Organization Project Research Articles

Reorganization of Waste Management Scheme for Construction and Demolition

The subject of the study is the organization of waste management of construction and demolition in the context of large-scale urban programs for new construction and renovation. This work is aimed at analyzing the principles of organizing the processing of construction waste and forming a proposal for the modernization of functional and planning schemes for handling construction and demolition waste in the context of large-scale urban programs for new construction and renovation. The following materials and methods were used: normative and technical documentation, construction organization projects, a list of environmental protection measures developed as part of the project documentation of implemented capital construction projects; additive scientometric analysis, generalization and presentation of aggregate experimental data on aspects of waste management of construction and demolition. The analysis of the principles of organization of processing of construction waste is performed. The functional and planning scheme of a stationary unit for processing construction and demolition waste and creating (producing) finished products with the integration of construction waste to create materials and products for new construction and renovation is proposed. The future use of the proposed functional and planning schemes is focused on making correct organizational and technological decisions when preparing organizational and technological documentation for capital construction projects. The development and implementation of economically and technologically sound management schemes for construction waste plays a relevant role in achieving responsible consumption and production, as well as in ensuring the transition to rational management models.

Economical Aspects of the Cost Regulation for the Construction of Buildings

The management of organization projects becomes specially actual, when there are formed in Russia the conditions of wide use of the project management methodology. The method given is an effective management tool in real Russian conditions in the same time is a tried mean of realization of organizational projects of the necessary quality, in the fixed time, within the limit of accepted budget. The project cost is defined by the combination of costs of project resources, by costs and time of execution of works of the project. For the construction projects the cost of construction is defined, which represents the part of project cost, that includes money, necessary for the capital construction. The calculation of all expenses on the project is equivalent to the general project cost. The management of project cost includes processes, necessary for the provision and guarantee of the accomplishment of project in the limits of affirmed budget. In the context of this paper cost management and expenses management are practically the same terms.

Risk Management in the Design of the Organization and Technology for the Construction of Buried Structures in Conditions of Compacted Development

The article substantiates the feasibility of developing and implementing a risk management plan for the implementation of construction projects in the conditions of compacted construction on the basis of risk identification at the stages of development of projects of organization and construction technology. The risk management algorithm is given. Design of construction of structures in conditions of compacted development usually requires consideration of many factors (risks) that affect the safety and quality of construction, but, as a rule, the most significant risks arise in the construction of the deepened part of the structure - "zero cycle". With this in mind, a Risk Management Plan for the construction of the "zero cycle" is proposed and emphasis is placed on the need to develop a strategy for the protection of the surrounding area and buildings. The conditions for achieving optimal efficiency of the Risk Management Plan are determined.

Assessment of Applying Global Instruments in Nongovernmental Organizations for Environmental Security and Sustainable Development in Developing Countries

Background. Environmental challenges are overwhelming the global communities. Thus, the purpose of the study is to explore how instruments used by the nongovernmental organizations are applied for environmental security and sustainable development in Ethiopia. It addresses issues of how environmental education in context is working to instill the knowledge, skills, awareness, and attitudes of the stakeholders. Recent discussions of the African Union Summit 2020, Africa Agenda 2063, Davos 2020 World Economic Forum, United Nations Agenda 2030, and the Green Economy Strategy in Ethiopia have strongly sought to strengthen environmental education as an instrument of global and local sustainability of the environment and development. Here, the study collected pieces of evidence from environmental programs of a nongovernmental organization in Ethiopia. The study focused on a nonformal environmental education, based on the frameworks of the agreements and declarations where Ethiopia is a contracting party. The frameworks are guiding concepts to investigate the phenomenon. Methods. The study used a thematic analysis based on empirical studies. Specifically, empirical studies from primary and secondary sources on the implementation of environment and forest development programs of the organization are crucial to providing a concrete presentation. Results. Empirical pieces of evidence show that the organization plans, projects, and performance reports were found inconsistent with the frameworks of international agreements and national policy. The empirical study also shows that environmental education is not well considered and institutionalized in the organization's project planning. Environmental education strategies are not explicitly visible while planning the projects. Moreover, in some implementation strategies of the organization, there was inconsistency in using environmental education as a strategic instrument to improve environmental security and quality. Conclusion. The organization's environmental performance was deep-rooted to improve the status quo in the living community. However, the utilization of environmental education was discovered to be minimal. Thus, stakeholders and the organization take the advice to integrate into the entire cycle of the project.

The effectiveness mechanisms to reduce poverty rate and improving the standard of living – A case study of South Darfur state –: فعالية الآليات المتبعة لخفض معدل الفقر وتحسين مستوى المعيشة – دراسة حالة ولاية جنوب دارفور –

The study aimed to identify the effectiveness of the mechanisms used to reduce the Poverty rate and improving the standard of living in the area of the study. Descriptive Analytical method was used. The primary data has been collected by using a questionnaire as the main tool of data collection from poor who have given projects during the period of study. A random sample consists of sixty persons was selected. The study concluded to the many results, the most important one is the effective role of the tools in reducing poverty in the state has been realized due to the analysis proved by Chi-Square indication of 0.05 reflected that there is an inverse relationship having a positive impact statistically between the projects of Zakat Chamber, microfinance and voluntary organizations and bettering livelihoods level in the state. The study recommended that the necessity for Zakat Chamber, microfinance and voluntary organizations to supervise and follow up the projects that given to poor in order to sustain their successfulness.

Lessons to Be Learned from Ukraine’s Positioning in International Rankings: The Need for Institutional Support and Financial Support for Economic Creativity

Purpose: To develop proposals on the directions of institutional support for the processes of creativity of the Ukrainian economy. Design/methodology/approach: The analysis of trends in the creativity of the Ukrainian economy is carried out and proposals are developed for conceptualizing institutional support for these processes. The authors set out to develop proposals for institutional support for creativity processes and offer recommendations for systematic updating of Ukrainian legislation in the areas of state regulation of high-tech business. The information base was the information materials of the State Statistics Service of Ukraine, Ministry of Economic Development and Trade of Ukraine, the statistical databases of the European Commission, OECD and World Bank for the period 2014–2020. The research methodology is based on scientific tools that include comparative analysis and economic and mathematical modeling. Findings: Building a national program of public investment in creative development will allow us to systematically approach the issue of institutional support for technological breakthroughs. Research limitations/implications: Recommendations on the development and improvement of legislative instruments of deregulatory policy, harmonization with European standards are substantiated. Directions of systematic updating of legislation on guaranteeing foreign investment of creative projects and targeted investment of joint research projects of academic science and creative organizations are proposed. The implementation will allow a systematic approach to the issue of institutional support for the technological breakthrough of Ukraine. Originality/value: There is a need to step up institutional activities in the field of organizing research centers, introduce targeted investment in the academic science and research activity of creative organizations.

Separating Church and Market: The Duty to Secure Market Citizenship for All

This Article intervenes in the debate concerning the conflict between religious liberties and LGBTQ rights. Strictly focusing on the market, it makes three salient contributions. First, it reveals the appearance of a preemptive legal strategy that has started to generate unprecedented jurisprudence in lower courts. This latest shift is the peak of an ecopolitical practice called “market evangelism,” which the Article defines as the organized project that uses market activities, entities, and tools to evangelize society by excluding LGBTQ parties from the marketplace. Second, the Article adds to the current argument regarding the harm that market evangelism inflicts. It depicts the recent concerted efforts to conceal the damage and explains market evangelism as an intentional effort to humiliate LGBTQ people, causing intense and enduring harm that spreads from LGBTQ individuals to their entire community. Third, the Article proposes an original resolution particularly tailored to the market. It argues that business activity that relies on corporations and contracts must include an attached obligation to serve all; this is the price of what the Article conceptualizes as market citizenship. Significantly, the proposal goes beyond adding strong arguments for the necessary passing of the Equality Act. It further includes a novel call to utilize private law, namely corporate law and contract law, to bar market evangelism and secure a market open for all.

The Forerunners of Libertarian Pedagogy (18. and 19. Centuries): A Gallery of Forgotten Portraits of Women

The article deals with the historical and philosophical foundations of libertarian pedagogy as a project of non-hierarchical organization of educational, cognitive and learning processes. It focuses on pedagogical concepts that have had a decisive influence on the modern face of libertarian pedagogy, but are poorly represented in the mainstream pedagogical discourse and are not known in Russia at all. Since women are an absolute majority among the authors who have been displaced from the official pedagogical discourse, the article aims to identify their forgotten figures and to redefine the significance of their contribution both to a particular pedagogical tradition and to pedagogy as a whole. In the light of this fact we make an attempt of primary reception in Russian-speaking academic space of philosophical-pedagogical ideas of Enlighteners of 18th- 19th centuries that influenced modern libertarian-pedagogical discourse. This revision attempts to identify, compare, and evaluate from a modern perspective the main trends of their quests. The study is based both on the texts of key primary sources and a number of monographs and articles on the philosophy and history of education.

Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years

We celebrate the 10th anniversary of the launch of the HUPO Human Proteome Project (HPP) and its major milestone of confident detection of at least one protein from each of 90% of the predicted protein-coding genes, based on the output of the entire proteomics community. The Human Genome Project reached a similar decadal milestone 20 years ago. The HPP has engaged proteomics teams around the world, strongly influenced data-sharing, enhanced quality assurance, and issued stringent guidelines for claims of detecting previously “missing proteins.” This invited perspective complements papers on “A High-Stringency Blueprint of the Human Proteome” and “The Human Proteome Reaches a Major Milestone” in special issues of Nature Communications and Journal of Proteome Research, respectively, released in conjunction with the October 2020 virtual HUPO Congress and its celebration of the 10th anniversary of the HUPO HPP.

Фінансове забезпечення закладів фахової передвищої освіти: сутність, нормативні, організаційні та облікові аспекти

The article is aimed at studying the main features of institutions of professional pre-higher education (colleges) as structural subdivisions of higher educational institutions and the peculiarities of their financial provision, as well as developing proposals for its optimization and accounting display, including in the direction of development of sources that are viewed as a structural subsystem of the financial mechanism. As a result of the study, the need to optimize the financing of education and its further development is proved. On the example of institutions of professional pre-higher education, the problem of reducing the number of applicants for education and educational institutions is identified, which negatively affects the level of supplying the Ukrainian labor market with specialists. The connection of the level of financing with the State policy on the development of education in Ukraine and the use of a new budget mechanism in this area, which stipulates the transfer of a number of pre-higher educational institutions to financial provision from local budgets, is determined. A significant impact on the functioning of pre-higher education on the part of the adopted Law of Ukraine «On Pre-Higher Education» is identified, which, among other things, defines the possibility of not only budgetary support, but also funding at the expense of other sources that are not prohibited by law, with the obligatory observance of the principles of targeted and effective use of funds, publicity and transparency in decision-making. The authors examine the problems that have occurred in the system of professional pre-higher education and it is concluded about absence of a comprehensive, scientifically based program of financial provision for the activities of educational institutions, which would create a financial basis for the strategic development of pre-higher education in Ukraine in the context of globalization and informatization of society. In its development, it is proposed to take into account all possible sources of financing, as well as to improve the accounting system in the direction of separate display of its revenues in the context of relevant sources and to form a working plan of accounts accordingly. The expediency of applying such a form of financing of social projects and target programs of educational institutions as fundraising, which represents a specially organized process of gathering monetary means for the implementation of projects of non-profit organizations, is substantiated. Financial provision of colleges based on fundraising can be carried out using instruments such as grants or payment for services on a contractual basis. Innovations in financing affect their accounting, and this issue is currently under-researched. Therefore, research on the issues of improving both the synthetic and the analytical accounting of financial provision from various sources, as well as the development of a system of documentary support of fundraising relations between counterparties, are perspective.

Dietary Patterns for Health and Sustainability: From Experts’ Opinions to Action for the WHO European Region

Background: To reduce the negative impact of diets on human and planetary health, healthy and sustainable ones need to be adopted. Food systems account for a quarter of greenhouse gas emissions. ‘Dietary Patterns for Health and Sustainability’ is a World Health Organization project that aims to build consensus among international food, health, and sustainability experts and policymakers on actions and policies that could be implemented in the WHO European Region. Methods: Online interviews were conducted with 19 experts from European countries to elicit their views on multiple dimensions of food sustainability and health. Interviews were followed by a Nominal Group Technique and focus groups carried out during a participatory workshop with 32 experts. Findings: The aspects emphasised in the individual interviews and during the workshop were: the need for a multi-stakeholder approach and for simultaneous implementation of aligned and coherent policies at both local and regional levels; the call for a shift towards plant-based diets with a reduction in food waste; and the importance of adapting recommendations to each context (local, regional or national).Interpretation The study findings will be key to helping policymakers make decisions on improving dietary patterns for citizens’ health and wellbeing, in line with the European Programme of Work (EPW) and the Sustainable Development Goals in the European Region. Funding: This research was funded by the WHO Regional office for Europe. Funding for the publication was received from the Government of the Russian Federation within the context of the WHO European Office for the Prevention and Control of Noncommunicable Diseases (NCD Office). Declaration of Interest: The authors report no conflicts of interest.

Everyday built environments of care: Examining the socio-spatial relationalities of suburban neighbourhoods for people living with dementia

There has been a call from US policy advisors to expand research on people living with dementia (PLWD) from health and social sectors to urban planning. The World Health Organization projects the number of PLWD to increase from 47 to 132 million worldwide by 2050, with 60–80% of PLWD residing within the community (as opposed to congregate settings). For PLWD, being supported by their neighbourhoods in terms of access has many benefits: more social interaction, sense of worth, dignity, and improved physical/mental health. As PLWD are likely to experience a “shrinking world” effect, it is important to investigate the socio-spatial relationality between PLWD and their neighbourhoods. Using a relational care lens, this research seeks to understand the everyday practices of seven (7) PLWD in their suburban neighbourhoods using multiple methods (semi-structured and go-along interviews, GPS tracking, travel diaries). PLWD interact with their neighbourhoods through processes of caring for self in the past, present, and future, in addition to (re)organizing their newfound interdependent realities and being cared for through human and more-than-human encounters in public spaces. This research demonstrated the ways in which PLWD were living through adversity in the built environment (“hopeful adaptation”), revealing innovative practices and structural barriers in suburban areas. Being able to access one's neighbourhood is a right, and this research highlights how certain socio-spatial characteristics of suburban neighbourhoods can, through a relational care lens, become a simultaneously caring and careless place.

System approach to using information modelling technology in sustainable construction production development

The paper considers the possibility of studying the potential for the effectiveness of the economic and visual model and reducing operating costs in the development of construction facilities. Methods of visual modelling are presented, which make it possible to effectively implement construction organization projects. The economic and visual model contributes to the formation of the element base of rational economic, organizational and technological solutions. The following methods were used: system analysis, logical-mathematical modelling, systems theory, economic and visual modelling, research methods of operations, economic and mathematical methods. The modern experience of using the model has been studied. On the basis of an analytical review regarding economic and visual modelling, the works of domestic and foreign authors are studied. The element base of the optimal solution of organizational and technological processes is formed on the basis of the information model (BIM). The conducted analytical review of the study of materials on the practical application of the economic and visual model on the territory of the Russian Federation based on the results of the theoretical study confirms that there is no alternative to improving the formation of new information systems for modelling the organization of

EXPERIMENTAL STUDIES OF A MODEL FOR OPTIMIZING THE PORTFOLIO OF A PROJECT-ORIENTED ORGANIZATION BASED ON THE ENTROPY CONCEPT

The subject of the research is the optimization of the composition of the project portfolio based on the entropy concept. The aim of the study is to experimentally test the model for optimizing the portfolio of a project-oriented organization and substantiate its applicability in practice in management processes to ensure their effectiveness. Research objectives: forming a model taking into account the accepted value of the organization; formation of initial data on the organization and alternative projects; portfolio optimization by model and interpretation of results. Research methods: system analysis, functional analysis, operations research. Results. A model has been developed for forming a portfolio structure from projects of two categories – operational and development; the optimization criterion is to minimize the discrepancy between the desired and actually provided value of the organization. The restrictions take into account the maximum allowable energy limit and the minimum allowable value limit. As a result of the study, the applicability and adequacy of the model for optimizing the portfolio structure of a project-oriented organization were substantiated. The model makes it possible to obtain solutions on the optimal structure of a portfolio of projects in terms of its value under given resource constraints (in the form of a share of total energy and output energy) and energy entropy. The studies substantiated the possibility of adjusting the model in terms of the optimization criterion (maximizing value, minimizing energy entropy) and adding restrictions on the maximum permissible border of information entropy and energy efficiency. Conclusions. The model under consideration is characterized by wide practical application, taking into account its possible adjustment without changing the basic essence, taking into account the specifics of a particular field of activity or organization. The practical use of the main indicators of the entropy concept - information entropy, temperature, energy entropy, which characterize the state of organizations, allowing to identify hidden problems before they are reflected on the traditional indicators of organizational performance is demonstrated. Taking this into account, the structure of the project portfolio is being formed within the framework of the considered approach.

Combining the strength of centralized control and distributed autonomy for crowdsourcing design: An integrated model of Blackboard and Bayesian network

Socialized product design (SPD) mode, enabled by advanced internet technologies and sharing economic trends, has the capability of utilizing the design resources from large numbers of socialized designers (SDs) to carry out the design tasks that used to be participated by only the internal R&D staffs of companies. During SPD projects, different kinds of mechanisms can be applied to organize the SDs. Some of them tend to be centralized control (e.g. crowdsourcing design) and some are more of distributed autonomy (e.g. opensourcing design). Both centralized control and distributed autonomy have their strengths and limitations for SPD. Centralized control enables more organized, focused, and efficient project execution, but it limits the emergence of collective intelligence among the SDs. Distributed autonomy helps to explore the innovation potential of SDs by granting them the freedom of communication and mutual inspiration, but it may cause the problem of unreliable and unpredictable design process. To complement the advantages of centralized control and distributed autonomy in SPD, an integrated model of Blackboard and Bayesian network is established in this paper. The Blackboard, whose Control modules are specially customized for human Knowledge sources, is for guaranteeing overall control of the distributed design process and at the same time permitting certain level of autonomy to the SDs. The Bayesian network, built with an improved Bayesian causal map method, is an embedded Control module of the Blackboard which evaluates design solutions according to the incomplete collective judgments from SDs. The operability of the integrated model has been verified through a case study of 3D printer conceptual design project.

The Cure May Lie Within

With an estimated 14 million new cases and 8 million cancer-related deaths in 2012, the World Health Organization (WHO) projects that by 2035, the world could see 24 million new cancer cases and 14 million cancer-related deaths each year (Antoni et al., 2016). Cancer is undoubtedly a major global health issue.

THE STATE OF BROWN CARPATHIAN AND BROWN CAUCASIAN CATTLE BREEDS ON FAO PROJECT TCP/RER/3604 “CONSERVATION AND DEVELOPMENT OF DUAL-PURPOSE CATTLE BREEDS IN EASTERN EUROPE”

During 2018–2019 Ukraine took part in the project of Food and Agriculture Organization (FAO) «Conservation and development of double-purpose cattle breeds in Eastern Europe» (TCP/RER/3604). The project covered Brown Carpathian and Brown Caucasian breeds of Armenia, Georgia and Ukraine. On the results of the project, experts from the FAO Regional Office for Europe and Central Asia, international experts prepared reports on gender, social and economic characteristics of the studied regions, genomic analysis of samples and provided recommendations for breeding in the regions with the breeds. It was considered expedient to present these results to the general scientific community.
 At each country FAO have chosen service-provider (organization), which should make survey on productive environment of targeted breed (in Ukraine – Brown Carpathian), conclude the general state of the breed, visit at least 100 farms where Caucasian/Carpathian Brown cattle breed was kept, collect information from 300 cows and 20 bulls, and genetic samples from at least 100 cows and 20 bulls kept for breeding. Service-provider in Ukraine was M.V.Zubets Institute of Animal Breeding and Genetics, NAAS.
 Scientists of M.V.Zubets Institute of Animal Breeding and Genetics and other sub-contracting organizations during February-June, 2019 investigated 265 heads of cattle in 31 villages 5 districts of the Transcarpathian region, phenotypically classified as Brown Carpathian breed, including 6 breeding bulls of mating age (1.5–2 years). Each animal was photographed, linearly descriptive features of the exterior were evaluated, the necessary body measurements were taken with the help of appropriate tools, live weight and constitutional features were determined, and samples were taken for genetic testing.
 A total of 554 hair samples were taken from the project (123 – from Armenia, 141 – from Georgia and 290 – from Ukraine).
 The basis for classifying the animals as Brown Carpathian was phenotypic examination and strict compliance with the main characteristics of the breed: uniform grey or brown colour with different shades of it, general conformation typical for the breed, lighter belt along the back, black muzzle with lighter hair around it, black hooves and horn tips, lighter "glasses" around the eyes, thick light hair inside outer ears.
 To form the genetic passport of the population, hair was selected from the tail switch of selected animals using equipment provided by FAO, sent to the laboratories of the International Atomic Energy Agency, Austria. In the laboratory in the district of Siebersdorf, DNA was isolated from the obtained samples, the genetic diversity of populations, the degree of inbreeding and their effective number, kinship between populations were assessed and the genetic structure and level of influence of other breeds were analysed.
 DNA was extracted from each hair follicle using a MasterPure kit (Biozym, Illumina, USA) according to the protocol of the Association of Public Health Laboratories (APHL). The isolated DNA was subjected to a two-step quality control procedure before preparation for wide-genome typing. DNA samples were measured using a Nanodrop spectrophotometer to obtain a concentration with a ratio of 260/280 and 260/230. According to the results obtained using a spectrophotometer, DNA samples were diluted to measure high-quality double-stranded DNA (dsDNA) by PicoGreen Assay. The final working DNA was prepared based on PicoGreen measurements and stored at – 20°C for further processing.
 Sample genotyping was performed using a third-generation 384-cell matrix to assess Bovine individuals on the Affymetrix-Axiom platform (Axiom Bovine Genotyping v3 array). Within the project, 48 individuals of Austrian Simmental and 18 – Ayrshire breeds were also genotyped for comparison. The matrix included 64.000 SNPs, providing a high probability of covering genomic variations of the Bos taurus and Bos indicus breeds.
 Intra-breed genetic diversity was assessed using PLINK v1.09 to calculate actual heterozygosity (H0) and inbreeding coefficient (FIS).
 Analysis of genetic parameters of population diversity evidenced a rather low inbreeding rate of Brown Carpathian breed and a fairly high effective population size compared to European breeds, which can indicate a very limited practice of artificial insemination and lack of selection among bulls.
 Analysis of genetic differentiation and relationship between populations, principal components analysis and determination of admixtures of other breeds proved the uniqueness of the Brown Carpathian breed from a genetic point of view.
 Based on the conducted genomic analysis of populations, consultations with project participants, reports of service providers of each country, an international consultant on animal genetic resources, chairman of the ICAR working group on functional traits, formed a breeding program for the studied populations. The breeding program included proposals for further selection work, calculation of basic selection-genetic parameters, selection effect, number of bulls and heifers for selection nucleus, number of doses to maintain genetic diversity of the population, cost of population restoration, breeding work of breeding centre and work plan by years to implement a breeding program.
 Gender analysis of service providers' reports showed some gender differentiation in livestock care, processing and everyday life of owners of Brown Carpathian cattle.

Impact of the common MTHFR 677C\u2192T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

BackgroundGenome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the MTHFR co-factor) can lower blood pressure (BP) in hypertensive patients with the variant MTHFR 677TT genotype. We investigated the impact of this common polymorphism on BP throughout adulthood and hypothesised that riboflavin status would modulate the genetic risk of hypertension.MethodsObservational data on 6076 adults of 18–102 years were drawn from the Joint Irish Nutrigenomics Organisation project, comprising the Trinity-Ulster Department of Agriculture (TUDA; volunteer sample) and the National Adult Nutrition Survey (NANS; population-based sample) cohorts. Participants were recruited from the Republic of Ireland and Northern Ireland (UK) in 2008–2012 using standardised methods.ResultsThe variant MTHFR 677TT genotype was identified in 12% of adults. From 18 to 70 years, this genotype was associated with an increased risk of hypertension (i.e. systolic BP ≥ 140 and/or a diastolic BP ≥ 90 mmHg): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.07 to 1.90; P = 0.016, after adjustment for antihypertensive drug use and other significant factors, namely, age, male sex, BMI, alcohol and total cholesterol. Low or deficient biomarker status of riboflavin (observed in 30.2% and 30.0% of participants, respectively) exacerbated the genetic risk of hypertension, with a 3-fold increased risk for the TT genotype in combination with deficient riboflavin status (OR 3.00, 95% CI, 1.34–6.68; P = 0.007) relative to the CC genotype combined with normal riboflavin status. Up to 65 years, we observed poorer BP control rates on antihypertensive treatment in participants with the TT genotype (30%) compared to those without this variant, CT (37%) and CC (45%) genotypes (P < 0.027).ConclusionsThe MTHFR 677TT genotype is associated with higher BP independently of homocysteine and predisposes adults to an increased risk of hypertension and poorer BP control with antihypertensive treatment, whilst better riboflavin status is associated with a reduced genetic risk. Riboflavin intervention may thus offer a personalised approach to prevent the onset of hypertension in adults with the TT genotype; however, this requires confirmation in a randomised trial in non-hypertensive adults.

Analyzing Critical Factors: Motivating Project Managers

Abstract The concept of project management has evolved tremendously over the years. In addition to the technostructural changes that have taken place, the recent pandemic and sociocultural events and subsequent reflection that has occurred have impacted how people live and work. The purpose of this research study was to investigate the factors that create a culture of modern-day multigenerational project managers to be fully emotionally engaged when managing and leading organization projects. One hundred twenty practicing project managers working in a variety of industries representing different countries were interviewed. The findings identify the top six most frequently cited factors. The paper then explores ways to assist organizational leaders in design work environments that support modern-day multigenerational project managers to be fully emotionally engaged when managing and leading organization projects.

Por uma História Visual

Este artigo apresenta os resultados do projeto de organização e sistematização dos acervos e dos documentos do Laboratório de Pesquisa em História da Imagem e do Som (LPHIS), pertencente ao Programa de Pós-Graduação em História da PUCRS, que completa 23 anos de existência em 2020. Assim, busca-se apresentar sua trajetória ao longo desses anos, entendendo-o como um espaço de formação e fomento à pesquisa, assim como o contexto de criação do atual LPHIS em relação a de outros centros de pesquisa acadêmica em imagem e som.