Original Signer Research Articles

New Proxy Signature Scheme over Elliptic Curves using Chaotic Maps Applicable during Pandemic COVID-19

Abstract: Digitalization has attracted the world to collect increasing data. Background: Proxy signature is a digital alternative for signing documents in the absence of the original signer. Methods: In this paper, we have used the mathematical methods and concepts of Chaotic maps (CMs) and elliptic curve cryptography. Results: We have proposed a new proxy signature scheme (PSS). Security of our PSS relies on "elliptic curve discrete logarithm (ECDL) and integer factorization (FAC) problems". It requires only low-complexity computation, which increases efficiency. Conclusion: It is the first PSS in such a security setting and can also be assumed to be secure in the post-quantum cryptographic world. It can be highly used digitally during thePandemic conditions like COVID-19.

Systematic behaviour of 3He/4He in Earth’s continental mantle

Helium isotopes are unrivalled tracers of the origins of melts in the Earth’s convecting mantle but their role in determining melt contributions from the shallower and rigid lithospheric mantle is more ambiguous. We have acquired new 3He/4He data for olivine and pyroxene separates from 47 well-characterised mantle xenoliths from global on- and off-craton settings. When combined with existing data they demonstrate a new systematic relationship between fluid-hosted 3He/4He and major and trace element composition of host minerals and whole rock. We show that a significant proportion (>70 %) of mantle peridotites from continental off-craton settings with depleted major element compositions (e.g., olivine Mg# ≥ 89.5) have 3He/4He in the range of modern-day mid-ocean ridge basalt (MORB) source mantle (7–9 Ra) and we propose that they represent underplated melt residues, which initially formed in the convecting upper mantle. Furthermore, we observe that off-craton mantle xenoliths with signatures often attributed to enrichment by melts or fluids from ‘ancient’ subducted oceanic lithosphere have lower 3He/4He (<7 Ra). Modest correlations between 3He/4He and whole rock incompatible trace element signatures commonly used as proxies for metasomatism by small-fraction carbonatite and silicate melts or C-O-H fluids characterise lithospheric mantle with 3He/4He ranging from 5 to 8 Ra.Using a numerical model that integrates temperature-dependent melt extraction from the upper mantle with in-situ radiogenic ingrowth of 4He in the continental mantle we show that the initial 3He/4He of continental lithosphere mantle has decreased over time. This is consistent with previous observations demonstrating that ancient (2.5–3.5 Ga) cratonic mantle has a depleted mineral chemistry (e.g., olivine Mg# = 91–94) and low 3He/4He (0.5–6.7 Ra), while continental off-craton mantle (<2.5 Ga) is more fertile (olivine Mg# = 88–92) and has less radiogenic 3He/4He (4–8.8 Ra). This relationship defines a ‘global lithospheric mantle array’ for intraplate peridotites on plots of 3He/4He vs olivine Mg#. Peridotites influenced by past and present subduction fluids, including those that contain amphibole, plot off this array. Our findings have broad implications for the 3He/4He signatures observed in continental magmas. Many of Earth’s deepest melts, i.e. proto-kimberlites, are characterised by relatively low 3He/4He. We attribute this to assimilation and incorporation of low 3He/4He cratonic mantle material during ascent of carbonate-rich melts through thick lithosphere, which overprints the original signatures. Moreover, our findings suggests that the lithospheric mantle acts as a long-term reservoir for other fluid-hosted volatiles (e.g., CO2, CH4, H2O), and in some cases able to sequester these over billion-year timescales until physio-chemical perturbation (e.g., during major rifting or heating events).

Deep Learning Based Offline Handwritten Signature Recognition

In our digitalized world, the need for reliable authentication methods is steadily increasing. Biometric authentication methods are divided into two main categories: physiological and behavioral. While physiological biometrics include features such as face, iris, and fingerprint, behavioral biometrics encompass dynamics such as gait, speech, and signature. Most of these methods require specialized equipment, whereas signatures can be easily obtained without additional tools, making them ideal for verifying the legality of documents. Although manual signature recognition is effective, it is resource-intensive, slow, and susceptible to errors. With advancements in technology, the need to automate the signature recognition process to enhance accuracy and efficiency has become increasingly important. Based on this need, in this study, five different DL techniques (GoogLeNet, MobileNet-V3 Large, Inception-V3, ResNet50 and EfficientNet-B0) are used to classify signature images with detailed analyses. DL methods have outperformed traditional techniques by leveraging the power of CNNs to automatically learn and extract complex features from signature data. The dataset used consists of a total of 12,600 images belonging to 420 individuals, each contributing 30 original signatures. The dataset is divided into training, validation, and test sets in different proportions to analyze classification performance. The pre-trained DL models were fine-tuned to optimize their parameters for the signature dataset. The results demonstrate that DL models achieve high accuracy in signature classification, with the GoogLeNet and Inception-V3 models reaching an accuracy of 98.77% at a 20% test rate. The study also highlights the impact of different test rates on model performance.

Rare-metal halos of lithium pegmatite at the Wolfsberg deposit, Austria, and their implications for exploration

The Austroalpine Unit Pegmatite Province (AUPP) in the eastern European Alps hosts abundant Permian-aged, variably rare-metal-enriched pegmatite bodies. However, only a small number containing spodumene [LiAlSi2O6] have been discovered. Here, we characterize three drill cores from the AUPP’s largest spodumene pegmatite resource, the Wolfsberg deposit (Austria), to determine the extent of rare-metal halo formation within different host rock types generated by pegmatite-derived fluids and their applicability to spodumene pegmatite exploration. The halos in both mica schist and amphibolite host rocks, as quantified via whole-rock mass-balance calculations, are characterized by enrichments in Li, Cs, Sn, Rb and Tl, amongst others, elements which were highly mobile during initial interactions between pegmatite-derived fluids and host rocks. The concentrations of these elements within the halos can be several times that present in unaltered host rock. They are most enriched in altered host rock interbedded or at the contacts with pegmatite, and decrease with distance from pegmatite to a distance of at least 4 m in mica schist and <3 m in amphibolite. Lithium, and in mica schist, Cs, have the most consistent and furthest extending halos, with respective concentrations of >590 ppm and >40 ppm in mica schist, and >390 ppm Li in amphibolite indicating proximity to spodumene pegmatite. An ID-TIMS U-Pb titanite age of ca. 103 Ma derived from a rare-metal-enriched amphibolite within the alteration halo reflects recrystallization of the Permian protolith during the Cretaceous Alpine orogeny and indicates preservation of the original pegmatite signature through eclogite-facies metamorphism. Recognition of rare-metal halos surrounding pegmatite at Wolfsberg serves as a potential geochemical exploration tool for spodumene pegmatite within the AUPP and may be applicable to other regions.

Modulating Helix-Preference of an Axially-Twisted Molecular Scaffold Through Diastereomeric Salt Formation with Tartaric Acid Stereoisomers.

Herein, we designed a chiral, axially-twisted molecular scaffold (ATMS) using pyridine-2,6-dicarboxamide (PDC) unit as pivot, chiral trans-cyclohexanediamine (CHDA) residues as linkers, and pyrene residues as fluorescent reporters. R,R-ATMS exclusively adopted M-helicity and produced differential response in UV-vis, fluorescence, and NMR upon addition of tartaric acid (TA) stereoisomers allowing naked-eye detection and enantiomeric content determination. Circular dichroism (CD) profile of R,R-ATMS underwent unique changes during titration with TA stereoisomers - while loss of CD signal at 345 nm was observed with equimolar D-TA and meso-TA, inversion was seen with equimolar L-TA. Temperature increase weakened these interactions to partially recover the original CD signature of R,R-ATMS. 2D NMR studies also indicated the significant structural changes in R,R-ATMS in the solution state upon addition of L-TA. Single crystal X-ray diffraction (SCXRD) studies on the crystals of the R,R-ATMS⊃D-TA salt revealed the interacting partners stacked in arrays and ATMS molecules stabilized by π-π stacking between its PDC and pyrene residues. Contrastingly, tightly-packed supramolecular cages comprised of four molecules each of R,R-ATMS and L-TA were seen in R,R-ATMS⊃L-TA salt, and the ATMS molecules contorted to achieve CH-π interactions between its pyrene residues. These results may have implications in modulating the helicity of topologically-similar larger biomolecules.

Reservoir heterogeneities due to diagenesis in Jurassic Samana Suk Formation Kahi section Nizampur Basin North West Himalayas Pakistan

The porosity and permeability determine the reservoir quality of sedimentary rocks, which is fundamentally influenced by both depositional and diagenetic processes. The Jurassic carbonates are targeted in many regions for oil and gas exploration. The current study is carried out to elaborate on the diagenetic alterations and their effect on reservoir properties. A thick outcrop of the Jurassic Samana Suk Formation is studied in the Kahi section of Nizampur Basin Northwest Himalayas, Pakistan, to study and relate the trend of lithological variations and depositional settings. Field investigation revealed that the Samana Suk Formation is extensively distributed in the area and primarily made up of interbedded limestone and dolomite units. The original unaltered limestone has a thick-bedded and oolitic to bioclastic nature. Different types of dolomites have been recognized based on colour contrast and sedimentary features. Moreover, saddle dolomite cement, calcite cementation, and mechanical and chemical compaction have also been observed. The petrographic studies show different types of diagenetic alterations that affected the Samana Suk Formation, including micritization, bioturbation, mechanical and chemical compaction in the form of fractures and stylolites, various calcite cementation, which includes the various cement types that range from isopachous, blocky, granular equant, fibrous, and dog tooth cementation, along with dissolution that occurred in different diagenetic realms. Pyritization was rarely observed. Moreover, different phases of dolomites were identified, ranging in size and shape, i.e., finely crystalline to coarse crystalline and planar euhedral to non-planar anhedral. The stable oxygen isotope values of these dolomites show depletion from original marine signatures and suggest burial-related fault-controlled dolomitization events. Overall, diagenetic processes like dissolution, fracturing and dolomitization increased the reservoir potential. On the contrary, the overburden and cement precipitation result in a decrease in the reservoir properties.

What is the source of magnesium in hydrothermal dolomites? New insights from coupling δ26Mg - ∆47 isotopes

The occurrence of fault-controlled hydrothermal dolomitization (HTD) is ubiquitous across stratigraphic records and has been extensively studied due to its association with economic resources. The origin of HTD is often evaluated by combining carbonate geochemistry, fluid inclusion thermometry and reactive transport modelling. However, multiple diagenetic overprinting events can obscure original geochemical signatures. Here, we demonstrate the applicability of two combined isotope systems, magnesium and carbonate clumped isotopes (δ26Mg - ∆47), to trace the source of fluid and magnesium in basin-scale HTD from the Western Canadian Sedimentary Basin (WCSB) and Southern China. Extensive studies in these regions, providing tectono-stratigraphic information and dolomitization models, furnish a robust scenario to evaluate the new isotopic data. Our findings reveal that while the previous geochemical data (δ18Ofluid and 87Sr/86Sr) are partly compatible with dolomitization from seawater, the elevated δ26Mg and δ18Ofluid values (up to -0.3‰ and +11‰, respectively) and the high temperatures (up to 320 °C) are not consistent with dolomitization from seawater alone. Considering this, the uniform mean δ26Mg values of silicate rocks (-0.25‰) and the occurrence of basement-rooted faults in the study areas, the hypothesis from prior work that dolomitization was initially driven by seawater that progressively mixed with crustal fluids sourced from underlying basement rocks, was supported. As the δ26Mg values may reflect the isotopic signature of the fluid and the leached host rocks, when combined with ∆47-derived temperatures, it results in an effective tracer of fluid and Mg sources during dolomitization in tectonically complex basins that are otherwise challenging to unravel. A comparison of our results paints a global picture of isotopic imprints in hydrothermal dolomite and further demonstrate the ability of Mg isotopes to differentiate between dolomitization from seawater versus evaporated brines and also through Mg-rich crustal fluids.

Comparing Traditional and Digital Methods for Detecting Forged Signatures in Forensic Analysis

Abstract: Signatures are considered proofs for the validation of documents. Forgery of the signature is seen in almost all documents, ranging from bank checks, property papers, legal documents, and so on. The analysis of the signature can be a challenging task for forensic experts as fewer alphabets are used, so finding characteristics is difficult. In this research paper, we have discussed two ways of analyzing forged signatures: traditional and digital methods (Matlab and Python software). Traditional method: manual analysis of forged signatures with the help of a stereomicroscope and magnifying glass; digital method: using Matlab and Python software for analysis. In Matlab software, a curve fitting function is used in which the deviation of the graph is analyzed for both original and forged signatures. In Python software, two samples are added, one of which is the original signature and the other is the questioned sample. For analysis, 400 samples of signatures were used: 200 samples of the original signature and 200 samples of the questioned signature. The main aim of the paper is to find an easy and less time-consuming method for the analysis of the forged signature. The digital method has shown an accuracy of 95%. So it can be said that the digital method requires less time than the traditional method, and the accuracy and efficiency are almost the same.

Signature Fraud Detection Using Deep Learning

The use of signatures for personal identification and verification is quite common. Signatures are validated for many documents such as Bank cheques and legal transactions. The necessity for effective automated solutions for signature verification has grown as signatures are now a prerequisite for both authorization and authentication in legal activities. Two images—the original signature and the test signature—are used as input in this process. To determine whether the signature is fake or not, the characteristics that were extracted are compared, and the difference in error values between them is examined. The growing digital landscape has increased the need for robust and efficient fraud detection systems. This project presents a unique approach to detecting signature fraud using deep learning techniques, specifically employing Siamese Neural Networks, implemented in Python. With a dataset comprising 2149 signature images, encompassing both genuine and fraudulent samples from Dutch users, our model demonstrates remarkable accuracy. The Siamese Neural Network architecture excels in signature verification tasks by learning to distinguish between genuine and fraudulent signatures through contrastive learning. The key achievement of this project is the exceptional accuracy levels attained during the training and validation phases. The model's training accuracy stands at an impressive 98.00%, while the validation accuracy reaches an astonishing 99.00%. These high accuracy rates are a testament to the effectiveness of Siamese Neural Networks in signature fraud detection. In a world where the security of digital signatures is paramount, this project showcases the power of deep learning and Siamese Neural Networks in safeguarding against fraudulent activities. The model's success in accurately distinguishing between authentic and forged signatures offers promising potential for enhancing security measures in various domains, including finance, legal, and document management.

Origin and microbial degradation of thermogenic hydrocarbons within the sandy gas hydrate reservoirs in the Qiongdongnan Basin, northern South China Sea

Large-scale natural gas hydrate accumulations (generally over one billion cubic meters of natural gas) in coarse-grained marine sediments are the most valuable types for commercial exploration and exploitation. The formation of such a gas hydrate deposit generally requires a sufficient natural gas supply such as deeply buried thermogenic gas source. However, the worldwide discovered thermogenic gas hydrate deposits are rare, leaving relatively a poor understanding of their formation and evolution. Based on the geochemical and microbial analyses of eleven hydrate-related gas and five sediment samples from the thermogenic gas hydrate deposits in the Qiongdongnan Basin in northern South China Sea, we systematically investigated the origin and evolution of thermogenic hydrocarbons within sandy gas hydrate reservoirs. Results show that natural gas within high saturated gas hydrate-filled sandy sediments is predominately of thermogenic (the proportion is 57.1–70.5%), characterized by “dry gas” (99.38–99.7% C1, 0.26–0.47% C2 and <0.5% C3+), relatively lower C1/(C2+C3) ratio (187–376), and heavier δ13C–C1 values (−55.0 to −31.3‰). In addition, typical biomarkers (including the alkanes, tricyclic terpanes, hopanes and steranes) generated from mature source rocks were detected in the hydrate-filled fine sand reservoir, as well as the biomarker indicators (including the unresolved complex mixtures (UCMs) hump and the 25-norhopane homologous series) for severe hydrocarbon biodegradation. Furthermore, large amounts of hydrocarbon degrading bacteria (50.5% of bacteria) and methanogenic archaea (34.3% of archaea) were detected within hydrate-filled sandy sediment. Our results indicated that the deeply buried thermogenic source can indeed provide sufficient gas supply for the formation of a large-scale gas hydrate deposit, but thermogenic liquid hydrocarbons within gas hydrate reservoirs are very susceptible to be degraded and consumed by hydrocarbon degrading bacteria. In addition, we also found that the clay components of argillaceous gas hydrate reservoirs can adsorb and store large amounts of in situ immature organic matter, which can significantly obscure or cover up the original geochemical signatures of thermogenic hydrocarbons therein. These findings suggest that the relative contribution of deeply buried thermogenic source for gas hydrate accumulation worldwide may be underestimated, because we have previously ignored the fact that thermogenic hydrocarbons within gas hydrate reservoirs would be significantly consumed by hydrocarbon degrading microbes or diluted by in situ immature sedimentary organic matter. Our findings are highly significant for the evaluation and exploration of thermogenic gas hydrate accumulations worldwide.

The Newton-Stefan-Boltzmann-Planck Code. The Solar Microwave Background Formation on the Blackbody Sphere at the Distance R = 140 AU

In this model the Solar System presented to observers on the planet Earth the elegant gift: the Solar Microwave Background (SMB) formed on the Blackbody Sphere at the distance R = 140 AU. The thermalization of the Hydrogen wall at this distance was described using the Stefan-Boltzmann law where the temperature of the blackbody at the distance R = 1 AU is T = 393.6 K. Newton’s cooling law described the cooling of this blackbody surface temperature with the cooling constant κ = 1.139 × 10−4 s−1 calculated from data of the small planet Pluto (average distance R = 39.5 AU and the temperature T = 44 K). The SMB monopole temperature T = 2.7255 K was fitted for the distance R = 140 AU with the temperature of the surrounding TENV = 2.5887 K. The first important difference with the model of the cosmic microwave background (CMB) is the magnitude and direction of Newton’s dipole v = (200 + 141) kms−1 towards the galactic coordinates (l, b) = (84°, −48°) while the magnitude and the direction of the Doppler’s dipole of CMB is v = 368 kms−1 towards (l, b) = (264°, 48°). This new model enables to estimate the rotation velocity of the Sun in the Milky Way Galaxy, the motion of the Milky Way Galaxy through the Universe, and the Harress-Sagnac color excess: v = 200 + 141 + 27 = 368 kms−1. The total motion of the Milky Way Galaxy through the Universe can be estimated with the knowledge of the Cold Spot direction in the SMB and the motion towards the Galactic South Pole. In this model, the Milky Way Galaxy can avoid collision with the Andromeda Galaxy. The observed quadrupole, octopole, and hemisphere structure of the SMB can be explained as the local motion of the Sun and the Solar axis inclination towards the ecliptic–the Axis of evil should be renamed as the Solar axis bringing to us a good opportunity to discover differences between the SMB and the CMB. The first peak in the power spectrum of the SMB at the distance R = 140 AU is observed from the COBE, WMAP, and PLANCK satellites rotating around the Sun at the distance R = (2×1) AU under the angle θ = 0.818°. The power spectrum observed from the planets Mercury and Jupiter will have different positions of the first and higher peaks. The original Solar signature should be visible as the moving shadows of the Sunspots on the Blackbody Sphere. There were proposed several experiments on how to distinguish between the SMB and the CMB.

Unravelling the genesis and depositional setting of Neoproterozoic banded iron formation from central Eastern Desert, Egypt

The Neoproterozoic banded iron formations (BIFs) are widely occurred in the Egyptian Eastern Desert. This study integrates field observations, petrographic studies, geochemical data, and lead isotopes to construct the genesis and depositional environment of Wadi El-Mis hama BIF deposits. The iron layers, primarily of oxide facies within a volcano-sedimentary sequence, comprise magnetite-rich beds alternating with jaspilite or silicate laminae. The studied BIFs exhibit a dominant composition of SiO2 and Fe2O3t with relatively low contents of TiO2 and Al2O3. The positive correlation of REEs (La, Sm, Yb) with Zr and low concentrations of HFSEs (Ta, Nb, Th, Hf) indicate a primary formation mechanism of chemical precipitation, maintaining original geochemical signatures. Geochemical patterns show depletion in LREEs, enrichment in HREEs (La/YbPAAS = 0.08–0.12), and positive La anomalies (La/LaPAAS = 1.15–8.57), consistent with seawater influence. Additionally, various geochemical discrimination diagrams supported by elevated super-chondritic Y/Ho values (29.6–38.7), weak positive Eu anomalies, and low contents of transition metals (Cu and Zn), point to the interaction of low-temperature (&amp;lt;200°C) hydrothermal fluids (bearing Fe and Si) with seawater during the deposition of the BIFs. The lack of significant negative Ce anomalies along with low Ni/Co, U/Th, and Cu/Zn ratios, imply that the iron mineralization was precipitated from dysoxic to oxic conditions. The geochemical and Pb isotopic data suggest that the iron deposits formed in an extensional geodynamic setting (intra-oceanic arc basin environment) due to the subduction of the Mozambique Plate, with signatures closely matching other Precambrian Algoma-type BIFs.

Electronic communication between employer and employee during martial law

The article considers the need for flexibility and adaptability in managing labor relations during martial law. An important step taken by the legislator on the way of organizing personnel paperwork between the employer and the employee is the legislative consolidation of the norms that give employers the opportunity to independently determine these processes, while ensuring reliable accounting of the work done and labor costs. Under martial law in Ukraine, it is allowed to use electronic exchange of documents. This means that the employer and the employee can agree on alternative methods of creating, sending and storing official documents, such as orders or notifications. Such methods may include the use of electronic communications that are chosen by agreement between the employer and the employee. These measures are intended to help ensure the continued existence of existing labor relations and the preservation of important documentation during martial law. The introduction of such changes has become important, since martial law can complicate the usual communication procedures. These changes also help to avoid misunderstandings and conflicts. However, if the employer and the employee have not agreed on the electronic exchange of documents, then official documents must be submitted in paper form with the original signature of the author of the document. This is important because sending an application electronically does not allow the other party to verify the authenticity of the applicant’s will. It is also possible to use a phone to exchange information, although this may be less effective for some types of documents. In any case, it is important that both sides of the labor legal relationship - both the employee and the employer are aware of what methods of communication will be used, and agree with them. Under martial law, among other things, additional procedures may be introduced to ensure the effective exchange of documents. From the analysis of existing judicial practice, it is seen that in all of these methods and methods of communication, the main thing is still the fact that the employer and the employee agree between themselves on the appropriate method of exchanging documents, since the absence of a confirmed agreement will affect both the rights and obligations of the employer and the rights and obligations of the employee.

A multi-party verifiable quantum proxy signature scheme based on quantum teleportation

With the development of science and technology and the appearance of various special conditions that cause signers to be unable to sign, proxy signature is gradually becoming a hot spot in cryptography research. This paper combines proxy signature, quantum teleportation, and multi-party verification and proposes a multi-party verifiable quantum proxy signature scheme based on quantum teleportation. This scheme has the following characteristics: The authentication method based on the Hash function can effectively solve the problem of identity identification among members; in order for the proxy signer to be able to verify the correctness of the proxy authorization, a form of proxy signature authorization that concatenates the identity information of the original signer is used. The security analysis shows that our scheme is unforgeable and undeniable and can resist intercept-resend attacks and cheating attacks.

A structure-preserving linearly homomorphic signature scheme with designated combiner.

Linearly homomorphic signature (LHS) allows the acquisition of a new legal signature using the homomorphic operation of the original signatures. However, the public composability of LHS also prevents it from being used in some scenarios where the combiner needs to be designated. The LZZ22 scheme designates a combiner and preserves the signature structure by having the signer and the designated combiner share a secret. However, LZZ22 is not secure enough because the secret is constant. Here, we first prove that there is a polynomial time adversary that can crack the secret in LZZ22 through multiple signature queries. Then, we propose a new scheme, which realizes all the functions of LZZ22 and fixes the security problem by changing the secret with the message. The proposed scheme is shown to be secure against existential forgery on adaptively chosen subspace attacks under the random oracle model. Finally, we detail how to apply our scheme to the proxy signature and perform it on a personal computer, and the results show that our scheme is efficient.

Acid-Induced Gelation of Carboxymethylcellulose Solutions.

The present work offers a comprehensive description of the acid-induced gelation of carboxymethylcellulose (CMC), a water-soluble derivative of cellulose broadly used in numerous applications ranging from food packaging to biomedical engineering. Linear viscoelastic properties measured at various pH and CMC contents allow us to build a sol-gel phase diagram and show that CMC gels exhibit broad power-law viscoelastic spectra that can be rescaled onto a master curve following a time-composition superposition principle. These results demonstrate the microstructural self-similarity of CMC gels and inspire a mean-field model based on hydrophobic interchain association that accounts for the sol-gel boundary over the entire range of CMC content under study. Neutron scattering experiments further confirm this picture and suggest that CMC gels comprise a fibrous network cross-linked by aggregates. Finally, low-field NMR measurements offer an original signature of acid-induced gelation from a solvent perspective. Altogether, these results open avenues for the precise manipulation and control of CMC-based hydrogels.

Comparative Study of Mendol as an Indonesian Traditional Side Dish in Food Tourism

Efforts to stimulate economic growth, especially after the impact of the pandemic, are currently being undertaken worldwide. The tourism sector, a major economic driver, is transforming strategically. One promising strategy involves promoting traditional cuisine to enhance culinary tourism. Indonesian traditional dishes are an essential aspect of cultural heritage, and mendol is one of Indonesia’s original signature dishes, particularly in Malang, East Java. This research aims to understand the highly sought-after combination of mendol dishes along with traditional Indonesian cuisine through Twitter data analysis. The study employs the Apriori algorithm to analyze the Twitter data’s frequent item sets and association rules. The research findings reveal that mendol is a highly favored dish among Indonesian Twitter users, with Rawon, Nasi Jagung, and Pecel also receiving significant attention. The uniqueness of this research lies in the application of the Apriori theorem method to determine the most valuable culinary combinations within the framework of local culinary co-creation. This research provides insights that can be implemented to optimize culinary presentation, shape a distinctive image of local cuisine, and enhance the appeal of culinary tourism. Ultimately, this contribution is expected to positively impact economic growth.

Design of Online Certificate Legalisation Information System at Indramayu State Polytechnic

An information system is a collection of interconnected elements that form a unity in integrating data, processing, storing and distributing information. Legalization is an attestation process by providing an original stamp and signature from the authorities on a photocopy of a diploma or grade transcript as proof that the photocopy matches the original diploma or grade transcript. The legalization process at the Indramayu State Polytechnic which is currently running is still done manually. This mechanism requires alumni who wish to legalize their diplomas or transcripts to come directly to campus. The legalization service system that is currently running at the Indramayu State Polytechnic is considered to be less effective because it takes a long time for alumni to process the application. Based on the problems above, the researcher aims to design a website-based information system for legalizing diplomas and transcripts. The legalization system is designed to focus on the needs of alumni and those from the academic department who are responsible for ratifying documents for legalizing diplomas and transcripts. The result of this research is a website platform for submitting online legalization requests which can help the academic section of the Indramayu State Polytechnic in managing legalization applications and make it easier for alumni to submit legalization applications.

Exploring uranium isotopes in shark teeth as a paleo-redox proxy

The uranium isotope composition (δ238U) of seawater is a powerful proxy for the extent of marine anoxia. For paleoredox reconstructions, carbonates are the most popular U isotope archive, but they have recently come under increased scrutiny as their δ238U values are subject to diagenetic alteration after deposition. Therefore, there is a need to investigate other archives that may record and preserve the original seawater δ238U signal. In this study, we explore whether shark teeth provide such an archive. Shark teeth enameloid consisting of crystalline fluorapatite is more resistant to post-depositional alteration and less sensitive to isotopic exchange than marine carbonates due to the lower solubility of the crystalline fluorapatite. Since U is readily incorporated into phosphate, shark teeth could incorporate and preserve the original δ238U signature of seawater.To assess whether U isotopes in shark teeth can record seawater signatures, we measured the U isotopes (both δ238U and δ234Usec) in 39 fossil shark teeth from various locations, including Banks Island (Arctic), the Gulf of Mexico (GOM), and Pisco Basin (Peru), and ranging in age from modern to Cretaceous. Our results show that U concentrations are negligible in modern shark teeth (<1 ppb) but elevated in fossil samples (up to several hundred ppm), indicating that U is incorporated into shark teeth postmortem during burial. The δ238U values range from −0.72 to +0.57 ‰, and the δ234U values from −162.1 to +969.7 ‰. The data indicate that (i) diagenetic overprinting of seawater U isotope ratios is common among shark teeth, and (ii) δ238U data are influenced by local depositional environments. Nonetheless, the U isotope variations observed in shark teeth are comparable to those seen in marine carbonates, indicating that the samples with less diagenetic alterations might offer useful insight into the past extent of ocean anoxia.

The FLT3-like Gene Expression Signature Predicts Response to Quizartinib in Wild-Type FLT3 Acute Myeloid Leukemia: An Analysis of the Pethema Quiwi Trial

Background The identification of predictive biomarkers is crucial for guiding treatment decisions in acute myeloid leukemia (AML). Previously, we identified a FLT3-like gene expression signature in FLT3 wild-type AML patients, which clustered a variable proportion of FLT3 wild-type patients with FLT3-ITD and TKD mutated patients. The QUIWI trial was a randomized, placebo-controlled, phase II study preliminary showing a significant increase in overall survival (OS) in wild-type FLT3 AML patients treated with the FLT3 inhibitor quizartinib (Quiza) plus standard chemotherapy. This preplanned correlative study was designed to assess the value of the FLT3-like signature to predict responses to Quiza. Methods We performed RNA sequencing (RNAseq) analysis on a subset of patients from the clinical trial. RNA was extracted using standard methods, followed by assessment of nucleic acid integrity (TapeStation) and quantification (Qubit). Total mRNA sequencing was performed using polyA RNAseq with TruSeq technology. A total of 206 adequate samples from bone marrow and peripheral blood were sequenced (161 from FLT3-ITD negative enrolled in QUIWI; and 55 from FLT3-ITD positive patients who were screen failure of the QUIWI trial by this reason). The sequences were aligned to the GRCh37 reference genome using the Hisat algorithm. Gene expression quantification was performed using the Bioconductor workflow, and gene expression estimates (FPKM) were obtained. The gene expression estimates were log2 normalized. Finally, those genes mapping to the original FLT3-like signature (595 genes) were selected for downstream analysis. Clustering was based on the hierarchical method, using standard euclidean distance metrics. OS was defined as time from start of screening to death. Event-free survival (EFS) was defined as time from randomization to failure to achieve CR/CRi after 1 or 2 cycles, death in CR/CRi, or relapse (whichever occurred the first). Relapse-free survival was defined as time from randomization to disease relapse or death by any cause. Results Among the total 206 patients, a cluster of 54.37% (N=112) was enriched in FLT3-mutant cases (71.11% of cases, Figure 1A). This subgroup comprised 49.67% of wild-type FLT3 cases (N=80), hereafter FLT3-like patients. In the group of not FLT3-like patients, no differences were identified between the placebo and Quiza group in the total number of deaths (Fisher's p-value, 0.63), EFS (cox p-value, 0.83; HR 1.07 [0.56-2.06]), RFS (cox p-value 0.76; HR 0.88 [0.38-2.01]) and OS (cox p-value, 0.62; HR 1.22 [0.55-2.67]). Among FLT3-like patients, significant differences were identified in the total number of deaths (Fisher's p-value, 0.004), EFS (cox p-value, 0.009; HR 0.45 [0.25-0.82], RFS (cox p-value 0.01, HR 0.37 [0.18-0.79]) and OS (cox p-value 0.01, HR, 0.41 [0.20-0.84]) ( Figure 1B). No statistically significant association was observed between the FLT3-like pattern and the ELN-17 classification: 30.4% were low risk, 40.5% intermediate risk, 29.1% high risk. Conclusion The FLT3-like gene expression signature successfully identified a subset of patients who derived the most benefit from Quiz, while patients without the FLT3-like signature did not demonstrate a benefit compared with placebo. These findings support the use of the FLT3-like signature as a potential biomarker to identify those wild-type FLT3 AML patients who may benefit from Quiz, providing a valuable insight for personalized treatment in AML.