The organocatalytic asymmetric domino process is a veryattractive method because of its ability to construct complexchiral molecules from readily available substrates under mildreaction conditions in two or more steps in a single operation.These reactions can save the time and the chemicals usuallyrequired for isolation or purification of the synthetic inter-mediates.Inaddition,noconcernformetalcontamination of the products is necessarybecause organocatalysts do not containtoxic or expensive metals. Examples oforganocatalytic asymmetric domino reac-tions mediated by chiral secondaryamines