The output power and voltage of solar photovoltaic power generation are easily affected by climate and load changes, so it is necessary to use DC-DC converter at its output to provide stable output voltage. DC-DC converter is a time-varying nonlinear system. When the output load of the converter varies widely, the output waveform distortion and dynamic response speed of the DC-DC converter will slow down. The essence of sliding mode control is a kind of switch control method, and the DC-DC converter needs the switch of switch tube to realize voltage regulation. In this paper, a sliding mode adaptive control strategy based on orthogonal polynomial function approximation is proposed, and Laguerre polynomial is selected as the basis function of DC-DC transformation system. The output voltage error and its first derivative of the system are taken as the input of the network, and the output of the network is taken as the approximation term of the system uncertainty, and the network weight is updated according to the adaptive law. Through simulation and comparison, the adaptive controller designed in this paper is superior to the ordinary sliding mode controller in reducing chattering, adaptive load change and reducing the influence of system interference.