Objective: To observe the clinical effect of Lijin Manipulation combined with Hot Fu Powder in treating periarthritis of shoulder. Methods: Seventy-two patients with periarthritis of shoulder were selected from the orthopaedic outpatient department of the Affiliated Hospital of Shaanxi University of Chinese Medicine, 36 cases in each group. The treatment group was treated with lijin manipulation combined with hot compress powder, while the control group was treated with massage combined with hot compress powder. The course of treatment was 2 weeks. Clinical efficacy, visual analogue scale (VAS) score, Melle score of shoulder function and shoulder motion score were compared before and after treatment, as well as between treatment group and control group in the same group. RESULTS: The clinical efficacy of treatment group was higher than that of control group (P<0.05).After treatment, visual pain score (VAS) and shoulder joint function Melle score in both groups were lower than before treatment (P<0.05), and the decrease in the treatment group was more obvious than that in the control group, the difference was statistically significant (P<0.05).The range of motion of shoulder joint in the treatment group and the control group was higher than before treatment, and the difference was statistically significant (P<0.05). The range of motion in the treatment group was improved more obviously than that in the control group, and the difference was statistically significant (P<0.05).Conclusion: The therapeutic effect of toning tendons manipulation combined with hot compress powder in the treatment of periarthritis of shoulder is obviously better than that of massage combined with hot compress powder. It can better reduce the pain of patients and improve the function and range of motion of shoulder joint, which is worthy of our promotion and application in clinical work.