Original Account Research Articles

Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report.

Carcinomas of unknown primary origin account for 3-5% of all malignancies. The current literature suggests that metastatic dissemination is able to occur in the absence of primary tumor growth. In metastatic disease that is difficult to diagnose, the origin usually remains unknown even after an exhaustive evaluation of immunohistochemistry (IHC) markers. In the current study, a 49-year-old male presented with lymph nodes metastases of unknown origin. The excisional biopsy of an inguinal node revealed an adenocarcinoma growth pattern, but the IHC could not determine the primary origin. A gene profiling test was performed to complete the diagnosis and a salivary gland adenocarcinoma was diagnosed with 90% probability. Subsequently, the patient underwent appropriate chemotherapy for salivary gland adenocarcinoma, and exhibited an improved partial response. The present case study highlights the importance of an accurate diagnosis of the primary tumor and the use of all the current tools available in order to provide patients with the best treatment possible.

The relation between content providers and distributors: Lessons from the regulation of television distribution in the United Kingdom

Using the United Kingdom (UK) as a case study, this article analyses the growing commercial and regulatory significance of broadcaster–distributor relations within the contemporary television industry. The first part of the article argues that despite important changes in broadcast delivery technology, more recently shaped by the growth of the Internet, and the associated growth of options of receiving television content, the traditional delivery platforms (digital terrestrial, satellite and cable) remain by far the preferred choice for viewers in Britain. At the same time, public service broadcasters continue to be the biggest investors in domestic original non-sport content and account for over half of all television viewing. The strength of PSBs in content and their growing reliance on commercial proprietary subscription platforms (cable and satellite) and gradually on the Internet presents challenges in the nexus between broadcasters and distributors. The article focuses on the debate over retransmission fees between PSBs and Sky, and on the question of whether Sky should be required to offer some of its premium content to rival pay-TV platforms. These two examples highlight the impact regulatory intervention can have on the balance of power between broadcasters and distributors. The article concludes that such debates concerning the commercial relations between content providers and distributors will remain pivotal and become more heated given that similar issues are raised in the Internet environment.

Myths of tourism institutionalization and Cancún

This interdisciplinary investigation revisits Cancún’s origins and tourism institutionalization. Original accounting documents separate myth and marketing from events to debunk widely disseminated misconceptions of the Mexican state’s role. This rare view of mass tourism emergence at a (trans)formative period demonstrates the historical processes, personalities and ploys. Against a backdrop of conflicts, a banking alliance sparked integrally planned tourism centers. Cancún was the brainchild of economics-trained central bankers inexperienced in tourism with a mandate to increase foreign revenue. Amid looming failure, the bankers swapped land-for-shares to portray the project as a financial success to its stakeholders. Combined with fiscal sociology, organizational theory institutionalization through a six-stage process serves to incrementally reveal the introduction of central planning, the linchpin of Mexico’s tourism predominance.

The schizophrenic jury and other palladia of liberty: a critical historical analysis

The historiography of the jury is interestingly schizophrenic, even paradoxical. On one side is the once traditional, and still popular, history of the jury as palladium of liberty. On the other side is the once revisionist, but now widely accepted, account of the jury's origin as instrument of oppression. On one side is the jury as English, local, indigenous, democratic; on the other is the jury as French, central, foreign, autocratic. This paper reflects on this apparent paradox, regarding it as neither sui generis nor in need of resolution. Instead, from the longue durée comparative-historical perspective of New Historical Jurisprudence, the schizophrenic history of the jury and of other palladia of liberty, notably habeas corpus, can be seen to reflect the fundamental and long-standing tension between two modes of governance, law and police, rooted in the distinction between autonomy and heteronomy that has shaped the Western legal-political project since classical Athens.

Reichenbach on causality in 1923: Scientific inference, coordination, and confirmation

In The Theory of Relativity and A Priori Knowledge (1920b), Reichenbach developed an original account of cognition as coordination of formal structures to empirical ones. One of the most salient features of this account is that it is explicitly not a top-down type of coordination, and in fact it is crucially “directed” by the empirical side. Reichenbach called this feature “the mutuality of coordination” but, in that work, did not elaborate sufficiently on how this is supposed to work. In a paper that he wrote less than two years afterwards (but that he published only in 1932), “The Principle of Causality and the Possibility of its Empirical Confirmation” (1923/1932), he described what seems to be a model for this idea, now within an analysis of causality that results in an account of scientific inference. Recent reassessments of his early proposal do not seem to capture the extent of Reichenbach's original worries. The present paper analyses Reichenbach's early account and suggests a new way to look at his early work. According to it, we perform measurements, individuate parameters, collect and analyse data, by using a “constructive” approach, such as the one with which we formulate and test hypotheses, which paradigmatically requires some simplicity assumptions. Reichenbach's attempt to account for all these aspects in 1923 was obviously limited and naive in many ways, but it shows that, in his view, there were multiple ways in which the idea of “constitution” is embodied in scientific practice.

Override the controversy: Analytic thinking predicts endorsement of evolution

Despite overwhelming scientific consensus, popular opinions regarding evolution are starkly divided. In the USA, for example, nearly one in three adults espouse a literal and recent divine creation account of human origins. Plausibly, resistance to scientific conclusions regarding the origins of species—like much resistance to other scientific conclusions (Bloom & Weisberg, 2007)—gains support from reliably developing intuitions. Intuitions about essentialism, teleology, agency, and order may combine to make creationism potentially more cognitively attractive than evolutionary concepts. However, dual process approaches to cognition recognize that people can often analytically override their intuitions. Two large studies (total N=1324) found consistent evidence that a tendency to engage analytic thinking predicted endorsement of evolution, even controlling for relevant demographic, attitudinal, and religious variables. Meanwhile, exposure to religion predicted reduced endorsement of evolution. Cognitive style is one factor among many affecting opinions on the origin of species.

Plotinus on the Inner Sense

Recently, there has been a growing interest in ancient views on consciousness and particularly in their influence on medieval and early modern philosophers. Here I suggest a new interpretation of Plotinus’s account of consciousness which, if correct, may help us to reconsider his role in the history of the notion of the inner sense. I argue that, while explaining how our divided soul can be a unitary subject of the states and activities of its parts, Plotinus develops an original account of consciousness that appeals to an inner sense. In contrast to ‘the outer senses’, which perceive sensible things out there in the world, this sense, for him, perceives the activities of the parts of our soul, thus enabling us to be conscious of them as a single subject. I suggest that Plotinus devises his account of this psychic power in the light of Alexander of Aphrodisias’s interpretation of the Aristotelian ‘common sense’. Since in Alexander the ‘common sense’ enables us to be conscious as a single subject of sensations from different modalities, Plotinus uses it as a model to explain how we can be the conscious subject of all the states and activities of our soul.

Higher education and economic development: The importance of building technological capabilities

Higher education and development has not been a priority of global policy or research funding in recent decades. Yet, since the millennium, Southern governments have become believers in the global knowledge economy and higher education enrolment growth has been phenomenal. In this paper we offer an original account of how higher education institutions contribute to economic development by drawing on evolutionary economics and the national innovation systems approach. This offers distinct advantages in conceptualising higher education’s developmental role, through its stress on the importance of education, skills, work, innovation and production for economic development. Using these concepts, we examine how well South African higher education is positioned to contribute to economic development through a consideration of two case studies from astronomy and automotives. These highlight the importance of the intersection between global, national, sectoral and spatial dimensions of the education—economic development relationship. We suggest that dynamics at multiple scalar levels work in complex ways to shape possibilities for development. We argue that such an approach offers a way forward for international education and development thinking about the relationship between education, technological innovation, production and development.

The Great Barrier Reef: an environmental history

This book provides an original account of the environmental history of the Great Barrier Reef, based on extensive archival and oral history research. It documents and explains the main human impacts on the Great Barrier Reef since European settlement in the region, focusing particularly on the century from 1860 to 1960 which has not previously been fully documented, yet which was a period of unprecedented exploitation of the ecosystem and its resources. The book describes the main changes in coral reefs, islands and marine wildlife that resulted from those impacts. The author provides a compelling narrative of how one of the world's most iconic and vulnerable ecosystems has been exploited and degraded, but also how some early conservation practices emerged.

From reviving tradition to fostering innovation and changing marketing: the evolution of micro-brewing in the UK and US, 1980–2012

The purpose of this article is to explore and examine the impressive growth of small and micro-breweries registered in the UK and US from the early 1980s. While the majority of British and American breweries continue to operate in spatially restricted areas and niche markets, a few businesses expanded significantly in terms of production and turnover, gradually acquiring larger shares of the market and competing with multinational producers at home as well as abroad. The cases of BrewDog and Sierra Nevada, used as case study examples in this article, provide an original account on how once-upon-a-time micro-breweries grew into well established companies by pursuing aggressive strategies in terms of marketing and innovation respectively.

Durkheim, Sellars, and the Origins of Collective Intentionality

Wilfrid Sellars read and annotated Celestine Bouglé’s Evolution of Values, translated by his mother with an introduction by his father (1926). The book expounded Émile Durkheim's account of morality and elaborated his account of origins of value in collective social life. Sellars replaced elements of this account in constructing his own conception of the relationship between the normative and community, but preserved a central one: the idea that conflicting collective and individual intentions could be found in the same person. These notoriously opaque arguments, which seek to save an element of rationalism from social explanation while granting the claims of behavioural science, are illuminated by comparing them to their original Durkheimian form.

Fecundity of silver-phase eels (Anguilla anguilla) from different habitat types and geographic locations

Abstract The reproductive ecology of European eel (Anguilla anguilla) is poorly understood, though information on life-history traits such as fecundity is necessary for appropriate management of this critically endangered species. During the growth period of the life cycle, yellow-phase eels can be resident in different habitat types (e.g. salinity ranging from freshwater to marine) over a wide geographic distribution. Consequently, maturing silver-phase eels migrating back to the oceanic spawning grounds can display considerable variation in certain life-history traits depending on their habitat and/or geographic origin. Few fecundity estimates are available from wild A. anguilla, and no investigation of the effects of habitat type (i.e. salinity) or geographic location on variation in fecundity has been undertaken. To assess the former, we examined silver-phase eels which had predominantly been resident in freshwater (Lake Mälaren, Sweden) or brackish (Baltic Sea) habitats. Despite Lake Mälaren eels generally being larger, there was no difference in the fecundity–body size relationship between these salinity zones. Second, we determined if fecundity differed between silver-phase eels sampled from different geographic locations: Lake Mälaren and the Baltic Sea outlet in Sweden, the River Shannon in Ireland (northwest Europe) and Vistonis Lake in Greece (eastern Mediterranean). Our results showed that silver-phase eels from Sweden (Lake Mälaren and Baltic Sea outlet) and Greece were significantly more fecund at a given body size than those from Ireland. Spawner models and conservation policies should therefore take account of eel geographic origin in particular when incorporating this life-history parameter.

Justice and Constructivism

Albert Weale's Democratic Justice and the Social Contract is an important book. It offers an innovative and original (proceduralist) account of justice. In so doing, it places what Brian Barry called ‘the empirical method’ at the centre of normative political philosophy's attempts to generate determinate answers to moral questions. This article-written from the perspective of someone sympathetic to both the commitment to mutual advantage and the empirical method – focuses on the kind of argument it is that Weale is offering and in particular on the nature of his constructivist project. It argues that Weale's commitment to equality lies outside the constructivist project and that this undermines his aspiration to genuine constructivism. The article goes on to consider, on the basis of arguments found in Democratic Justice and the Social Contract, various ways in which Weale might have grounded his egalitarian commitments from within the constructivist project.

Groundwater cyclopoid copepods of peninsular India, with description of eight new species

To date, only three stygobiotic cyclopoid species are known from India: Haplocyclops (Kiefercyclops) fiersi Karanovic & Ranga Reddy, 2005 and Rybocyclops dussarti Ranga Reddy & Defaye, 2008, from bores, and Allocyclopina inopinata Defaye & Ranga Reddy, 2008, from brackish conditions of a hyporheic habitat. Analysis of numerous groundwater samples collected during 2008-2013 from the hyporheic and phreatic habitats in the coastal deltaic belt of the Rivers Krishna and Godavari in Andhra Pradesh state, southeastern India, has shown ten stygobiotic cyclopoid species, of which eight are new to science: Anzcyclops indicus n. sp., Brevicyclops asetosus n. g., n. sp., Brevicyclops brevisetosus n. g., n. sp., Brevicyclops viduus n. g., n. sp., Halicyclops martinezi n. sp., Haplocyclops (Kiefercyclops) godavari n. sp., Haplocyclops (Kiefercyclops) primitivus n. sp., and Rybocyclops defayeae n. sp. All these species are formally described and illustrated herein. Allocyclopina inopinata, which perfectly agrees with its original account, is also recorded in several localities besides its type locality. The heretofore incompletely characterised Paracyclopina orientalis (Lindberg, 1941) is redescribed. A new cyclopid genus, Brevicyclops n. g., is established for three aforementioned new species. Its most diagnostic synapomorphy is the extreme reduction or complete absence of the principal outer apical seta of caudal ramus. So far, the cosmopolitan genus Halicyclops Norman, 1903, is known by six species in India, all from the surface environments. Now, a new species, H. martinezi n. sp., is described from an interstitial hyporheic habitat, and an identification key given for all the Indian species. The genus Anzcyclops Karanovic, Eberhard & Murdoch, 2011, which has hitherto been known from the Western Australia and New Zealand, is discovered in this study. A new species, Anzcyclops indicus n. sp., which has a close relationship with its Western Australian congeners, is described. A brief note on the biogeography of the Indian stygobiotic crustaceans is also added.

Speed limits: where time went and why we have so little left

We live in an ever-accelerating world: faster computers, markets, food, fashion, product cycles, minds, bodies, kids, lives. When did everything start moving so fast? Why does speed seem so inevitable? Is faster always better? Drawing together developments in religion, philosophy, art, technology, fashion, and finance, Mark C. Taylor presents an original and rich account of a great paradox of our times: how the very forces and technologies that were supposed to free us by saving time and labor now trap us in a race we can never win. The faster we go, the less time we have, and the more we try to catch up, the farther behind we fall. Connecting our speed-obsession with today's global capitalism, he composes a grand narrative showing how commitments to economic growth and extreme competition, combined with accelerating technological innovation, have brought us close to disaster. Psychologically, environmentally, economically, and culturally, speed is taking a profound toll on our lives. By showing how the phenomenon of speed has emerged, Taylor offers us a chance to see our pace of life as the product of specific ideas, practices, and policies. It's not inevitable or irreversible. He courageously and movingly invites us to imagine how we might patiently work towards a more deliberative life and sustainable world.

Trust and social capital in the design and evolution of institutions for collective action

This paper aims at developing an original account of trust in the framework of large scale, international collective action institutions. Our research question focuses on the desired structures and mechanisms that are necessary to sustain the trust needed to uphold the effective operation of institutions for collective action. Our theoretical framework for studying trust is based on the social capital theory. Social capital is defined as the features of social organization, such as trust, networks and norms that facilitate coordination and cooperation for mutual benefit. We claim that in different sectors and contexts stakeholders encounter difficulties in collaborating in setting up experimental institutions for collective action. In order to generate more collaboration, stakeholders need to create structures that incite actors to find the optimal way to sustain trust, to organizationally acknowledge and learn that process, and to nourish it with the precise normative idea behind the institutional apparatus. In the areas of plant genetic resources and biomedicine, stakeholders have encountered these difficulties while experimenting with different coordination mechanisms for dealing with the increased appropriation of knowledge through patents. Our two case studies in plant genetic resources and biomedicine reflect the idea that institutions must be understood as complex pragmatic connectors of trust, i.e. social matrices of collective action that sustain individual commitment, where routine and reflexivity drive trust-based coordination mechanisms in interaction with their environment. From this theoretical framework we derive some recommendations that could be useful in deciding on how to implement this idea.

Word Order, Action, and the Brain: A Reply to Arbib

AbstractIn a recent paper in this journal, I argued that the crosslinguistic prevalence of subject–object–verb and subject–verb–object word orders reflects the sequential and hierarchical representation of action in Broca's area. Arbib (2015) discusses that paper in the context of broader computational, neuroscientific, and evolutionary issues, and presents a critique of my specific proposal. Here, I respond to his concerns and defend my original account.

Biometric security system over finite field for mobile applications

Recently, number of mobile users and mobile banking applications are increased dramatically. The current mobile banking system unable to provide face-to-face transaction, that is, anyone can perform transaction by using proper secret code. This study proposes a new triangular based indexing method to authenticate the original account holder in mobile banking environment. A Delaunay triangulation indexing scheme has been designed for protecting biometric template and Voronoi vertex is calculated for verifying the authorised person. A novel algorithm has been developed for mutual authentication. To reduce key size, elliptic curve cryptography technique is adapted. Biometric key is generated for secure communication and also discusses the security aspects of the proposed method.

Equality for inegalitarians

This book offers a new and compelling account of distributive justice and its relation to choice. Unlike luck egalitarians, who treat unchosen differences in people's circumstances as sources of unjust inequality to be overcome, Sher views such differences as pervasive and unavoidable features of the human situation. Appealing to an original account of what makes us moral equals, he argues that our interest in successfully negotiating life's ever-shifting contingencies is more basic than our interest in achieving any more specific goals. He argues, also, that the state's obligation to promote this interest supports a principled version of the view that what matters about resources, opportunity, and other secondary goods is only that each person have enough. The book opens up a variety of new questions, and offers a distinctive new perspective for scholars of political theory and political philosophy, and for those interested in distributive justice and luck egalitarianism.

The Development of Chinese Accounting and Bookkeeping Before 1850: Insights from the TTng TTi Shhng Business Account Books (1798-1850)

Since China’s ‘reform and opening up’ policy began in 1978 there has been increasing interest in how Chinese business activity was organised during the era before the imposition of central planning under Chairman Mao. Some business archives from that era have now been discovered and examined by Chinese scholars but the businesses and their accounts have mostly been of a relatively simple nature or have clearly reflected the increasing influence of Western businesses (and Western double-entry bookkeeping [DEB]) that was disseminated through the ‘treaty ports’ (such as Shanghai) established from around the middle of the 19th century following the Opium Wars. In this paper we report our exploration into the original account books contained in the archive of Tŏng Tai Shēng (‘TTS’), which has recently been discovered and is the largest such archive examined so far. It yields important data about economic activity but our focus here is on the accounting practices it reveals. TTS was a substantial ‘grocery/merchant-banking’ business in northern China and its surviving books span a period from the late 18th century to the middle of the 19th century. They may therefore be regarded as representing primarily ‘indigenous’ Chinese bookkeeping practices. We set out the various kinds of accounts that were kept and what can be reconstructed of the interrelationships between daily running records and the various ‘ledger’ accounts for customers and suppliers (including loans at interest) and of the process by which financial statements were produced. We give illustrations of important accounts and also explain the specialist system of numerals used for accounting purposes, the Sūzhōu măzi [苏州码字]. Given the claims that have repeatedly been made for the importance of DEB for capitalism’s development in the West, our findings from examining this extensive collection of original account books are important for understanding the nature of Chinese bookkeeping and accounting and its role in China’s economic development.