The COVID‐19 pandemic shut down laboratories across the nation for many months. Scientists at all academic levels had to think creatively and design, if possible, engaging remote projects for their students. Based on journal reviews from renowned educators, we decided to perform a systematic literature review of publicly available material to summarize information about SARS‐CoV‐2, the virus responsible for the current pandemic, which has affected 87.5 million people with 1.89 million deaths worldwide (as of Jan 7, 2021).Using the PubMed Central (PMC) advanced search builder, we were able to narrow the initial 93,999 results for COVID‐19 related articles published in the past year (Nov 2019 – Nov 2020) to 543 publications that were related to SARS‐CoV‐2, spike protein structure and its receptor. Relevant articles in peer‐reviewed journals were identified from this list and comprehensive analysis of ~40 research articles were conducted and summarized. This compilation was used in a case‐study model to narrate a story simplifying the complexities of COVID‐19 infection while providing detailed qualitative information, which would otherwise be difficult and sensitive to discuss. This model for summer research enhanced students’ critical thinking skills necessary to ponder questions related to COVID‐19 in preparation to enter the healthcare profession.This directed patient case study was designed by using data from real life situations and applying it to fictitious patients to maintain anonymity. The storyline follows three individuals (85‐year‐old male, 80‐year‐old female, and a 50‐year‐old male) and their families during the 2019–2020 coronavirus outbreak in the United States. The timeline of patients’ infections, testing, interventions, and outcomes are discussed. Additional sections on COVID‐19 gender disparities and atypical symptoms are also provided.Students in upper‐level biology and health science courses, such as physiology and pathophysiology, will research the symptoms, susceptibility, mechanism of action, progression of the infection, opportunistic infections, extrapulmonary complications and treatments. The case concludes with an assignment to discuss the most current information available regarding the progress made in designing novel treatments.This project was presented at the Natural Science Summer Research program and parts of it will be introduced to students in local high schools as part of Benedictine University's (BenU) outreach activity. We are in the process of submitting a detailed version of this case to the National Center for Case Study Teaching in Science. Working on the various aspects of the case, including instructor notes, answer key and presentations, honed the critical analysis and communication skills of the research students. Despite various tragedies and challenges, the pandemic offered the unique opportunity to identify novel topics and techniques to circumvent original project goals and traditional undergraduate research methods, as well as provide freedom for innovation that can ultimately benefit the academic community.