Many patients seeking orthodontic treatment are young married women who are in the reproductive stage and sometimes, they become pregnant while undergoing orthodontic treatment. There has always been a dilemma about whether orthodontics and pregnancy could go side by side. It is important for the treating clinician to have a general understanding of the associated medical and dental conditions which may impact the treatment of a pregnant patient. This article provides some updates and key features for the orthodontists regarding the significant medical and dental conditions associated with the management of pregnant patients in an orthodontic clinic. A summarized literature pertaining to this issue and the available studies addressing dental and orthodontics care and treatment in different trimesters of pregnancy has been highlighted in this review.