AbstractSixteen groups of GF/Nano‐Al2O3/PA66 composite samples were prepared by injection molding process and orthogonal experimental design method. The water absorption, hardness, compressive strength, and tribological properties under water conditions were measured. The wear surface morphology and material transfer from mate pair were analyzed by scanning electron microscopy (SEM) and energy spectroscopy (EDS). The results show that the minimum friction coefficient of G25A1 ratio is 0.064, which is 54.3% and 72.2% lower than the two common used sucker rod centralizer materials, respectively; the wear rate of G20A7 is the minimum 7.46 × 10−5 mm3 (N m)−1, 63.6% and 19.9% lower than the two commonly used sucker rod centralizer materials, respectively; the water absorption, hardness and compression strength properties of 16 groups were improved; PA66 matrix composites with the best ratio of 20% GF and 7% Al2O3 were selected in this paper; the wear mechanism of the composite is fatigue wear and a little adhesive wear at moderate additive content, and it is easy to form a transfer film on the mating surface.