Alcohol consumption has been identified as a major risk factor for chronic disease and injury , imposing a considerable burden on sufferers, their families and society. Growing evidence suggests that increased alcohol-induced reactive oxygen species (ROS) and oxidative stress are associated with alcoholic liver disease. Nevertheless, there are no antioxidant additives available for alcohol. Notably, accumulated evidence has confirmed that molecular hydrogen can markedly decrease oxidative stress by selectively scavenging noxius R OS and protect cells and tissues against oxidative damage. Based on these data, it is hypothesized that hydrogen gas may be a favourable additive for alcoholic beverage, with the potential reducing action to ethanol-induced liver injury.