 15- to 17-year-old males was significantly higher than that in females. The R-BMD rate of increase in males was almost linear; the rate of increase in females was significantly highest from ages 12 to 13, after which R-BMD increased gradually. The OSI in 15- to 18-year-old males was significantly higher than that in females. The OSI rate of increase in males was almost linear from ages 12 to 17. The OSI in females, except in 14-year-olds, was roughly equal at each age. The OSI was significantly higher in those who regularly participated in sports, either currently or in the past. It was significantly higher in those who previously or currently consumed milk on a daily basis compared with those who had consumed little or no milk. To prevent osteoporosis, increasing peak bone mass is very important. Adequate calcium intake from dairy products which are rich in calcium and absorbed easily, and exercise in adolescence, are expected to result in increased bone formation and increased OSI.

The available period and kind of exercise for increasing osteo sono assessment index in women

The purpose of this study is to determine the optimum period and kind of exercise which are more effective for increasing the calcaneus osteo sono assessment index (OSI) in adolescent women. The subjects consisted of 600 female students aged from 19 to 21 studying at the Department of Food and Nutrition at Nakamura Gakuen University. The calcaneus OSI was measured by ultrasonic bone absorptiometry. The factors associated with an increased OSI were determined using piecewise linear regression analyses. Experience in performing impact-loading exercise either in junior high school or high school was found to be a significant predictive factor for increased calcaneus OSI after adjusting for age and weight. Regarding other exercise-related factors such as subjective intensity, frequency, hours at a time, and total duration of exercise, a piecewise liner regression analysis showed that a total duration of over 7 yr and a high subjective intensity of the impact-loading exercise during high school and junior high school periods caused a significant increase in the calcaneus OSI. However, the OSI decreased when the subjective intensity of the impact-loading exercise during the high school period was reported to be "very strenuous." Impact-loading exercise in junior high school and high school is important for increasing calcaneus OSI; however, impact-loading exercise in high school with a "very strenuous" subjective intensity was also found to possibly decrease the calcaneus OSI.

An evaluation of a new gel-coupled ultrasound device for the quantitative assessment of bone.

Quantitative ultrasound (QUS) is now being accepted as a tool in the assessment of bone status. Most QUS devices measure broadband ultrasound attenuation (BUA) and speed of sound (SOS). A newly introduced device, the Acoustic Osteo-Screener (AOS-100), measures both SOS and an attenuation related parameter called the transmission index (TI) and provides a derived parameter called osteo sono-assessment index (OSI). The purpose of this study was to examine the reproducibility of this new device, compare the results with the UBA 575+ and evaluate the effect of using two platforms to compensate for different foot sizes on the measured values. 83 subjects aged 21-89 years, who gave informed consent, were recruited. Subjects were assigned to three different groups determined by age and health status. The short-term measurement precision (expressed as root mean square coefficient of variation) of SOS (0.13-0.16%) and TI (1.18-1.96%) was similar to and better than that obtained for the UBA 575+. Significant negative correlations were found between the differences in SOS measured with the two platforms (adaptors to adjust the position of the foot relative to the foot plate) and foot length (p < 0.0001). This implies that small feet are more influenced by the differences of measured location. All QUS parameters measured with the small platform were found to be significantly smaller than those with the large platform (p < 0.0001). The mean percentage differences were 0.6% in SOS, 2.8% in TI and 4.3% in OSI with the large foot platform giving larger value results. Proper use of the platforms resulted in more reproducible SOS and TI. This study demonstrated that the newly developed AOS-100 parameters TI and OSI were highly reproducible. This study also demonstrated that the use of an inappropriate platform can cause discrepancies in QUS readings and poor reproducibility.

J104 某事業所男性従業員の音響的骨評価に関する調査研究(第1報) : 音響的骨評価値と骨折既往に関する関連

J104 某事業所男性従業員の音響的骨評価に関する調査研究(第1報) : 音響的骨評価値と骨折既往に関する関連

J105 某事業所男性従業員の音響的骨評価に関する調査研究(第2報) : 音響的骨評価値と日常生活習慣に関する関連

J105 某事業所男性従業員の音響的骨評価に関する調査研究(第2報) : 音響的骨評価値と日常生活習慣に関する関連

Bone mineral density (BMD) of the calcaneus bone in 72 dialysis patients measured by ultrasonic bone absorptiometry

To determine what factors contribute to and change BMD in dialysis patients. Bone parameters, namely, osteosono-assessment index (calculated by speed of sound and transmission index) were measured at calcaneus bone by ultrasonic bone absorptiometry with an Aloka Acoustic Osteoscreener (Model AOS-100). Seventy two patients were 62. 8 +/- 10.5 years of age (mean +/- SD) (range 36-81) and 70.8% were males; the patients had received dialytic therapy for 52.7 +/- 41.7 months (range 2-205). The effects of sex, age, height, weight, postmenoposal years, dialysis duration, various blood parameters, oral phosphorus binding agent (CaCO3 dosage) and oral vitamin D3 treatment (D3 dosage) on BMD were assessed statistically. BMD in male patients were significantly higher than those in female patients (Mann-Whitney test, p < 0.01). BMD showed significant correlations with age (Spearman's correlation coefficient r = -0.384, p < 0.01), height (r = 0.479, p < 0.00001), postmenoposal years (r = -0.692, p < 0.05), dialysis duration (r = 0.250, p < 0.01), blood Ca level (r = 0.292, p < 0.05) and CaCO3 dosage, postmenoposal years and dialysis duration were the variables that significantly correlated with the BMD (multiple correlation coefficient = 0.646).