Pitting corrosion is of particular concern to the navy because while significant progress has been made in preventing uniform and general corrosion, the possibility of corrosion pits transitioning to crack initiation sites remains a persistent threat with potentially catastrophic consequences. Beyond considerations for the magnitude and mode of mechanical loading, the transition from pit to crack may be influenced by the prevailing electrochemical environment and the microstructural composition of the corroding material. Additionally, both the microstructure and evolving pit morphologies will directly affect local stress concentrations, potentially leading to crack initiation. Until recently, most studies of pitting corrosion, with or without the application of mechanical load, have dealt with the phenomenon from an electrochemical and compositional perspective at the macroscale and have not considered the microstructure nor changes in the evolving pit shape over time. This work presents an investigation of how underlying microstructures can influence the pitting corrosion process, and the resulting stress distributions around pits, through a multi-physics computational modeling framework that incorporates crystallographic orientation dependencies into both the corrosion potential and mechanical response. This is accomplished by importing a microstructure’s orientation data, i.e., the Euler angle information, directly into the computational modeling domain in order to provide crystallographic information.Based on this modeling paradigm, computational simulations are conducted using both experimental and synthetic microstructures for conventionally and additively manufactured stainless steel alloys. Experimental microstructures are provided from electron backscatter diffraction data, while the synthetic microstructures are generated using DREAM3D software. The computational modeling framework utilizes phase field methods to resolve the moving pit boundary while the underlying concentration and displacement gradients are solved over a finite element mesh. Over the course of the simulations, the orientation dependence of the corrosion potentials, and ensuing corrosion current densities, lead to non-uniform growth and propagation of the pit throughout the model domain as it evolves over time, producing irregular pit morphologies. Further, the microstructural influence on mechanical response is measured through differences in peak stresses and stress concentrations along the pit boundary, as well as stress intensity factors. This work highlights the significant local impact microstructure has on the pitting corrosion process and contrasts these impacts over different manufacturing processes (conventional vs. additive) for the same alloy system.