Original Article Research Articles

Fixed Effects and Post-Treatment Bias in Legacy Studies

Pepinsky, Goodman, and Ziller (2024, American Political Science Review, PGZ) reassess a recent study on the long-term consequences of concentration camps in Germany. The authors conclude that accounting for contemporary (i.e., post-treatment) state heterogeneity in the models provides unbiased estimates of the effects of camps on current-day outgroup intolerance. In this note, we show that PGZ’s empirical strategy rests on (a) a mischaracterization of what regional fixed effects capture and (b) two unrealistic assumptions that can be avoided with pre-treatment state fixed effects. We further demonstrate that results from the original article remain substantively the same when we incorporate regional fixed effects correctly. Finally, simulations reveal that camp proximity consistently outperforms spatially correlated noise in this specific study. The note contributes to the growing literature on legacy studies by advancing the discussion about the correct modeling choices in this challenging field.

Effects of Tenofovir Disoproxil Fumarate on Bone Quality beyond Bone Density-A Scoping Review of the Literature.

Tenofovir disoproxil fumarate (TDF) is a widely used pharmacological agent for the treatment of human immunodeficiency virus infection. While prolonged exposure to TDF has been associated with a decrease in bone mineral density (BMD) and increased fracture risk, limited discussion exists on its effects on various aspects of bone quality. This scoping review aims to provide a comprehensive overview of the impact of TDF on bone quality beyond BMD. A literature search was conducted using the PubMed and Scopus databases to identify studies investigating the effects of TDF on bone quality. Original research articles written in English, irrespective of study type or publication year, were included in the review. Seven articles met the inclusion criteria. Findings indicate that prolonged exposure to TDF adversely affects bone microarchitecture and strength, impeding fracture healing and skeletal microdamage repair. The observed effects suggest a complex interplay involving bone cell signalling, cytokines and bone remodelling processes as potential mechanisms underlying TDF's impact on bone quality. As a conclusion, TDF impairs bone remodelling and microarchitecture by influencing dynamic bone cell behaviour and signalling pathways. Future studies should delve deeper into understanding the intricate negative effects of TDF on bone and explore strategies for reversing these effects.

Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.

Peripheral inflammation and gait speed alterations are common in several neurological disorders and in the aging process, but the association between the two is not well established. The aim of this systematic literary review is to determine whether proinflammatory markers are a positive predictor for gait impairments and their complications, such as falls in older adults, and may represent a risk factor for slow gait speed and its complications. The systematic review was performed in line with the Preferred Report Items for Systematic Review and Meta-Analyses (PRISMA). A protocol for literature searches was structured a priori and designed according to the International Perspective Register of Systemic Review (PROSPERO: CRD42023451108). Peer-reviewed original articles were identified by searching seven electronic databases: Excerpta Medica Database (EMBASE), SciVerse (ScienceDirect), Scopus, PubMed, Medline, Web of Science, and the Cochrane Library. The search strategy was formulated based on a combination of controlled descriptors and/or keywords related to the topic and a manual search was conducted of the reference lists from the initially selected studies to identify other eligible studies. The studies were thoroughly screened using the following inclusion criteria: older adults, spatiotemporal gait characteristics, and proinflammatory markers. A meta-analysis was not performed due to the heterogeneity of the studies, and the results were narratively synthesized. Due to the clinical and methodological heterogeneity, the studies were combined in a narrative synthesis, grouped by the type of biomarkers evaluated. A standardized data extraction form was used to collect the following methodological outcome variables from each of the included studies: author, year, population, age, sample size, spatiotemporal gait parameters such as gait velocity, and proinflammatory markers such as TNF-α, high sensitivity C-reactive (CRP) proteins, and IL-6. We included 21 out of 51 studies in our review, which examined the association between inflammatory biomarkers and gait impairment. This review highlights the role of TNF-α, CRP, and IL-6 in gait impairment. Biomarkers play an important role in the decision-making process, and IL-6 can be an effective biomarker in establishing the diagnosis of slow gait speed. Further longitudinal research is needed to establish the use of molecular biomarkers in monitoring gait impairment.

Diagnostic performance of sonography in penetrating torso trauma: a systematic review and meta-analysis.

This systematic review investigates the diagnostic value of ultrasound in the evaluation of torso injuries following a penetrating trauma. We searched PubMed, Scopus, and WOS databases for related original articles until May 7, 2023, and extracted data related to diagnostic performance. The bivariate model and hierarchic summary receiver operating characteristic (HSROC) approach were used to calculate pooled diagnostic values. Cochrane Q test and I-squared were performed to evaluate heterogeneity. We assessed heterogeneity with meta-regression. Seventeen studies were included, which involved a total number of 1866 patients. According to meta-analysis, sonography demonstrated a pooled sensitivity of 56% (45-67%) and specificity of 96% (94-97%), positive likelihood ratio (LR +) of 13.66 (8.03-23.23), and negative likelihood ratio (LR-) of 0.45 (0.35-0.59) for detecting abdominal injuries. In pericardial penetrating trauma, pooled sensitivity was 100% (45-100%), pooled specificity was 99% (96-100%), LR + was 136.7 (24.8-752.3), and LR- was 0.00 (0.00-1.22). For thoracic penetrating trauma, pooled sensitivity was 99% (93-100%) and specificity was 100% (98-100%). Sonography demonstrated promising diagnostic value in the initial assessment of torso penetrating trauma, particularly in the thoracic and pericardial regions. However, the sensitivity of sonography is limited in abdominal penetrating trauma and a combination with other imaging modalities should be considered in these cases.

Cohesion, Combat Performance and Civil-Military Relations: Contextualizing “The Word of Command”

In 2006, Armed Forces & Society published my article on small unit cohesion, “The Word of Command.” It has been the focus of considerable discussion since that time. This essay describes the origins and the purpose of that 2006 article, as an attempt to contribute to an emergent “practical” paradigm in the study of cohesion. Instead of focusing on interpersonal cohesion, my original article prioritized skill—task cohesion. This commentary argues that although the political implications of small unit cohesion was subordinate in 2006, that initial article—and my wider work on cohesion—speaks directly to a key theme in the journal: civil-military relations.

Single port robot-assisted radical and simple prostatectomy: a systematic review and meta-analysis.

Aim of our study was to review the current evidence on single port robot-assisted radical prostatectomy (SP-RARP) and SP robot-assisted simple prostatectomy (SP-RASP) procedures. A comprehensive bibliographic search on multiple databases was conducted in July 2023. Studies were included if they assessed patients with non-metastatic prostate cancer or candidate for benign prostatic hyperplasia surgery (P) who underwent SP-RARP or SP-RASP, respectively, (I), compared or not with other surgical techniques (C), evaluating perioperative, oncological, or functional outcomes (O). Prospective and retrospective original articles were included (S). A meta-analysis of comparative studies between SP-RARP and MP-RARP was performed. A total of 21 studies investigating 1400 patients were included in our systematic review, 18 were related to SP-RARP while 3 to SP-RASP. Only 8 comparative studies were eligible for meta-analysis. Mean follow-up was 8.1 (±5.8) months. Similar outcomes were observed for SP-RARP and MP-RARP in terms of operative time, catheterization time, pain score, complications rate, continence and potency rates, positive surgical margin, and biochemical recurrence. Length of hospital stay was shorter in the SP group after sensitivity analysis (WMD -0.58, 95% IC -1.17 to -0.9, p < 0.05). Subgroup analysis by extraperitoneal approach did not show any statistical difference, except for a lower positive margins rate in the SP extraperitoneal technique compared to MP-RARP. Overall, SP-RASP exhibited shorter hospital stay and lower rate of de novo urinary incontinence when compared to other techniques, while no differences were reported in terms of postoperative International Prostate Symptom Score, post void residual and maximum flow. Overall comparable oncological, functional, and perioperative outcomes can be achieved with SP platform. Subgroup analysis by different approaches did not reveal significant variations in outcomes. However, the retrospective nature of the studies, the limited follow-up, and the relatively small sample size of selected Centers may impact these results.

Featured Cover

Cover illustration: The cover image is based on the Original Article Insights into the molecular basis and mechanism of heme‐triggered TLR4 signalling: The role of heme‐binding motifs in TLR4 and MD2 by Marie‐T. Hopp et al., https://doi.org/10.1111/imm.13708. image

MELASMA ETIOLOGY AND TREATMENT: A SYSTEMATIC REVIEW

Introduction: Melasma is a common chronic refractory pigmentation disorder that predominantly affects women and individuals with darker skin types. It significantly alters quality of life and self-esteem because of its disfiguring skin appearance. Objective: to detail current information related to melasma, etiology, epidemiology, pathophysiology, histology, presentation, treatment and prognosis. Methodology: a total of 30 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 19 bibliographies were used because the other articles were not relevant to this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: melasma, laser, pigmentation, skin. Results: Females are more affected than males in a 9:1 ratio. Melasma is infrequent prior to puberty and more common in the reproductive years. Melasma is found in 15% and 50% of pregnant women. The prevalence is 1.5% and 33% depending on the population. The most notable factor is exposure to sunlight. Next to pregnancy, direct sun exposure is the most important risk factor for melasma, shown by 27% to 51% of individuals as a trigger and 84% as a clinical deterioration factor. Approximately 83% to 93% of individuals with melasma have modifiable levels of solar elastosis. Conclusions: The treatment of melasma continues to be a challenge, because of the fact that the spots do not disappear completely in most of those affected, in addition to presenting considerable recurrence rates. The first line management is adequate sun protection and the association of sunscreens with color and topical bleaching agents, which may have a different effect on melanogenesis. In case oral medications are needed, tranexamic acid presents the best evidence for treatment. Some procedures support the treatment of melasma, such as microneedling and chemical peels that act through epidermal renewal. Lasers should be used with extreme caution because heat induces post-inflammatory melanogenesis. The combination of topical bleaching agents with medications and oral procedures provides more rapid effects, however more studies are needed regarding the treatment of the condition. KEY WORDS: melasma, laser, pigmentation, skin.

Beyond visual inspection: The value of infrared thermography in skin diseases, a scoping review.

Although warmth is a key sign of inflammatory skin lesions, an objective assessment and follow-up of the temperature changes are rarely done in dermatology. The recent availability of accurate, sensitive and cost-effective thermography devices has made the implementation of thermography in clinical settings feasible. The aim of this scoping review is to summarize the evidence around the value and pitfalls of infrared thermography (IRT) when used in the dermatology clinic. A systematic literature search was done for original articles using IRT in skin disorders. The results concerning the potential of IRT for diagnosis, severity staging and monitoring of skin diseases were collected. The data on the sensitivity and specificity of IRT were extracted. Numerous studies have investigated IRT in various skin diseases, revealing its significant value in wound management, skin infections (e.g. cellulitis), vascular abnormalities and deep skin inflammation (e.g. hidradenitis suppurativa). For other dermatological applications such as the interpretation of intradermal and patch allergy testing, hyper-/anhidrosis, erythromelalgia, cold urticaria and lymph node metastases more complex calculations, provocation tests or active cooling procedures are required. Dermatologists should be aware of a learning curve of IRT and recognize factors contributing to false positive and false negative results. Nonetheless, enough evidence is available to recommend IRT as a supplement to the clinical evaluation for the diagnosis, severity and follow-up of several skin diseases.

1892 Non-governmental organisations’ digital engagement in providing services for older people's needs: a scoping review

Abstract Introduction Digital technologies can play a significant role in addressing care needs of older people. The process of establishing an effective and efficient digital engagement with older people demands multi-sectoral collaboration from various stakeholders including non-governmental organisations. The role non-governmental organisations play in such digital programs, their process of engagement with older people and factors which influence such multi-sectoral collaboration is an under researched area. Methods A scoping review was performed to map existing literature on older people’s engagement with digital health technologies delivered through NGOs. The focus was on exploring the factors influencing the process of digital engagement, delineating modes of digital engagement and exploring the caring needs of older people. Multiple databases and grey literature sources were searched to retrieve articles from 2000 till 2023. JBI methodology for scoping reviews was adopted for this review. Results Out of 8970 citations, 50 articles (27 original articles, 9 reports, 12 website sources, 1 handbook and 1 research summary) were included in the final review. NGOs engage with older people either directly by delivering the program or indirectly through other program stakeholders through various inter-organisational processes (collaboration, co-ordination, partnership, delegation, sector-wide participation and association). Different types of NGOs (national, regional, provincial and local) were involved in this process of delivering care. Majority of the studies implemented programs through smartphone or tablet based digital applications. Individual factors, organisational factors, technological factors and system-wide factors influence the process of digital engagement between older people and NGOs. Conclusion The number of studies included in this scoping review, concerning older people’s engagement with digital health technologies, through NGOs were informative, but limited information was present on the process of engagement. Acknowledgement of NGOs work, and the societal role they play do also indicate that our developing digital societies more or less depend on these organisations.

Opportunistic salpingectomy at the time of vaginal hysterectomy: A systematic review and meta-analysis.

Despite the rising rates of opportunistic salpingectomy at the time of surgery for non-malignant conditions, salpingectomy is not widely adopted during vaginal hysterectomy (VH) and has not been extensively investigated. The aim of the primary study was to determine the feasibility of bilateral opportunistic salpingectomy at the time of VH. Secondary aims included surgical outcomes, factors associated with patient selection, and the prevalence of incidental tubal malignancies. In this systematic review and meta-analysis we searched Pubmed, Embase and ClinicalTrials.gov databases from inception to September 1, 2023, using relevant keywords. Original articles with no language restriction reporting outcomes of women undergoing planned VH with opportunistic salpingectomy, were considered eligible. Studies including patients undergoing VH with and without opportunistic salpingectomy were also included. The Newcastle-Ottawa scale was used to assess quality of observational studies. DerSimonian-Laird random effects meta-analysis was performed and pooled effect estimates and proportions with corresponding 95% confidence intervals were computed. Heterogeneity was assessed using the I2 statistic. Seven observational cohort studies including 4808 women undergoing opportunistic salpingectomy at the time of VH and 10 295 patients undergoing VH alone were selected. The pooled proportion of success was 81.83 per 100 observations (95% CI: 75.35-87.54). Opportunistic salpingectomy at the time of VH, when feasible, was associated with a significant reduction in intraoperative complications (OR 0.06, 95% CI: 0.01, -0.37, P = 0.03) and total operative time (95% CI: -17.80, -1.07, P = 0.03) compared to those where it failed. Successful salpingectomy was significantly hindered by nulliparity (OR 0.12, 95% CI: -17.69, -1.21, P < 0.001) and favored by pelvic organ prolapse (OR 3.20, 95% CI: 1.35, 7.55, P = 0.008). Immunohistochemical tubal abnormalities were found in 13/579 (2.1%) patients. The overall quality of the evidence, according to the GRADE assessment, was low. Opportunistic salpingectomy is safe, effective, and feasible at the time of VH. Nulliparity and pelvic organ prolapse are factors potentially influencing surgical outcomes.

COVID-19 and Sleep Problems: A Perspective from Bibliometric Analysis

ABSTRACT Objectives The Coronavirus Disease 2019 (COVID-19) pandemic and the containment measures for COVID-19 have affected sleep quality in the population. This study explored sleep-related research from a bibliometric perspective to provide an overview of the research outputs in this field. Methods Original and review articles were retrieved from the Web of Science Core Collection (WOSCC) database from December 2019 to 7 Aug 2023. R package “bibliometrix” was used to summarize the number of articles of authors, institutions, and countries; count the citations of the articles, and generate a Three-Fields Plot. VOSviewer software was applied to visualize the collaboration network among authors and institutions, and to conduct a co-occurrence analysis of keywords. Results A total of 4,499 articles on COVID-19 and sleep, and 25,883 articles on non-COVID-19 and sleep were included. Sleep related articles were mainly published by authors from China, the USA, and Italy. For COVID-19 and sleep research, Huazhong University of Science was the most productive institution. The Psychiatry Research was the most influential journal across the different subject categories of this field. “Mental health”, “anxiety”, and “depression” were the most common keywords, while “sleep quality” and “quality of life” were the likely topic areas in terms of future research directions. Conclusions Our findings provide a comprehensive perspective for researchers to understand the wider landscape of both COVID-19 and non-COVID-19 sleep-related research area.

Impact analysis of primary and secondary research in radiology journals

IntroductionPrimary and secondary studies are considered the two major research categories. In this study, we examined the scientific and social media impact of primary and secondary publication types in papers published radiological journals during 2010–2020. Materials and methodsPubMed publication type tags were used to filter original articles and systematic review and meta-analysis (SR/MA) articles. Clarivate Web of Science was utilized to obtain a list of all radiology journals from the category “Radiology, Nuclear Medicine and Imaging” in Science Citation Index Expanded (SCIE). Automated approach was developed for programmatic extraction of bibliometric and Altmetric yearly citations of each included article using Dimensions API and Altmetric API with Python. Statistical analysis was performed to compare the citation rates between primary and secondary research articles. ResultsA total of 96,684 published articles from 2010 to 2020 were identified and their meta-data collected. The mean 2-year citation count following publication year was 5.8 for primary research and 10.2 for SR/MA articles (p < 0.001). Between 2010 and 2020, the mean number of citations per SR/MA article was 51.3 compared to 30.5 per primary research article (p < 0.001). Mean Altmetric score was 8.2 in SR/MA compared to 3.7 for primary research articles (p < 0.001). ConclusionSecondary research studies have been increasing in impact in both academia and social media compared to primary research. Our results highlight the importance and impact of systematic reviews and meta-analysis articles as a scientifically influential study type in radiology.

Neurobehavioural rehabilitation of dysexecutive syndrome following traumatic brain injury - a narrative review of management

Background: &#x0D; Traumatic brain injury (TBI) leads to &gt;200,000 hospital admissions in the UK annually. Frontal lobes are frequently affected, leading to a sequela of symptoms affecting behaviour, emotions, and cognition; a cluster of symptoms referred to as dysexecutive syndrome (also known as frontal lobe syndrome). People who survive this, experience long-term sequelae and require long-term support through neurological rehabilitation. The UK has robust guidelines on the medical/physical aspects of rehabilitation following brain injury. However, these guidelines mention little information on the management of neurobehavioural problems following TBI. The aim of this review is to determine what the evidence-based neurobehavioural management of patients with dysexecutive syndrome following TBI is in the UK.&#x0D; &#x0D; Methods: &#x0D; A systematic review of articles using MEDLINE, EMBASE (1974 – present) and Web of Science was conducted. Search terms included frontal lobe syndrome, dysexecutive syndrome, traumatic brain injury, neurorehabilitation, neurological rehabilitation, neurological management, behaviour therapy and behavioural management. Additional references were sourced from the search results and author NH, a medical director within a hospital catering to people with brain injury.&#x0D; &#x0D; Results: &#x0D; 168 results were obtained. 21 articles remained following exclusions: 19 original articles and 2 reviews. Interventions mentioned included: behavioural psychotherapy, memory training, feedback, awareness interventions, goal management training, social skills training, work placements, problem solving training, metacognitive skills, token economy and response cost. Interventions were utilised using a person-centred approach, however, generally there was a lack of consensus as the most effective one. Only 2 studies considered the long-term outcomes of rehabilitation.&#x0D; &#x0D; Discussion:&#x0D; Successful rehabilitation of dysexecutive syndrome post-TBI involves using a person-centred approach, to determine which intervention will target the problem of concern to the patient. Few papers address behavioural rehabilitation of dysexecutive syndrome post-TBI. Further research is required to determine the most effective and beneficial interventions for patients in both the short- and long-term.

Urinary biomarkers in children with neurogenic and non-neurogenic lower urinary tract dysfunction: A systematic review and meta-analysis.

The aim of this systematic review is to assess urinary biomarkers studied in children with neurogenic and non-neurogenic lower urinary tract dysfunction (LUTD). The systematic review was conducted in accordance with the PRISMA guidelines. The screening was performed on PUBMED without any publication date limitation. Only original articles were included. Parameters related to the following topics were obtained: study design, characteristics of participants, number of participants, age, control group, types of biomarkers, measurement technique in urine, subgroup analysis, urodynamic findings, and outcome. Dutch Cochrane Checklist (DCC) and level of evidence by EBRO platform were used for quality assessment. Meta-analysis was performed with the Comprehensive Meta-Analysis Version 4 program. A total of 494 studies were screened and 16 studies were included. 11 (68.75%) were conducted in children with non-neurogenic LUTD and 5 (31.25%) neurogenic LUTD. Nerve growth factor (NGF) was evaluated in 12 studies, brain-derived neurotrophic factor (BDNF) in 5, Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) in 2, transforming growth factor beta-1 (TGF Beta-1) in 2, neutrophil gelatinase-associated lipocalin (NGAL) in 1, and Aquaporin-2 in 1. According to DCC, 10 (62.5%) articles were evaluated on 4 (37.5%) items and 4 articles on 5 items. The average score was 3.91+/-0.56. The level of evidence was found as B for 13 (81.25%) articles and C for 3 (18.75%). In meta-analysis, urinary NGF levels in children with non-neurogenic LUTS were significantly higher than in the healthy control group (Hedges's g = 1.867, standard error = 0.344, variance = 0.119, p = 0.0001). Urinary biomarkers are promising for the future with their noninvasive features. However, prospective studies with larger sample sizes are needed to better understand the potential of urinary biomarkers to reflect urodynamic and clinical findings in children with LUTD.

Networked lives: Probing the influence of social networks on the life course

Social network research is well-equipped to help life course scholars produce a deeper and more nuanced approach to the principle of “linked lives,” one of the cornerstones of the field. In this issue on Networked Lives, nine original articles and two commentaries generate new theories, empirical findings and methodological applications at the intersection of the fields of social networks and life course research. In this introduction, we reflect on these advances, highlighting key findings and challenges that await scholars in building more robust synergy between the two fields. Social networks emerge as key structural forces in life courses, yet there is much to learn about the mechanisms through which their effects on people’s lives come about. There is a need to study further how networks evolve through the rhythm of life events, and to analyze broader and more complex networks that capture the roles and influences of relations beyond intimate or family ties. These papers demonstrate that there is much to be gained in probing how individuals are linked to and unlinked from others over time, and in carrying conceptual and methodological advances across social network and life course studies.

Observational Methods in Studies of Infant and Young Child Feeding Practices in Low- and Middle-Income Countries: A Twenty-Year Retrospective Review.

This narrative review describes the observational approaches used to study infant and young child feeding (IYCF) practices in low- and middle-income countries (LMICs) published between 2001 and 2021. Articles were included in this narrative review if they were (1) original peer-reviewed articles published in English in PubMed and Web of Science; (2) published between 1 January 2001, and 31 December 2021; (3) conducted in an LMIC; and (4) employed observations and focused on IYCF practices among children aged 6-59 months. The studies (n = 51) revealed a wide-ranging application of direct meal and full-day observations, as well as indirect spot checks, to study IYCF. The findings revealed that meal observations were typically conducted during a midday meal using precise recording approaches such as video and aimed to understand child-caregiver interactions or specialized nutritious food (SNF) usage. Conversely, full-day observations lasted between 6 and 12 h and often used a field notes-based recording approach. Behaviors occurring outside of mealtime, such as snacking or interhousehold food sharing, were also a primary focus. Finally, spot checks were conducted to indirectly assess SNF compliance during both announced and unannounced visits. This review highlights the adaptability of observations across contexts and their versatility when used as a primary data collection tool to help monitor and evaluate nutrition programs.

Mapping knowledge landscapes and emerging trends of non-contact vital signs monitoring: A bibliometric and visualization analysis from 2002 to 2023

This study makes a comparative analysis based on knowledge mapping of Chinese and English publications on non-contact vital signs monitoring and provides a reference for future research and development. Publications were retrieved from Web of Science (WoS) and PubMed, China National Knowledge Infrastructure (CNKI), and Wanfang databases from January 1, 2002 to October 31, 2023. Bibliometric analysis was performed using CiteSpace software. Information from 612 English and 543 Chinese original research articles was collected and analyzed. The maximum number of English appeared in 2022 and the maximum number of Chinese articles appeared in 2020, and the number of articles published afterward declined slightly. For the articles published in English, USA and China shared the highest number of publications. Chinese Academy of Sciences was the most published institution. Steffen Leonhardt was the highest-published author. Meanwhile, within the Chinese articles, the most productive province was Beijing. The most productive institution was the Air Force Medical University. The most productive author was Weixue Liu. The research institutions and authors of English and Chinese articles were decentralized. The hotspots of the English articles mainly were “heart rate” and “respiratory rate”, and the Chinese articles focused on “temperature” and “heart rate”. Concluding, the research on non-contact vital signs monitoring is in a booming phase of development at present. Non-contact heart rate monitoring is a popular research direction in English and Chinese research. In the future, research institutions and authors should strengthen their cooperation and communication to promote the development of this research area.

Historical evolution of cancer genomics research in Latin America: a comprehensive visual and bibliometric analysis until 2023.

Background: Cancer genomics, as an interdisciplinary research area within the Global Cancer Research agenda, genomics and precision medicine, its important in research and clinical practice in Latin America. To date, there has been no study investigating evolution of this area in this region. The aim of this study was to evaluate for first time, the historical evolution of cancer genomics research in Latin America. Methods: Bibliometric cross-sectional study of documents on cancer genomics published by Latin American authors until 2023 in Scopus was performed. Statistical and visual analysis was performed with R programming language. Results: A total of 1534 documents were obtained. The first document of cancer genomics research was published in 1997, marking the inception of a 26-year evaluation period that extended until 2023. Among the documents, 74.3% (n = 1140) constituted original articles, followed by 22.7% (n = 349) classified as reviews. International collaboration was observed in 6.5% (n = 100) of the articles. Within the compilation of the ten most prolific authors in this region, 90% of them are from Brazil. This observed pattern extends to affiliations as well, wherein the Universidade de São Paulo emerges as the most active institution (n = 255 documents). This arrangement firmly establishes Brazil's prominence as the preeminent country in the region concerning cancer genomics research, showcasing robust collaboration networks both regionally and intercontinentally. An important transition in the studied hot topics over the last 20years was identified, from the exploration of the human genome and the characterization of genomic and proteomic cancer profiles (1997-2010) to an in-depth investigation of cancer stem cells and personalized medicine (2011-2023). Among the array of cancer types under study, predominant attention has been directed towards breast, lung, prostate, and leukemia. Conclusion: Over the course of the past 26years, a favorable and notable evolution has characterized cancer genomics research within Latin America, with Brazil leading the way, which possess a robust network of regional and intercontinental collaboration. Furthermore, the lines of research and hot topics have change in harmony with the region's objectives, strategies, and requisites.

Cover Image

The cover image is based on the Original Article Single‐cell sequencing identifies inflammation‐promoting fibroblast–neutrophil interaction in peri‐implantitis by Jia‐ji Mo etal., https://doi.org/10.1111/jcpe.13912.image