The main purpose of this article is to investigate a novel set of (orthogonal) basis functions for treating a class of multi-order fractional pantograph differential equations (MOFPDEs) computationally. These polynomials, denoted bySn(x)and calledspecial polynomials, were first discovered in a study of a certain family of isotropic turbulence fields. They are expressible in terms of the generalized Laguerre polynomials and are related to the Bessel and Srivastava–Singhal polynomials. Unlike the Laguerre polynomials, all coefficients of the special polynomials are positive. We further introduce the fractional order of the special polynomials and use them along with some suitable collocation points in a special matrix technique to treat fractional-order MOFPDEs. Moreover, the convergence analysis of these polynomials is established. Through five example applications, the utility and efficiency of the present matrix approach are demonstrated and comparisons with some existing numerical schemes have been performed in this class.
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