Organometallic Framework Research Articles

Human serum albumin microspheres synchronously loaded with ZIF-8 and triptolide (TP) for the treatment of intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in most patients. Only 20% to 30% of patients can be treated with potentially curative surgical resection. Local therapies such as radioembolization and hepatic arterial perfusion may be a more effective treatment strategy. The active ingredients of natural plants have aroused wide interest in the treatment of tumors. Triptolide shows toxic effects on a variety of epithelioid carcinoma cells. However, there is currently a lack of suitable delivery system for the treatment of ICC. In this study, organometallic framework material ZIF-8 was chosen to load TP, and then encapsuled in HSA micro-nanoparticles for the perfusion treatment of ICC. The results of SEM, XRD, and FTIR showed that ZIF-8 nanoparticles were encapsuled in HSA micro-nanoparticles. ZIF-8 nanoparticles (57.89 ± 12.24%) and TP@ZIF-8/HSA (36.8 ± 4.71%) micro-nanoparticles could significantly inhibited proliferation of RBE cell. Also, TP@ZIF-8/HSA micro-nanoparticles of all groups exhibited favorable cytocompatibility to L929 cells and hemocompatibility. RT-qPCR and western blot showed that ZIF-8 and TP induced apoptosis in cancer cells through mitochondria-related pathways. The results demonstrated that TP@ZIF-8/HSA was a potential chemotherapy candidate for the treatment of ICC.

Metal Bis(acyclic diaminocarbene)-Derived Homochiral Organometallic Frameworks: Synthesis and Asymmetric Catalytic Application.

As an indispensable member of the reticular material family, metal-carbon-based organometallic frameworks (OMFs) remain largely underexplored, and no chiral OMFs (COMFs) have been reported thus far. Herein, we first report the construction of COMFs from a Pd-isocyanide OMF via nucleophilic addition to the Pd-isocyanide moiety with optically pure amines. The obtained Pd-bis(acyclic diaminocarbene) (Pd-BADC)-derived chiral OMFs display excellent applicability and can be reusable chiral catalysts to highly promote asymmetric Strecker and Suzuki-Miyaura cross-coupling reactions in a heterogeneous way. We anticipate that this type of chiral reticular material will be applicable to a broad range of asymmetric catalytic applications, and this appealing synthetic strategy will likely provide access to more other such materials with unprecedented structures and catalytic activities.

Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions

BackgroundInadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework under ketogenic conditions in inhibiting the growth of MIA-PaCa-2 cells.MethodsGemcitabine was encapsulated in Metal–organic frameworks (MOFs) and its morphology and size distribution were examined using transmission electron microscopy (TEM) and Dynamic light scattering (DLS) with further characterization including FTIR analysis. Various drug groups were established to evaluate their influences on cell cytotoxicity, apoptosis rate, cell cycle distribution, levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), and cell migration.ResultsThe gemcitabine-MOF was thoroughly analyzed to determine its size, morphology, and chemical composition, confirming its successful preparation. The treatment results showed an increase in the number of apoptotic cells following gemcitabine-MOF treatment, which was found to be associated with cell cycle arrest in the sub-G1 phase. Moreover, these treatments also resulted in reduced cell migration, decreased activity of antioxidant enzymes (SOD, GPx), and increased accumulation of MDA. Additionally, when exposed to ketogenic conditions (where beta-hydroxybutyrate is present in a glucose-limited medium), there was a further increase in cell cycle arrest, accompanied by a more pronounced decrease in SOD and GPx activity, as well as decreased migration.ConclusionThe use of metal–organic framework to encapsulate gemcitabine yielded notable pro-apoptotic effects in MIA-PaCa-2 cells with which ketogenic conditions had a synergistic effect that can hold promise for improving therapeutic options.Graphical

Study of electrocatalytic CO2 reduction using tin-oxalate organometallic frameworks doped with cadmium

The electrochemical reduction of CO2 demands highly effective catalysts due to the molecule’s inherent stability. Depending on the catalyst’s performance and selectivity, a range of products can be generated, from...

Inhibitory effect of organometallic framework composite nanomaterial ZIF8@ZIF67 on different pathogenic microorganisms of silkworms

Inhibitory effect of organometallic framework composite nanomaterial ZIF8@ZIF67 on different pathogenic microorganisms of silkworms

Enhanced Electrochemical Detection of Valganciclovir Using a Hierarchically Structured Lisianthus Flower-Inspired Bimetallic Ni-Ce Organic Framework.

This study reports the development of an innovative electrochemical sensor based on organometallic framework nanostructures for detecting valganciclovir (VLCV). VLCV is employed in the treatment of cytomegalovirus retinitis in AIDS patients. Rational design of nanoarchitectures for electroactive materials is a crucial approach for boosting their electrocatalytic performance. Herein, Lisianthus flower-inspired Ni-Ce-metal-organic framework (MOF), Ni-MOF, and rod-inspired Ce-MOF were synthesized by the solvothermal method. An electrochemical sensor for VLCV was developed by employing a multilayer approach using Lisianthus flower-inspired Ni-Ce metal-organic framework/multiwall carbon nanotubes (Ni-Ce-MOF/MWCNTs) modification on a glassy carbon electrode (GCE). Incorporating a bimetallic Ni-Ce-MOF into a conventional conductive material, such as MWCNTs, significantly increases the specific surface area and improves the conductivity and catalytic properties of the MWCNTs. Relative to the rod-inspired Ce-MOF and Ni-MOF, the electrocatalytic performance of the Lisianthus flower-inspired Ni-Ce-MOF coated on MWCNTs surpasses that of the rod-inspired Ce-MOF, showcasing enhanced performance in VLCV oxidation. This superiority arises from their enhanced electrical conductivity and enlarged surface area. The Lisianthus flower-inspired Ni-Ce-MOF/MWCNTs/GCE demonstrated extensive linear ranges (ranging from 4.0 to 3800.0 nM), a lower detection limit (1.4 nM), remarkable selectivity, and sustained stability over an extended period in the context of VLCV sensing. The real samples underwent analysis through using both electrochemical and UV-vis spectrophotometry methods, and the findings from both methods exhibited no substantial difference, validating the sensor's remarkable practical performance. These results suggest that Lisianthus flower-inspired Ni-Ce-MOF/MWCNTs/GCE electrocatalysts provide a promising sensing platform for analyzing biological samples.

2-Dimensional Palladium Organometallic Framework Generated Via C-H Activation for Electrochemical Syngas Production from CO2

Noble metal catalysts have been recognized for their exceptional catalytic activity and efficiency, sparking extensive research efforts. Recently, there has been a notable shift towards utilizing noble metal catalysts supported on stable materials, particularly within the realm of heterogeneous catalysts. Metal-Organic Frameworks (MOFs) have emerged as promising candidates in this regard, offering versatile platforms that serve as porous substrates for dispersing external noble metal species. Various methodologies have been developed to fabricate MOF-based noble metal catalysts, including the introduction of metal nanoparticles, the anchorage of metalloligands, and the utilization of desired metal clusters within the framework. However, because MOFs require metals to form their structures, the introduction of metal nanoparticles and the use of metalloligands necessarily entails the use of undesired metals. Therefore, while it is attractive to synthesize MOFs composed only of desired noble metals, direct synthesis of noble metal-based MOFs has been rarely reported due to significant synthetic challenges arising from the self-assembly of noble metal nanoparticles during solvothermal reactions.Considering the chemical softness of noble metals, expanding the range of metal–ligand bonds to include chemical soft bonds is crucial for diversifying linkages and incorporating metal atoms as low-valent metal ions and noble metals. Beyond traditional metal–oxygen and metal–nitrogen bonds with carboxylates and azolates, organometallic metal–carbon (M–C) bond connecting crystalline frameworks has gained attention. However, due to the scarcity of multivalent ligands for the M–C bond, generating organometallic frameworks with a single organic linker presents synthetic challenges.Herein, we found a new synthetic strategy applying organometallic chemistry. We successfully synthesized a Pd organometallic framework, PdOF-1, with a terephthalic acid (H2bdc), one of the most common ligands used for MOFs. PdOF-1 crystals were obtained through a one-pot solvothermal reaction of Pd acetate and H2bdc in dimethyl sulfoxide. Via Pd-catalyzed ortho C–H activation directed by carboxylic acid, Pd–C bonds were formed which directly connected bdc and Pd atoms. The framework comprises atomically dispersed Pd atoms forming organometallic Pd–C bonds, constituting a 2D network with the C2/c space group. As a result, PdOF-1 showed electrochemical CO2 reduction to produce syngas (H2/CO = 0.98) at a low potential of −0.33 V vs. RHE. This work not only presents a rare Pd organometallic framework, but also suggests a synthetic strategy to synthesize noble metal networks with M–C bonds and atomically dispersed noble metals.

A Convenient Approach for the Synthesis of Multidentate N-Heterocyclic Carbene Ligand Precursors.

Multidentate bis-NHCs ligands with various spacers are expected to combine the advantages of coordination chemistry and catalysis. These offer opportunities to construct various organometallic frameworks involving transition metals and main group elements. Therefore, developing a general procedure for synthesizing a variety of carbene salt precursors using a convenient technique is key in this context. The extended protocol of a solvent-free approach for synthesizing various bridged bis-imidazolium carbene salts, including tris and tetrakis-imidazolium precursors, is reported here. This method can be performed in the laboratory, leading to high yields (80-95 %) and isolated as analytically pure, multigram, bench-stable compounds.

New Materials for Thin-Film Solid-Phase Microextraction (TF-SPME) and Their Use for Isolation and Preconcentration of Selected Compounds from Aqueous, Biological and Food Matrices.

Determination of a broad spectrum of analytes, carried out with analytical instruments in samples with complex matrices, including environmental, biological, and food samples, involves the development of new and selective sorption phases used in microextraction techniques that allow their isolation from the matrix. SPME solid-phase microextraction is compatible with green analytical chemistry among the sample preparation techniques, as it reduces the use of toxic organic solvents to the minimum necessary. Over the past two decades, it has undergone impressive progress, resulting in the development of the thin-film solid-phase microextraction technique, TF-SPME (the thin-film solid-phase microextraction), which is characterized by a much larger surface area of the sorption phase compared to that of the SPME fiber. TF-SPME devices, in the form of a mostly rectangular metal or polymer substrate onto which a thin film of sorption phase is applied, are characterized, among others, by a higher sorption capacity. In comparison with microextraction carried out on SPME fiber, they enable faster microextraction of analytes. The active phase on which analyte sorption occurs can be applied to the substrate through techniques such as dip coating, spin coating, electrospinning, rod coating, and spray coating. The dynamic development of materials chemistry makes it possible to use increasingly advanced materials as selective sorption phases in the TF-SPME technique: polymers, conducting polymers, molecularly imprinted polymers, organometallic frameworks, carbon nanomaterials, aptamers, polymeric ionic liquids, and deep eutectic solvents. Therefore, TF-SPME has been successfully used to prepare analytical samples to determine a broad spectrum of analytes in sample matrices: environmental, biological, and food. The work will be a review of the above-mentioned issues.

Application and Optimization of Novel Asymmetric Catalysts in Drug Synthesis

This study aims to develop a novel asymmetric catalyst and explore its application and optimization in drug synthesis. By designing specific organometallic frameworks and optimizing the catalytic active centers, the study successfully enhanced the efficiency and selectivity of drug synthesis. The experiments included measuring catalytic efficiency, evaluating product selectivity, and testing the recyclability of the catalyst. The results indicate that the novel catalyst not only excels in improving synthesis efficiency but also demonstrates excellent selectivity and high potential for reuse. The study also investigates various factors affecting catalyst performance and provides constructive suggestions for future research directions.

Developments and Applications of Molecularly Imprinted Polymer-Based In-Tube Solid Phase Microextraction Technique for Efficient Sample Preparation.

Despite advancements in the sensitivity and performance of analytical instruments, sample preparation remains a bottleneck in the analytical process. Currently, solid-phase extraction is more widely used than traditional organic solvent extraction due to its ease of use and lower solvent requirements. Moreover, various microextraction techniques such as micro solid-phase extraction, dispersive micro solid-phase extraction, solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and magnetic bead extraction have been developed to minimize sample size, reduce solvent usage, and enable automation. Among these, in-tube solid-phase microextraction (IT-SPME) using capillaries as extraction devices has gained attention as an advanced "green extraction technique" that combines miniaturization, on-line automation, and reduced solvent consumption. Capillary tubes in IT-SPME are categorized into configurations: inner-wall-coated, particle-packed, fiber-packed, and rod monolith, operating either in a draw/eject system or a flow-through system. Additionally, the developments of novel adsorbents such as monoliths, ionic liquids, restricted-access materials, molecularly imprinted polymers (MIPs), graphene, carbon nanotubes, inorganic nanoparticles, and organometallic frameworks have improved extraction efficiency and selectivity. MIPs, in particular, are stable, custom-made polymers with molecular recognition capabilities formed during synthesis, making them exceptional "smart adsorbents" for selective sample preparation. The MIP fabrication process involves three main stages: pre-arrangement for recognition capability, polymerization, and template removal. After forming the template-monomer complex, polymerization creates a polymer network where the template molecules are anchored, and the final step involves removing the template to produce an MIP with cavities complementary to the template molecules. This review is the first paper to focus on advanced MIP-based IT-SPME, which integrates the selectivity of MIPs into efficient IT-SPME, and summarizes its recent developments and applications.

Janus Separation-Sensing Membrane Hosted with Enzyme@MOF Nanoreactor for Real-Time Blood Sensing.

Plasma separation, rich in biomarkers crucial for diagnosis, is conventionally achieved via high-speed centrifugation, a method hindered by its blood usage, lengthy processes, and complex operations, which delays detection. We introduced a novel real-time blood sensing method based on a Janus membrane and enzymes @MOFs. Asymmetric driving of the janus membrane can realize spontaneous separation of plasma and prevent hemolysis during direct separation. Glucose oxidase (GOx), uric acid oxidase (UOx) and horseradish peroxidase (HRP) were encapsulated in a hydrophilic organometallic framework (MOFs) to construct an enzyme cascade nanoreactor. Embedding enzyme in hydrophilic MOFs not only retains the natural conformation of free enzyme but also improves the brittleness of enzyme, endows MOFs with new biological functions, and expands its sensing application. Using 3,3',5,5'-tetramethylbenzidine (TMB) as a chromogen and a custom app for color interpretation, we achieved real-time visualization of glucose (Glu) and uric acid (UA) at a 50 μM limit. The system accurately analyzed serum samples, matching commercial kits and showing promise for portable, personalized diagnostics.

Graphene oxide enhanced the photocatalytic performance of one-dimensional porous carbon/ZnO hybrids

In order to improve the dispersion and photocatalytic performance of ZnO particles, one-dimensional graphene oxide/ZnO/carbon (GOZC) hybrid was prepared in situ by calcining zinc-based organometallic frameworks (Zn-MOFs) under nitrogen condition, and the structure and photocatalytic performance of the resultant GOZC were analyzed. The experimental results showed that one-dimensional corn-like ZnO/carbon (ZC) hybrid composed of porous carbon and ZnO nanoparticles was synthesized by carbonization, and GO was embedded in one-dimensional ZC hybrid with porous structure. The photocatalytic property of ZC material was improved by GO significantly, which the degradation rate of GOZC was 1.75 times higher than that of one-dimensional corn-like ZC. The enhancement for photocatalytic property originates that the incorporation of GO composites effectively reduces resistance and accelerates the separation of excited electron-hole pairs. This will provide an effective method for the preparation of porous carbon/metal oxides, and the resultant products possess very broad applications in the photoelectric materials, fuel cells, absorbing materials, ultraviolet light detectors, and piezoelectric materials.

Synergistic Innovations: Organometallic Frameworks on Graphene Oxide for Sustainable Eco-Energy Solutions

Combining organometallic frameworks with graphene oxide presents a fresh strategy to enhance the electrochemical capabilities of supercapacitors, contributing to the advancement of sustainable energy solutions. Continued refinement of materials and device design holds promise for broader applications across energy storage and conversion systems. This featured application underscores the inventive utilization of organometallic frameworks on graphene oxide, shedding light on the creation of superior energy storage devices for eco-friendly solutions. This review article delves into the synergistic advancements resulting from the fusion of organometallic frameworks with graphene oxide, offering a thorough exploration of their utility in sustainable eco-energy solutions. This review encompasses various facets, including synthesis methodologies, amplified catalytic performances, and structural elucidations. Through collaborative efforts, notable progressions in photocatalysis, photovoltaics, and energy storage are showcased, illustrating the transformative potential of these hybrids in reshaping solar energy conversion and storage technologies. Moreover, the environmentally conscious features of organometallic–graphene oxide hybrids are underscored through their contributions to environmental remediation, addressing challenges in pollutant elimination, water purification, and air quality enhancement. The intricate structural characteristics of these hybrids are expounded upon to highlight their role in tailoring material properties for specific eco-energy applications. Despite promising advancements, challenges such as scalability and stability are candidly addressed, offering a pragmatic view of the current research landscape. The manuscript concludes by providing insights into prospective research avenues, guiding the scientific community towards surmounting hurdles and fully leveraging the potential of organometallic–graphene oxide hybrids for a sustainable and energy-efficient future.

Boosted peroxymonosulfate activation by bimetallic organometallic frameworks via by-produced and dominated H2O2 generation

Verifying the role of H2O2 is a critical challenge for deepening the understanding of the mechanism of peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs). In this research, Co, Fe bimetallic organometallic frameworks (ZIF-L@Fe28) were prepared, and their ultrahigh activities via H2O2 generation at Fe and Co sites were experimentally and theoretically verified. The important contribution of H2O2 to 1O2 production was identified through the quantifications of the mutual transformation of active species. Co sites were identified as the most active positions for PMS activation because of they strongly triggered 1O2, SO4·−, ⋅O2−, ·OH, and H2O2. However, the self-quenching of active species suppressed the efficiency and selectivity of 1O2 generation at Co sites. In contrast to Co sites, Fe sites had selective preference for H2O2 generation, and the transformation of H2O2 to 1O2 further enhanced the performance of ZIF-L@Fe28. The supplementary discussion from the perspective of H2O2 will enable the further application of the PMS activation mechanism.

Density Functional Study of Electrocatalytic Carbon Dioxide Reduction in Fourth-Period Transition Metal-Tetrahydroxyquinone Organic Framework.

This study investigates the utilisation of organometallic network frameworks composed of fourth-period transition metals and tetrahydroxyquinone (THQ) in electrocatalytic CO2 reduction. Density functional theory (DFT) calculations were employed in analysing binding energies, as well as the stabilities of metal atoms within the THQ frameworks, for transition metal TM-THQs ranging from Y to Cd. The findings demonstrate how metal atoms could be effectively dispersed and held within the THQ frameworks due to sufficiently high binding energies. Most TM-THQ frameworks exhibited favourable selectivity towards CO2 reduction, except for Tc and Ru, which experienced competition from hydrogen evolution reaction (HER) and required solution environments with pH values greater than 5.716 and 8.819, respectively, to exhibit CO2RR selectivity. Notably, the primary product of Y, Ag, and Cd was HCOOH; Mo produced HCHO; Pd yielded CO; and Zr, Nb, Tc, Ru, and Rh predominantly generated CH4. Among the studied frameworks, Zr-THQ displayed values of 1.212 V and 1.043 V, corresponding to the highest limiting potential and overpotential, respectively, while other metal-organic frameworks displayed relatively low ranges of overpotentials from 0.179 V to 0.949 V. Consequently, it is predicted that the TM-THQ framework constructed using a fourth-period transition metal and tetrahydroxyquinone exhibits robust electrocatalytic reduction of CO2 catalytic activity.

Insights into the hexamine-assisted ZnO based-MOFs formation on PET fabric for improved self-cleaning, flame retardant, and hydrophilic properties

Organo-metallic frameworks (MOFs) have attracted much attention in the last decade due to their large pore size, large surface area, selective adsorption of small molecules, and optical or magnetic responses in the presence of guest molecules. Particularly, the use of MOFs on textile products through in situ synthesis leads to special properties in a simple method. Here, the polyester fabric was first activated by alkali hydrolysis and then the ZnO-based MOFs were synthesized to obtain a fabric with multifunctional features. FESEM images and EDX elemental analysis showed the presence of MOF particles and zinc, nitrogen, and hydrogen on the polyester surface. The weight of the treated samples increased however the water spreading time decreased due to the polar groups of the MOFs creating higher hydrophilic properties. The presence of hydroxyl and amine groups on the surface of the MOFs-treated polyester was confirmed by FTIR spectroscopy. The final fabric showed photocatalytic self-cleaning, and UV protection properties. In addition, TGA, ash percentage, and burnt length results demonstrated the flame-retardant properties. The tensile strength, thickness, and stiffness of the MOFs-treated fabrics also increased. Finally, the hexamine-assisted ZnO-based MOFs on the polyester surface improve its properties and usability.

Enhancing copper recycling through synergistic valence conversions in MnOx-modified capacitive deionization electrodes

The copper present in industrial waste has significant value for environmental resource recovery. Nonetheless, in electrosorption employed for ion separation, electrode materials commonly exhibit limited adsorption capacities, inadequate cycling stabilities, and insufficient selectivities toward specific ions for their single adsorption mechanism. In this study, a strategy was developed for optimizing the design of electrode materials to substitute zirconium atoms in organometallic frameworks (UiO-66, abbreviated as ZO) for manganese atoms from manganese oxide precursors to form a robust three-dimensional conductive structure (MZO). MZO has a stable and sizable adsorption region for electric adsorption, and manganese atoms with a dot-like dispersion provide Faraday active sites. Notably, in an external power supply circuit, Mn3+ fluently transforms to Mn2+ and then facilitates the deposition of copper ions by capturing electrons from Mn2+. Manganese regains electrons by utilizing the power source, which facilitates the continuous transfer of electrons to copper ions, enhancing the pseudocapacitance process. The combined effects of electrodeposition, a double-layer reaction, and a pseudocapacitive reaction improve the adsorption performance of MZO for copper ions, with an adsorption capacity of 249.5 mg·g−1 (at 1.2 V, 40 mg·L−1 Cu2+). Meanwhile, MZO based on ZO has acceptable cyclic stability, with a capacity retention rate of over 75 % after 32 cycles and 3 times of performance recovery experiments. Moreover, the MZO electrode exhibits positive selectivity for copper ions in mixed multiple salt solutions (separation factor α = 0.68). Density functional theory (DFT) calculations confirmed the selectivity of the MZO electrode for Cu2+ by providing the lowest binding energy (−2.4065 eV) for Cu2+.

Multicolor fluorescent probe based on copper nanoclusters and organometallic frameworks for selective detection of aluminum ions

The development of rapid visual detection methods for heavy metal ions is significant for food safety and environmental protection. This work integrated copper nanoclusters and the organometallic framework ZrMOF into a nano detection system. The blue fluorescence of ZrMOF was used as a fluorescent internal standard. The visual and rapid detection of aluminum ions (Al3+) was achieved by Al3+ induced fluorescence enhancement of copper nanocluster aggregates. This nanoprobe has the advantages of high sensitivity, rapid response, and high visualization. The nanoprobe can detect Al3+ with a concentration of 0–60 μM (LOD was 139 nM) and can be used to detect Al3+ in environmental water samples. In addition, an instant detection platform for test paper and gel system based on the nanoprobe was constructed by using the smartphone's colorimetric acquisition and computational analysis application software (APP), which guides the application of multicolor fluorescent nanoprobes in the intelligent detection of fruit surfaces and flour additives.

Нитрат 4,4’-дипиридил меди(II) – 2D металл-органический каркас

The crystal structure of the organometallic framework, namely, 4,4’-dipyridylcopper(II) nitrate with the DMSO molecule in the copper coordination sphere, has been described, the structural features have been established by the X-ray method. Crystallographic data: C55H93Cu2N12O23S7, М 1641.91; monoclinic syngony, space group P 1 21/n 1; cell parameters: a = 15.490(3), b = 14.760(3), c = 15.980(3); a = 90, β = 90.10(3), g = 90 deg.; V = 3653.5(13) Å3, Z = 2, ρcalc = 1.493 g/cm3. The bidental ligand in the organometallic framework is 4,4’-bipyridyl; copper, being a complexing ion, forms a coordination octahedron, the nitrogen atoms of bipyridine fragments are in four equatorial positions, the oxygen atoms of nitrate ion and dimethyl sulfoxide are in two axial positions. The Cu–N bond lengths in the equatorial position are in the range of 2.014–2.031 Å, and the Cu–O bond lengths are 2.297 Å and 2.515 Å. The occupation of the equatorial positions by 4,4’-dipyridyl leads to formation of a layered structure, which distinguishes the resulting compound from another MOF based on copper(II), nitrate ions and 4,4’-dipyridyl, in which all the equatorial positions are occupied by NO3-groups. The individual layers in the obtained 4,4’-dipyridylcopper(II) nitrate are not crosslinked; they are shifted relative to neighboring layers. The pyridyl rings of 4,4’-dipyridyl are rotated at an angle of 5.77(2) degrees. relative to each other.