This study aims at evaluating the effect of organizational commitment on organizational spirituality and happiness among MBA expert managers south of Iran; it is a descriptive correlational study. This study evaluated 338 participants based on complete count method; participants were MBA expert managers south of Iran. Data were gathered applying Hall and Edwards, organizational commitment Questionnaire of Mowdy, Porter & Steers and Oxford Happiness Test. Data were analysed by multi-variable linear regression analysis by simultaneous method by SPSS22. Findings indicate that there is a positive relationship between organizational spirituality and its components with organizational commitment and its three aspects and there is a positive relationship between organizational spirituality, happiness and its dimensions. Among different Aspects of organizational spirituality, awareness, instability, perception management and magnification could predict organizational commitment, and awareness, true acceptance and helplessness could predict variable of business managers’ happiness.