Organization Database Research Articles

Global trends in esophageal cancer mortality with predictions to 2025, and in incidence by histotype

BackgroundEsophageal cancer (EC) is a malignancy with a poor prognosis. We provided a global overview of EC mortality, analyzing figures over the last three decades and estimating mortality rates for the year 2025. We also reported incidence trends and the distribution of squamous cell carcinoma (SCC) and adenocarcinoma (AC) in selected countries. MethodsWe considered EC trends in the age-standardised mortality rates (ASMR) from the World Health Organization database for selected countries. To estimate the number of deaths and ASMRs for 2025, we applied a Poisson linear regression model to the latest trend segment identified using a joinpoint model. We reported EC incidence trends according to histology using the Cancer Incidence in Five Continents database for the calendar period of 1990–2012. ResultsIn 2015–19, the male ASMRs/100,000 were 4.01 in the EU-27, 4.28 in the USA, and 5.10 in Japan. The corresponding female rates ranged from 0.82 to 0.85/100,000. Male mortality showed a decreasing trend in most countries analyzed, with earlier and steeper declines in southern Europe. Conversely, ASMRs were increasing in Belarus, Finland, Greece, and Cuba. Female mortality showed a slight increase in several European countries, while North America, Latin America, and Australasia showed favorable trends. Projections suggest that male EC mortality is expected to decline in all countries except the Russian Federation. Female favorable trends are also predicted in most countries, except for France, Germany, the Russian Federation, and Canada. SCC remained the most common histotype, but AC incidence showed an upward trend, particularly in high-income countries. ConclusionThe observed trends in EC mortality reflect variations in patterns of major risk factors. Effective control of risk factors would contribute to reducing the burden of EC, together with early diagnosis and potential improvements in treatments.

Optimization of the physical parameters of the organization of databases

The main task of the transport system is the most complete satisfaction of the needs of business entities and the population in transportation, reducing the time of delivery of goods and transportation of passengers on the basis of a qualitative increase in the capacity of the entire transport system. This problem is solved with the help of computer technology and new information technologies in transport management systems. The most demanded is the database technology implemented in modern automated transport management information systems.Given the exponential growth in the volume of databases used, strict time limits for real-time management decisions in transport management systems, the task of minimizing the time to execute information queries in the database is of particular relevance.The execution time of information requests is influenced by the methods of physical storage of databases. To solve the problem of minimizing the execution time of information requests, it is necessary to determine the physical parameters that affect the efficiency of database processing.An external memory simulation model is described for optimizing the physical parameters of database organization, based on the exchange procedures implemented in modern database management systems between external and operational memory upon information requests. As a key optimization parameter, a memory block reservation factor is substantiated, which allows minimizing the number of slow accesses to external memory.The rationality and adequacy of the proposed model in the process of research is confirmed by the results of simulation modeling.

The political economy of healthcare access and Chicagoland health-oriented non-profit organizations

This paper analyzes how nonprofit organizations targeting Latine communities in the Chicago suburbs played a role in healthcare access during the COVID-19 pandemic through both political and material actions. Using mixed methods, this research explores the organizational and political infrastructural differences between Chicago and Chicago suburban nonprofit community-based organizations (CBOs) as they responded to the COVID-19 crisis. Data was collected through both interviews with CBO organizers, and spatial analysis of a database of nonprofit organizations in the Chicagoland area. The findings advance the concept of the infrastructure of civic institutions through finding that distance and differences in funding and collaboration amongst CBOs significantly impact the access of CBOs to structural supports to then provide for their communities. This analysis also includes the comparison of two CBOs to illustrate these geographic differences in funding and collaboration. These findings help demonstrate the need for a more collaborative and versatile design of community-based work, which moves away from the traditional nonprofit funding structure.

Assessing Kidney Transplantation Using ECMO-Supported Donors Within a KDPI-Based Allocation System.

Organ donors supported by extracorporeal membrane oxygenation (ECMO) have historically been considered high-risk and are judiciously utilized. This study examines transplant outcomes using renal allografts from donors supported on ECMO for nondonation purposes. Retrospective review of the Gift of Life (Pennsylvania, New Jersey, Delaware) organ procurement organization database, cross-referenced to the Organ Procurement and Transplantation Network database, assessed kidney transplants using donors supported on venoarterial (VA) and venovenous (VV) ECMO for nondonation purposes. Transplants using VA- and VV-ECMO donors were compared with Kidney Donor Profile Index (KDPI)-stratified non-ECMO donors. Regression modeling of the entire ECMO and non-ECMO populations assessed ECMO as predictive of graft survival. Additional regression of the ECMO population alone assessed for donor features associated with graft survival. Seventy-eight ECMO donors yielded 128 kidney transplants (VA: 80, VV: 48). Comparing outcomes using these donors to kidney transplants using organs from KDPI-stratified non-ECMO donors, VA- and VV-ECMO donor grafts conferred similar rates of delayed graft function and posttransplant renal function to KDPI-matched non-ECMO counterparts. VA-ECMO kidneys demonstrated superior graft survival compared with the lowest-quality (KDPI 86%-100%) non-ECMO kidneys and similar graft survival to KDPI <85% non-ECMO kidneys. VV-ECMO showed inferior graft survival to all but the lowest-quality (KDPI 86%-100%) non-ECMO kidneys. VV-ECMO, but not VA-ECMO, was associated with increased risk of graft loss on multivariable regression (hazard ratios-VA: 1.02, VV: 2.18). Higher KDPI, advanced age, increased body mass index, hypertension, and diabetes were identified as high-risk features of ECMO donors. Kidney transplantation using appropriately selected ECMO donors can safely expand the donor pool. Ongoing studies are necessary to determine best practice patterns using kidneys from these donors.

First Report of Anthracnose on Dioscorea opposita Caused by Colletotrichum siamense in Guangdong province in China.

Yam is the world's fourth most important tuber crop, after cassava, potato, and sweet potato in the world, the cultivation area of yam from the Food and Agriculture Organization of the United Nations Statistics Division database (FAOSTAT) is about 8,831,037 ha in 2020. Chinese yam (Dioscorea opposita Thunb.) is an economically important root crop throughout China due to its high economic and medicinal value. South China including Guangdong and Guangxi provinces is one of the important production districts of Chinese yam with economic value. A disease affecting the leaves was observed on yam leaves in August 2021 with an incidence of 20 to 90% in Guangdong and Guangxi provinces. Symptoms start as pinpoint lesions on yam leaves which enlarged to oval spots and large irregular spots. The spots were brown and surrounded by a chlorotic halo with sunken cavities, which are typical symptoms of anthracnose. To identify the causal agent, 9 symptomatic leaves from 3 different districts were collected in Guangdong and Guangxi provinces. Leaf samples were disinfested with 1% NaOCl for 3 min, and cultured on potato dextrose agar (PDA) at 28 °C for 3 days week. 9 single-spore isolates were recovered from each PDA medium. Colonies on PDA were grayish white with bright orange conidial spore masses. Fungal mycelia were hyaline, septate, and branched. Conidia were born on a long conidiogenous cell, straight, hyaline and cylindrical with rounded ends, 5.3 to 6.8×15.2 to 21.3μm (n = 50). Appressoria were dark, smooth-walled, oval in shape. The isolates were morphologically identified as Colletotrichum sp. (Weir et al. 2012). 3 strains were used for the pathogenicity test, 5 plants at creeping stage were inoculated with each isolate separately and 3-5 leaves of each plant were inoculated. Fresh wounds were made with a sterile needle on the healthy surface of yam leaves and each leaf was covered with a piece of cotton drenched with conidial suspension (106 conidia/mL) from each isolate. Control seedlings were inoculated identically except sterile water was used. Inoculated plants were placed in a moisturizing light incubator at 25℃ and 80% humidity under a 12-h light/dark cycle for 7 days and examined daily to monitor disease symptom development. Small round brown spots were observed at the inoculation sites 3 days after the inoculation and eventually became large brown lesions. No symptoms wre observed in the water-inoculated plants. A Colletotrichum sp. strain based on morphology was reisolated from inoculated leaves, fulfilling Koch's postulates. For molecular identification, the direct colony PCR method (Lu et al. 2012) was used to amplify the internal transcribed spacer (ITS) region of ribosomal DNA, calmodulin (Cal), tubulin (Tub) and Apmat loci of three isolates using primer pairs of ITS4/ITS5, CL1C/CL2C, T1/T2 and AM-F/AM-R (Sharma et al. 2015). A phylogenetic tree derived from a maximum likelihood analysis of a concatenated alignment of ITS, Cal, Tub and ApMAT sequences was created. The accession numbers of the three isolates YamZJCS, YamSXCS and YamYLCS used in this study were OP128056-OP128058 for ITS, OP128059-OP128061 for ApMAT，OP128062-OP128064 for Cal and OP128065-OP128067 for Tub. The sequences of the 3 isolates were aligned with related species of Colletotrichum (Sharma et al. 2015). Analyses based on concatenated data sets of 4 genes showed that the sequences had high levels of identity to that of the C. siamense strains. According to both morphological and sequence analyses, the pathogen was identified as C. siamense. There were reports of anthracnose on yam caused by Colletotrichum sp. in Guangxi (Zhu et al. 2007), Hainan (Lin et al. 2018) and Jiangsu (Han et al. 2020) provinces in China. To our knowledge, this is the first report of anthracnose on D. opposita caused by C. siamense in Guangdong province in China.

European trends in ovarian cancer mortality, 1990–2020 and predictions to 2025

IntroductionOver the last decades, ovarian cancer mortality in Europe has been decreasing, but disparities in trends were observed. In this paper, we analysed ovarian cancer mortality trends in Europe over the period 1990–2020 and predicted the number of deaths and rates by 2025. MethodsWe extracted population and death certification data from ovarian cancer in women for 31 European countries, between 1990 and 2020 from the World Health Organization database. We computed age-standardised mortality rates (ASMR) per 100,000 women-years, based on the world standard population. We also obtained predictions for 2025 using a joinpoint regression model and calculated the number of avoided deaths over the period 1994–2025. ResultsOver the observed period, mortality from ovarian cancer showed a favourable pattern in most countries. In the EU-27, rates declined by 5.9% from 2010–2014 to 2015–2019, reaching an ASMR of 4.66/100,000. During the same period, the decline in ovarian cancer mortality was more pronounced in the EU-14 countries (−7.0%) compared to Transitional countries (−2.1%). Declines were also observed in the United Kingdom, to reach an ASMR of 5.29. Decreases in mortality from ovarian cancer are predicted until 2025, to 4.17/100,000 for the EU-27. ConclusionsFavourable trends in ovarian cancer mortality are expected to persist in Europe and can be mainly attributed to the increased use of oral contraceptives in subsequent generations of European women. Decreased use of menopausal Hormone Replacement Therapy and improved diagnosis and management may also have played a role.

Immediate Versus Delayed Mobilization After Cubital Tunnel Release Surgery: A Systematic Review and Meta-analysis

Purpose: It is unknown whether early mobilization after cubital tunnel decompression improves functional outcomes without increasing complication risks. This systematic review aims to evaluate the effectiveness of early mobilization compared to delayed mobilization of the elbow after ulnar nerve decompression. Methods: Randomized controlled trials (RCTs) and observational studies comparing adults who received early mobilization or late mobilization were included. Embase, MEDLINE, CENTRAL, PEDro, clinicaltrials.gov, and the World Health Organization database were systematically searched from inception to January 2023. Results: Of the 2183 studies identified and screened, five studies (two RCT and three observational) totaling 224 patients (232 elbows) were included in this review. Evidence from two RCTs (100 patients) suggests that early mobilization may result in a large reduction in the amount of time needed to return to work (mean difference 40.1 days, 95% confidence interval [CI] 16-64 days earlier, I2 = 85%, low-certainty evidence) and little to no difference in grip strength (0 kg, 95% CI = −0.17 to 0.17, I2 = 0%, low-certainty evidence). There was little to no difference in adverse events or range of motion (low to very-low certainty evidence). Pooled results from the three observational studies showed similar findings (very low-certainty evidence). There were no studies that evaluated upper extremity related quality of life. Conclusion: Immobilizing patients for periods longer than 3 days appears to delay patient's return to work with no appreciable clinical benefit.

Designing an Education Database in a Higher Education Institution for the Data-Driven Management of the Educational Process

During the past two decades, higher education institutions have been experiencing challenges in transforming the traditional way of in-class teaching into blended learning formats with the support of e-learning technologies that make possible the collection and storing of considerable amounts of data on students. These data have considerable potential to bring digital technologies in education to a new level of personalized learning and data-driven management of the educational process. However, the way data are collected and stored in a typical university makes it difficult to achieve the mentioned goals, with limited examples of data being used for the purposes of learning analytics. In this work, based on the analysis of existing information systems and databases at Siberian Federal University, we propose principles of design for a university database architecture that allow for the development and implementation of a data-driven management approach. We consider various levels of detail of education data, describe the database organization and structure, and provide examples of learning analytics tools that can benefit from the proposed approach. Furthermore, we discuss various aspects of its implementation and associated questions.

Infectious diseases prevention policies, strategies and measures: Literature review

&lt;b&gt;Introduction:&lt;/b&gt; Throughout the history, infectious diseases have been the most serious cause of morbidity and mortality of the population worldwide, as over the years there have been–and with the development of human activities–many significant outbreaks of infectious diseases. The threats they pose, including their resistance to antibiotics, make the review and development of public health policies a major issue.&lt;br /&gt; &lt;b&gt;Aim:&lt;/b&gt; The main purpose of this article is to present most recent policies and strategies on infectious diseases prevention via a literature review and highlight the necessity of developing a holistic approach to the formulation of infectious diseases prevention policies. Moreover, through the most recent literature on this topic it is observed that there is a need to draw up innovative policies, to defend public health and enforce the one health.&lt;br /&gt; &lt;b&gt;Methodology: &lt;/b&gt;For this literature review, a research in PubMed database and official organization was conducted and thus a total number (n=28) of articles and handbooks was collected. From PubMed database n&lt;sub&gt;1&lt;/sub&gt;=15 articles were extracted while from websites of official organizations n&lt;sub&gt;2&lt;/sub&gt;=13 was extracted. The final number of references that have been used for this paper was n=33 and were managed by using ZOTERO software.&lt;br /&gt; &lt;b&gt;Conclusion:&lt;/b&gt; It is clearly observed that collective work for prevent, and control infectious diseases is mandatory. Also, there is a need for strengthen the already existed public health systems, in order to be well-prepared. A major public health tool is communication, it is very important to communicate strategies and policies to individuals in a proper and comprehensive way.

Extracorporeal membrane oxygenation for the treatment of massive pulmonary embolism. An analysis of the ELSO database

AimExtracorporeal membrane oxygenation (ECMO) may be beneficial in treatment of massive pulmonary embolus (PE), however the current evidence to guide its use is limited. We aimed to compare the incidence, characteristics, treatments, and outcomes of patients with massive PE by mode of ECMO from a large international registry. MethodsRetrospective observational study of the Extracorporeal Life Support Organization (ELSO) database. ResultsA total of 821 patients underwent 833 ECMO episodes for PE. Mean age was 49 (±15) years, 408 (50.1%) were female, and 450 (54.7%) had a cardiac arrest prior to ECMO initiation. Venoarterial (VA) ECMO was the most common mode in 489 (58.7%), followed by extracorporeal cardiopulmonary resuscitation (ECPR) in 229 (27.4%) and venovenous (VV) ECMO in 85 (10.2%). The number of episodes per year increased over the study period, predominantly driven by an increase in ECPR. In-hospital mortality was the highest for ECPR 156/229 (68.1%), followed by VA ECMO 209/498 (42.7%) and VV ECMO 24/85 (28.2%) P < 0.001. After controlling for univariate and clinically significant variables at the time of ECMO initiation, increasing age (OR 1.02 (1.00–1.03), lower pH (OR 0.18 (0.03–0.44), lower diastolic blood pressure (OR 0.99 (0.97–1.00) and ECPR mode (OR 3.67 (1.46–9.230) were independently associated with in-hospital mortality. ConclusionECMO use for massive PE is increasing globally, and overall mortality rates compare favorably with other indications of ECMO. The use of ECPR and worsening metabolic status at initiation were associated with higher in-hospital mortality, suggesting delays in initiating ECMO should be avoided.

Lung Cancer Treatment Trends During the Coronavirus Disease 2019 (COVID-19) Pandemic: A Claims and Order Data Analysis (2019–2021)

IntroductionLung cancer is treated using systemic therapy, radiation therapy (RT), and surgery. This study evaluates how utilization of these modalities and cancer stage at initial treatment shifted from 2019 to 2021. MethodsClaims for lung cancer treatment were extracted from the database of a national health care organization offering Medicare Advantage health plans and paired with enrollment data to determine utilization rates. Seasonally adjusted rates were trended, with monotonicity evaluated using Mann-Kendall tests. Using contemporaneous prior authorization order data, the association between year and the patient’s cancer stage at the time of the initial RT or surgery order was evaluated through univariable and multivariable analyses. ResultsThe study considered 140.9 million beneficiary-months of data. There were negative and significantly monotonic trends in utilization of RT (p = 0.033) and systematic therapy (p = 0.003) for initial treatment between January 2020 and December 2021. Analysis of RT and surgery order data revealed that the patients were significantly (p < 0.001) more likely to have advanced (stage III or IV) cancer at the time of their surgery order in 2020 and 2021 than in 2019. After adjusting for urbanicity, age, and local income, a significant relationship between year of the initial order and presence of advanced cancer at the time of ordering was found for surgery orders placed in 2020 (p < 0.001) and 2021 (p < 0.01), but not for RT orders. ConclusionsThere was a per-capita reduction in lung cancer treatment in 2020 and 2021, and patients receiving initial orders for surgery after the onset of the pandemic had more advanced cancer.

Sublingual/Buccal buprenorphine and dental problems: a pharmacovigilance study

ABSTRACT Background The association between dental problems and sublingual/buccal buprenorphine is unclear. We conducted an analysis of dental adverse drug reactions reported with sublingual/buccal buprenorphine in VigiBase®, the pharmacovigilance database of the World Health Organization. Research design and methods We performed disproportionality analyses to compare the reporting rates of dental problems with sublingual/buccal buprenorphine, compared to other buprenorphine formulations and methadone. Significant signals were considered if the lower boundary of the 95% confidence interval of the Reporting Odds Ratio (ROR) was > 1; cases were ≥ 3 and p-value <0.05. We conducted sensitivity analyses by calculating the ROR according to the reporter’s qualification and the reporting continent (United States of America and Europe). Results We included 30,769 reports with all buprenorphine forms. We found 20 cases of dental problems with sublingual/buccal buprenorphine. Sublingual/buccal buprenorphine was associated with an overreporting of dental problems compared to other buprenorphine formulations (ROR = 15.10; 95% CI [7.50–30.39]; p < 0.005) and compared to methadone (ROR = 6.02; 95% CI [3.21–11.30]; p < 0.005). Overreporting of dental problems was consistent in sensitivity analyses, except in Europe compared with other buprenorphine formulations and with methadone. Conclusions Sublingual/buccal buprenorphine might increase the risk of reporting dental problems. However, these results do not modify the benefits of sublingual/buccal buprenorphine in the treatment of opioid use disorders.

Paratuberculosis Cases in the Livestock Industry in Nigeria: A Review

Paratuberculosis, also known as Johne’s (Yo’-ness) disease, is a significant bacterial disease of large and small ruminants, including other animals, caused by Mycobacterium avium subspecies paratuberculosis (MAP). Due to its impact on animal health and severe economic loss, the disease is recognized and reported in developed countries as a significant disease of livestock importance. The paper aims to review the current information about paratuberculosis in Nigeria. About 95 research articles were downloaded from various online journals databases such as Scopus, Google Scholar, Research Gate, PubMed, and CABI abstracts based on the following keywords: Johne’s disease, paratuberculosis, Africa, prevalence, Nigeria, report, occurrence, and Mycobacterium avium subspecies paratuberculosis. In addition to the perusal of organization databases, 60 research articles were used in writing this review article. Few cases and suspected cases of paraTB were reported in Nigeria by the World Organization for Animal Health (OIE). Despite growing global concerns, Johne's disease can be considered an unreported disease of livestock animals in Nigeria based on the knowledge gap and lack of reports about this significant disease of livestock animals. Studies need to be carried out to address the knowledge gaps before the disease becomes endemic and causes severe economic and public health menace in Nigeria and, by extension, Sub-Saharan Africa.

Chorea following SARS-CoV-2 infection and vaccination: a systematic review of reported cases

ObjectivesChorea following SARS-CoV-2 infection and vaccination, has been increasingly recognized. We aimed to synthesize clinical and paraclinical characteristics, treatment responses, and outcomes of this neurologic complication. MethodsWe systematically reviewed LitCOVID, the World Health Organization database on COVID-19, and MedRxiv up to March 2023, following a published protocol. ResultsWe included 14 chorea cases in patients with SARS-CoV-2 infection and eight following COVID-19 vaccination. Acute or subacute chorea preceded COVID-19 symptoms within 1-3 days or developed up to 3 months after infection. Frequently it was generalized (85.7%), with associated neurological manifestations (encephalopathy 35.7%; other movement disorders 7.1%). After vaccination, chorea had a sudden onset (87.5%) within 2 weeks (75%); 87.5% of cases presented hemichorea, with hemiballismus (37.5%) or other movement disorders; 12.5% presented additional neurological findings. Cerebrospinal fluid was normal in 50% of infected individuals but abnormal in all vaccinated cases. Brain magnetic resonance imaging detected normal basal ganglia in 51.7% of infection cases and 87.5% following vaccination. ConclusionIn SARS-CoV-2 infection, chorea may present several pathogenic mechanisms: autoimmune response to infection, direct infection-related injury, or an infection-related complication (i.e., acute disseminated encephalomyelitis, cerebral venous sinus thrombosis, hyperglycemia); also, previous Sydenham chorea may relapse. After COVID-19 vaccination, chorea could be due to an autoimmune reaction or other mechanisms (vaccine-induced hyperglycemia, stroke).

Adverse reactions following MPox (monkeypox) vaccination: An overview from the Dutch and global adverse event reporting systems.

The spreading of MPox (monkeypox) virus led to a vaccination campaign in the Netherlands for individuals at high risk of infection. This overview elucidates the characteristics of the reported adverse events following immunization (AEFI) following active immunization against monkeypox and thereby provides insight on the safety profile in daily practice. Data were collected from the spontaneous reporting system of the Netherlands Pharmacovigilance Centre Lareb. Furthermore, the global database of the World Health Organization was consulted on globally reported AEFI following smallpox or monkeypox immunization in 2022. Until 15 November 2022, 148 unique individual case safety reports (ICSRs) regarding monkeypox vaccination were received at Lareb. Two ICSRs reported a serious outcome (1.4%). A total of 2205 ICSRs were received in the global database in 2022, of which 131 reports (5.9%) concerned a serious reaction. Reported AEFI in both databases mainly included injection site reactions and general systemic reactions commonly observed after vaccination. The pattern of reported AEFI for monkeypox vaccines both in the Dutch and global ICSR database is generally in accordance with the manufacturer's product information and consists largely of injection site reactions and nonserious AEFI related to systemic reactogenicity.

INFORMACIONI SISTEM O ISTRAŽIVAČKOJ DJELATNOSTI U BOSNI I HERCEGOVINI: E-CRIS.BH I PERSONALNE BIBLIOGRAFIJE ISTRAŽIVAČA / CURRENT RESEARCH INFORMATION SYSTEM IN BOSNIA AND HERZEGOVINA: E-CRIS.BH AND PERSONAL BIBLIOGRAPHIES

The aim of this paper is to present the Information System on Research Activity in Bosnia and Herzegovina - E-CRIS.BH, and the total number of registered researchers, research organizations, departments and projects, but also the number of bibliographic records to which the typology of documents/works has been assigned within the mutual COBISS.BH database. E-CRIS.BH is an information system that represents an electronic database of researchers, research organizations, research departments and research projects. It is an information system on research activities in Bosnia and Herzegovina, which originated from the Register of Scientific Institutions, Scientific Staff, Scientific and Research Projects and Infrastructure Investments in the Federation of Bosnia and Herzegovina and the Register of Scientific Institutions, Scientific Staff, Scientific and Research Projects and Infrastructure Investments in Canton of Sarajevo. The Register of the Federation of Bosnia and Herzegovina is conceived as an umbrella system and the registers of the canton as its subsystems. The project was implemented by the Academy of Sciences and Arts of Bosnia and Herzegovina. The connection of E-CRIS.BH with the bibliographic database of COBISS.BH provides insight into the bibliographies of researchers, which are an integral part of every scientific work, a condition for synthesizing knowledge and data that lead to the required scientific results. The COBISS users have the opportunity to record researchers, research organizations, departments and projects necessary for the creation of a bibliography of researchers and organizations within their national library information systems in the COBISS.Net network (regional network). The results show that 2.230 researchers and 86 organizations have been registered so far in E-CRIS.BH. A total of 73.657 bibliographic records have been created so far within the COBISS.BH common database, which a typology of documents/works has been assigned to. In the first group – articles and other components – a typology was determined for 21.122 bibliographic records. In the second group – monographs and other completed works - a typology was determined for 52.372 bibliographic records. In the third group – performed works - (events) – a typology was determined for 163 bibliographic records.

Extracorporeal membrane oxygenation for cardiopulmonary failure in organ donation: Assessing liver transplant outcomes.

Liver transplantation continues to face significant organ shortages and efficient utilization of marginal donors is paramount. This study evaluates the practice patterns and outcomes in liver transplantation when utilizing allografts from marginal donors who required extracorporeal membrane oxygenation (ECMO) support. We performed a retrospective review of the Gift of Life (PA, NJ, DE) organ-procuring organization database for transplants performed using donors supported on ECMO for nondonation purposes. These were cross-referenced to the transplant recipients within the Organ Procurement and Transplantation Network database, and the outcomes of liver transplants using donors on ECMO support were compared with those not requiring ECMO. Organ use and nonuse patterns were then evaluated in ECMO-supported donors, identifying the factors associated with nonuse compared with the factors associated with graft failure. Thirty-nine of the 84 ECMO-supported donors contributing at least one intra-abdominal organ for transplant donated a liver. Graft survival and patient survival up to 5 years were comparable between transplants from ECMO and non-ECMO-supported donors, and no cases of primary nonfunction were seen in the ECMO group. ECMO support was not associated with 1-year graft failure on regression modeling. Additional regression analyses within the ECMO donor population identified bacteremia (HR: 19.81) and elevated total bilirubin at donation (HR: 2.44) as predictive of post-transplant graft failure. Livers from donors supported on ECMO before donation appear safe to use in select transplant settings. Better understanding of the impact of predonation ECMO on liver allograft function will help guide the optimal use of these scarcely used donors.

REMOTE MONITORING FOR 5P (PREDICTIVE, PREVENTIVE, PARTICIPATORY, PERSONALIZED, AND PRECISION) CARDIOVASCULAR MEDICINE: PROGRESS AMIDST COVID-19 PANDEMIC

The novel coronavirus disease 2019 (COVID-19) has emerged as a global pandemic that has affected the lives of billions of people. Clinical studies have reported an association between COVID-19 and cardiac diseases. Remote monitoring powered by wearable sensors impacts medical care by enabling health monitoring outside of the clinic. Wearable devices can provide a noninvasive and continuous multi-parameter assessment of ECG, Heart Rate Variability, arterial blood pressure, oxygen saturation and respiratory rate evaluation. Such monitoring may help predict and prevent cardiovascular events related to COVID-19 addresses the growing demand for a novel 5P (Predictive, Preventive, Participatory, Personalized, and Precision) medicine approach. This article aimed to review current and prospective advances in wearable devices for cardiac monitoring and their progress toward clinical application during the COVID-19 pandemic. We performed bibliometric analysis by Scopus, the largest and well organized bibliographic database and analyzed the top-cited articles in this field. Our analysis includes an overview of the most widespread practical implications of CVD-focused remote patient monitoring techniques based on wearable personalized devices. Assessment for both COVID-related conditions and general cases is included in the analysis. Recent studies have reported that cardiac abnormalities present in 19.7-27.8 % of hospitalized patients with COVID-19. COVID-19 associated myocarditis and heart rate abnormalities frequently occur. Additionally, patients with pre-existing CVD and hypertension are at high risk of worse outcomes. Data from several studies have identified atrial fibrillation as the most common form of arrhythmias in COVID-19 patients. Worsening of existing atrial fibrillation in COVID-19 patients is also a serious clinical concern. Implementation of wearable ECG devices for remote monitoring can improve the management of patients with atrial fibrillation and those at high risk for its development. Telecardiology based on wearable devices and remote monitoring allow out-of-hospital control of COVID-19 patients and patients suffering from chronic diseases at high risk of acute cardiovascular events, ensuring their early detection and tracking.

Perceived Future Outcomes of Unsuccessful Treatment and Their Association with Treatment Persistence Among Type-2 Diabetes Patients: A Cross-Sectional Content Analysis.

Despite the known strong association between patients' knowledge of outcomes of type 2 diabetes mellitus (T2DM) and treatment persistence, this knowledge in this patient population requires further clarification. The aim of our study was to reveal the perception of unsuccessful treatment outcomes among patients with T2DM and its association with treatment persistence by analysing answersto open-ended questions. In this cross-sectional study, 106 patients with T2DM who lived in Fukushima Prefecture, Japan, had a medical record in the Fukushima National Health Insurance Organisation database and had no cognitive problems were enrolled by purposive sampling. Treatment status was defined as "non-persistent" when a participant's treatment medical record was absent for a continuous period of ≥ 6months; otherwise, it was referred to as "persistent". We asked about the possible future problems of untreated T2DM, inductively classified the open answers into 15 codes and then statistically examined the association between these codes and treatment persistence using logistic regression analysis adjusted for age and sex. Persistent treatment was prevalent among participants who mentioned the code "treatment", which encompasses the terms that indicated invasiveness, such as dialysis, insulin injection, and shots (odds ratio 4.339; 95% confidence interval 1.104-17.055). Persistent treatment was prevalent among patients with T2DM who mentioned the code "treatment", suggesting that these patients may anticipate a threat due to the invasiveness of diabetes and thus participate in persistent treatment to avoid this threat. Healthcare professionals should provide appropriate information and supportive conditions to achieve both a reduced feeling of threat and persistent treatment engagement.

Global Pattern of Epizootic Ulcerative Syndrome Outbreaks in Freshwater Farmed and Wild Fish from 2005 to 2012

Epizootic ulcerative syndrome (EUS) is an infectious disease of freshwater farmed and wild fish caused by a fungus, Aphanomyces invadans. This disease is an important economic disease causing huge socio-economic losses to fish farmers across the world. While this is an important fish disease, its global epidemiology is poorly understood. The objective of this study is understand the global spatiotemporal epidemiology of EUS outbreaks from 2005 to 2022. The data were retrieved from open access database of the World Organization for Animal Health (WOAH). Results showed that there were a total of 277 outbreaks of EUS reported to WOAH from 2005 to 2022 from 15 countries and territories with 76% outbreaks reported from African countries. Democratic Republic of Congo reported the highest number of EUS outbreaks. Higher number of outbreaks were reported during 2014 to 2017. The observed epidemiological pattern might be biased due to the underreporting of the disease. Nevertheless, it offers important insights to understand the latest global pattern of EUS. We suggest to increase country level awareness on EUS so that outbreaks are reported in a timely manner.