Prescriptions for medications have increased significantly over time. The primary reason for this growth has been the rise in demand for drugs that effectively treat age-related and chronic disorders. Additionally, other variables like health insurance companies and medical ads have had a big impact on the development. Despite the rise in the use of these drugs, researchers claim that children and teenagers are becoming more and more in need of orthodontic treatment. It is evident that individuals who use over-the-counter medications frequently have a variety of consequences from their overuse. Certain pharmaceutical ingredients in these over-the-counter medications may have an impact on remodeling of tissues, the state of tissue homeostasis, and ultimately movement of teeth during orthodontic therapy. In order to concentrate on evaluating and summarizing evidence from previous literatures, as well as examining the effects of regularly used drugs on orthodontic tooth movement, the current review was drafted. Therefore, the goal is to clarify for orthodontists how each drug affects the rate at which teeth shift. This review also discusses some recent pharmacological agents experimented in orthodontics.