Objectives: The aim of this study was to investigate findings of oral abnormalities or changes in these patients, and compare it to healthy control subjects. Materials and Methods: Patients were selected from Thalassemia Center of Pediatric of Al Hussaini Teaching Hospital in Holy-Karbala during the period from March to September 2013. Forty (40) subjects were incorporated in this study. All these patients with age range (4-15) years, (22 males, and 18 females). All these patients were without any other systemic diseases. Results: The prevalence of orofacial complications in β-thalassemia major patients was: prominent maxilla (85%), bad oder (80%), oral ulcers (50%), angular stomatitis (40%), candidal infection (35%), changes in oral mucosa (30%), xerostomia (15%), and the last one was enlargements of salivary glands (zero). Conclusions: Knowing the prevalence of complication can help the dentists to do properly for these patients to solve their problems and improve knowledge of the parents about their children's dental health.