Abstract
We celebrate the 10th anniversary of the launch of the HUPO Human Proteome Project (HPP) and its major milestone of confident detection of at least one protein from each of 90% of the predicted protein-coding genes, based on the output of the entire proteomics community. The Human Genome Project reached a similar decadal milestone 20 years ago. The HPP has engaged proteomics teams around the world, strongly influenced data-sharing, enhanced quality assurance, and issued stringent guidelines for claims of detecting previously “missing proteins.” This invited perspective complements papers on “A High-Stringency Blueprint of the Human Proteome” and “The Human Proteome Reaches a Major Milestone” in special issues of Nature Communications and Journal of Proteome Research, respectively, released in conjunction with the October 2020 virtual HUPO Congress and its celebration of the 10th anniversary of the HUPO HPP.
Highlights
The global Human Proteome Project is the flagship activity of the HUMAN PROTEOME ORGANIZATION (HUPO). HPP Guidelines for mass spectrometry (MS) Data have greatly enhanced confidence in proteomics data. The community has identified proteins from 90% of predicted protein-coding genes. A total of 1899 predicted proteins lack sufficient evidence of expression as of 2020
We celebrate the 10th anniversary of the launch of the HUPO Human Proteome Project (HPP) and its major milestone of confident detection of at least one protein from each of 90% of the predicted protein-coding genes, based on the output of the entire proteomics community
During the lifetimes of my contemporaries, we have learned that triplet-nucleotide sequences of double-helical DNA carry the code of heredity, that normal human cells have 46 chromosomes, and that proteins carry out an amazing variety of structural, metabolic, catalytic, immune, regulatory, and signaling functions
Summary
In Brief Starting from several organoriented projects, HUPO in 2010 launched the Human Proteome Project to identify and characterize the protein parts list and integrate proteomics into multiomics research. We celebrate the 10th anniversary of the launch of the HUPO Human Proteome Project (HPP) and its major milestone of confident detection of at least one protein from each of 90% of the predicted protein-coding genes, based on the output of the entire proteomics community. The Pathology pillar is dedicated to translation of proteomics and systems medicine to clinical applications in diagnosis and therapeutics Another significant feature of the HPP was the leading-edge experience and guidance of the Scientific Advisory Board of Michael Snyder (chair), Catherine Costello, Kun-liang Guan, Denis Hochstrasser, Leroy Hood, Matthias Mann, Kate Rosenbloom, Naoyuki Taniguchi, Mathias Uhlen, and John Yates; in 2020 Ruedi Aebersold became chair, with Subhra Chakraborty, Anne-Claude Gingras, Fuchu He, Kathryn Lilley, Emma Lundberg, Anthony Purcell, and John Yates. I had the privilege of chairing the HPP from 2010, followed by Mark Baker in 2018 and Rob Moritz in 2020
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