Previous reports suggest that neonates subjected to maternal narcotic depression (MND) and/or fed by conventional orogastric feeding techniques are at high risk for aspiration pneumonia. We have evaluated this risk by determining LES pressure in 16 neonates of 30-42 weeks gestational age (GA). Neonates were fed 20 cal/oz. commercial similac in consecutive 24 hour time periods by intermittent gastric Ravage, continuous drip gastric gavage, and by continuous drip duodenal gavage. Before termination of each feeding period, LES pressures were determined using a single lumen side opening perfused catheter system currently being investigated at our institution.Narcotic depression was mimicked with 50 mg/kg body weight chloral hydrate given orally and LES pressure measurements were repeated in 90 min. After completion of LES studies at termination of the continuous drip duodenal period, the duodenal side opening feeding catheter was perfused with water at a rate of 1.3 ml/min. and pyloric sphincter (PS) pressures were recorded.The results obtained revealed that LES pressures are not affected by GA, mimicked MND, or the type of feeding technique utilized. Although we have demonstrated a functionally competent PS in the preterm infant as immature as 30 weeks GA, all preterm infants studied exhibited a competent LES and no advantages of nasoduodenal drip feedings are apparent.