Cooperation Organization Research Articles

Toxicological analysis and anti-inflammatory and antioxidant evaluations of extract, fractions and secoxyloganin obtained from Guettarda viburnoides Cham. & Schltdl. in mice

Ethnopharmacological relevanceGuettarda viburnoides, "veludinho do campo," is traditionally used for the treatment of pain and inflammatory conditions in humans; however, only one scientific study has reported this effect in an ear inflammatory model. Therefore, it is necessary to explore other in vivo models and the chemical composition of this medicinal plant. Aim of the studyA chemical investigation of methanolic extract of G. viburnoides (MEGV) (leaves) led to the isolation of secoxyloganin (GV-1). In addition, the preclinical safety of MEGV (in acute and subacute toxicological models, gavage = p.o.), antioxidants of MEGV, ethyl acetate (EAFGV) and hydromethanolic (HMFGV) fractions were tested using free radical scavenging and lipid peroxidation methodologies, and the anti-inflammatory effects of MEGV, HMFGV and GV-1 (p.o.) were evaluated on carrageenan and complete Freund's adjuvant (CFA) models of inflammation in mice. Materials and MethodsMEGV was obtained from air-dried leaves by maceration with methanol at room temperature. MEGV was then purified by liquid-liquid partitioning, to obtain the EAFGV and HMFGV fractions. Purification of HMFGV afforded GV-1. The quantification of total phenols, flavonoids, flavonols, and condensed tannins was subsequently performed for MEGV. The antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and oxidation of β-carotene were evaluated in MEGV and its fractions. The anti-inflammatory activity of MEGV (3, 30, and 100 mg/kg, p.o.) was assayed in carrageenan-induced models, followed by assessments of MEGV (100 mg/kg, p.o.), HMFGV (3 and 30 mg/kg, p.o.) and GV-1 (3 mg/kg, p.o.) in CFA- induced models in mice (including paw oedema, mechanical allodynia and cold sensitivity). Acute (14 days of MEGV, 2000 mg/kg, p.o.) and subacute (28 days, MEGV 30, 100, and 300 mg/kg, p.o.) toxicity was assessed in female Swiss mice. ResultsThe major compound was secoxyloganin (GV-1). The oral acute toxicity test of MEGV revealed no evidence of toxicity, indicating low toxicity according to the Organization for Economic Cooperation and Development (OECD) guidelines. In the subacute toxicity group, no clinical signs of toxicity or changes in body weight, water consumption, food consumption, or organ weight or morphology were observed after 28 days of gavage with MEGV (30, 100, and 300 mg/kg) compared with those in the control group. MEGV, EAFGV, and HMFGV showed significant free-radical scavenging and lipid peroxidation activities, with IC50 values ≤ 26.38 ± 4.56 μg/mL. In in vivo anti-inflammatory assays, MEGV (3, 30 and 100 mg/kg) reduced carrageenan-induced oedema (2 and 4 h) and hyperalgesia (3 and 4 h). In the CFA model, MEGV (100 mg/kg), HMFGV (30 mg/kg) and GV-1 (3 mg/kg) reduced inflammation (at 3, 4 and 24 h) in all parameters (oedema, mechanical allodynia and cold sensitivity). ConclusionThis study revealed that G. viburnoides has antioxidant and anti-inflammatory properties, and no toxicity was detected after acute or subacute gavage with MEGV, validating its traditional use in the treatment of inflammatory conditions.

Minilateralism and pathways to institutional progression: alliance formation or cooperative security governance?

ABSTRACT Even as essential definitional and conceptual issues related to ‘minilateralism’ remain unresolved, conjecture has arisen as to the future trajectories of established institutions, such as the Trilateral Strategic Dialogue (TSD), AUKUS, and the Quad. – Could they evolve into formal military alliances over time, or serve as the foundation of a new organisation aimed at providing regional security governance? To systematically evaluate such contingencies this article traverses a set of interrelated conceptual issues relating to minilateral institutionalisation. It seeks to differentiate minilaterals in terms of their ‘hybridity’ both in structural composition and functionality, and ascertain what this implies for their institutional progression. This process assists us in identifying on what grounds minilaterals might potentially evolve into a more formalised institutional paradigm – either (i) a military alliance or (ii) a cooperative security governance organisation. This foregoing conceptual apparatus is then brought to bear of on the case studies above to draw out clues as to their prospective institutional development pathways. The article concludes that, while such putative institutional transformations remain conceivable, in none of the cases is a particular pathway preordained. Instead, minilaterals may simply continue to adapt within the parameters of their present institutional boundaries.

Translation, a measure of force of attraction? States, international organizations and the consecrating power of translation

ABSTRACT Based on the premise that both translations and collective bodies have historically been used to build collective identities, shape their images, and defend their interests, this article examines several projects constituting the translation policy of the Intellectual Cooperation Organization (1925–1945) and the United Nations Educational, Scientific and Cultural Organization (1945–) from a soft-power perspective. In the first section, I identify several contemporary trends in translation studies that share an interest in the state, though I also delve into parallel critiques against methodological nationalism. The second section addresses states and international organizations as agents of translation that maximize the potential of translation as a soft-power resource. The third and the fourth section examine two specific translation projects as soft-power resources from the perspective of the producing end. The fifth section examines the way the press of the time covered said projects and discusses their reception in different social spaces. This case study is used as a heuristic tool to discuss states as relevant objects of study in translation studies, the multiple receptions of translations, and the consecrating power of translation.

China’s perception of minilateralism and Chinese-style multilateralism

ABSTRACT Chinese-style multilateralism, while exhibiting certain parallels with the emergent minilateral groupings in the Indo-Pacific—such as informality and issue-centricity—distinctly distances itself from these frameworks in official discourse. By examining the perspectives of Chinese scholars and official stances on minilateralism, and exploring China’s evolving conceptual preference for multilateralism, this study suggests that China’s circumspection is not solely attributed to the perceived antagonism and the confrontational undertones of minilateral frameworks in the region. It also stems from the intrinsic disparities between American minilateralism and China’s favoured multilateral approach, characterized by defensiveness, inclusivity, and a distinct preference for scale, with the latter further demonstrated by three case studies: the Shanghai Cooperation Organization (SCO), the Asian Infrastructure Investment Bank (AIIB), and the Lancang-Mekong Cooperation (LMC) mechanism. In this context, Chinese-style multilateralism emerges as a crucial strategy to enhance its resilience against possible scenarios of decoupling or ‘de-risking’ instigated by the U.S., aiming to achieve an equilibrium of institutional power and defend its role as a pivotal player in the Asia-Pacific region and beyond. This paper concludes by looking into the implications of Chinese-style multilateralism for the region as well as its prospect within China’s diplomatic endeavours.

Enhancing Malaysia’s Halal Brand Identity: Insights and Strategies for Sustainable Global Halal Hub

Halal branding has become an essential strategy for businesses to cater to the needs of Muslim consumers and tap into a rapidly growing market. Malaysia has positioned itself as a global halal hub, attracting Organisation of Islamic Cooperation (OIC) food manufacturers and becoming a trusted source of halal products and services. However, developing a distinct Malaysia’s halal brand identity remains a challenge. This article explores the importance of developing a strong halal brand identity for the sustainability of Malaysia as a global halal hub. The study conducted in-depth interviews with eight identified respondents who were either chief executive officers, presidents of participating companies, or partners and directors of various government agencies at local and international branches. The study discusses successful halal brand identity campaigns undertaken by major global and regional brands, focusing on promoting halal values, ethical practices, and the benefits of halal products. To develop a strong halal brand identity, comprehensive marketing and communication strategies are recommended, utilising the effects theory to craft effective digital marketing strategies that resonate with Muslim consumers and promote ethical consumption.

APPLICATION OF EUROPEAN CORPORATE GOVERNANCE PRINCIPLES IN THE PLANNING ACTIVITIES OF POST-WAR UKRAINE'S MULTI-LEVEL CONSUMER CO-OPERATION SYSTEM

The Association Agreement between Ukraine and the EU requires Ukraine to consider the adoption of a European model of corporate governance. The EU has a wealth of experience in the effective management of consumer co-operation, which can inform the development of best practices for Ukraine. The subject of the study is the adaptation and substantiation of the current specifics of the application of European principles of corporate governance in the process of planning the activities of a multi-level system of consumer co-operation in Ukraine. This study employs a range of general scientific methods, including modelling, economic analysis, forecasting, a system approach and synthesis. These methods have been used to develop generalisations and conclusions related to the object of research as a whole, namely the multi-level and multi-sectoral system of consumer co-operation in Ukraine. The objective of this study is to justify the implementation of European principles, mechanisms and tools of corporate governance, based on a comprehensive analysis, with the aim of optimising the planning processes and the development of a multi-level system of consumer co-operation in Ukraine. The fundamental characteristics of co-operative systems have been elucidated, and the principal distinctions between them and corporations have been identified. The functions of the corporate governance system are examined and a conclusion is reached regarding their alignment with the responsibilities and principles of consumer co-operation. The factors that contributed to the success of the development of the consumer co-operation trade sphere in the Soviet period are identified. This study considers the information base for planning the retail turnover of consumer co-operatives in the context of a planned economy. It identifies the main shortcomings and weaknesses of this approach. The principal indicators of activity for consumer co-operatives in Ukraine are examined in the context of their statutory mission. In light of the application of the substitution method, potential indicators of trade turnover for consumer co-operatives, contingent upon collaboration up to the level of 1990, are modelled. It can be concluded that the system of consumer co-operation has not yet fully adapted to the new economic conditions, new legislation and processes of increasing competition in the market, despite the transition to a market economy. In light of the aforementioned circumstances, it is imperative to implement European principles of corporate governance and contemporary international principles governing the advancement of the co-operative movement within the framework of consumer co-operation. The principles of corporate governance, developed by such international organisations as the Organisation for Economic Co-operation and Development, the European Confederation of Shareholder Associations, and the European Bank for Reconstruction and Development, have been subjected to detailed analysis. The evolution of the corporate governance system has been delineated with respect to the consumer co-operation. This trend coincides with the imperative necessity for the consumer co-operation of Ukraine to reform its planned system, which represents a key component of its commitment to more effective management. The necessity for additional harmonisation of Ukrainian co-operative legislation with European legislation has been established. The composition of the information base for the development of indicators of the plan of retail turnover of the consumer society in the modern context is justified. The article's primary conclusions are that the negative trends and the quantitative and qualitative indicators of consumer co-operatives in Ukraine can be halted and improved through the implementation and advancement of institutional co-operative advantages, which are codified by legislation and validated by both domestic and European experience. Consequently, members of consumer societies and potential shareholders must be regarded as a central object and subject of planning, regulation, operational activities and the development of consumer co-operatives. In the context of the implementation of the decentralisation policy in Ukraine, in order to optimise the relations between co-operative enterprises and organisations at the horizontal and vertical levels, it is necessary to plan the development of the co-operative system as a component of regional development. The use of IT technologies will allow automating all operational processes, using the full range of planning forms and methods, and at the same time preserving the scientifically sound principles of consumer co-operation development as a system with the possibility of medium- and long-term planning.

Evaluation of OECD Countries in Terms of Better Life Index According to Bulut Index

Background: The "Better Life Index", first developed by the Organization for Economic Co-operation and Development (OECD) in 2011, includes many criteria from the functioning of public services to environmental wealth, from security services to individual and social well-being. Method: The performances of OECD countries according to the decision criteria that constitute the Better Life Index has been evaluated with Bulut Index (BI) method, which is a multi-criteria decision-making method. Normalized Maximum Values (NMV) method, one of the objective weighting methods, was used to determine weights of decision criteria. Findings: Among the indicators of the Better Life Index, the murder rate per 100 thousand population ranks first in terms of criterion weight. In the study, due to the analysis and evaluation made with Bulut Index, Switzerland ranked first among OECD countries with 82.28 points in the welfare and well-being index ranking. On the other hand, Türkiye ranked fourth from the bottom among OECD countries. Conclusion: Based on the findings of the study, it is recommended that urgent and necessary measures be taken on homicide rates, long-term unemployment rates and air pollution criteria. The lack of criteria regarding civic participation, work-life balance and income status constitute limitations of the study. In future studies, it is especially recommended that other researchers include these variables.

The effect of global collaboration on climate mitigation technologies in reducing CO2

The fundamental approaches to industrial growth, government interventions, and market structure have ignored the main consequences of the common idea of “growth first, clean later”. This study investigates the relationship between carbon emissions (CO2) and international collaboration in climate change mitigation technologies (ICCCMT), renewable energy consumption (REC), exports (EXP), imports (IMP), gross domestic product (GDP), foreign direct investment (FDI), natural resources rents (NRR), and domestic innovation in climate change mitigation technologies (DICCMT) for a panel of the Organization for Economic Cooperation and Development (OECD) countries over the period of 1990-2020. We adopted a series of econometric techniques for the visualization of the available data. We used second-generation econometrics estimations to verify cross-sectional dependence, co-integration, and stationary between the variables.Based on our findings, the study reveals that ICCCMT, REC, and DICCMT have a positive effect and contribute to CO2 mitigation of the 30 OECD economies. Furthermore, the findings reveal that ICCCMT can promote renewable energy consumption, thus the increase of REC will significantly mitigate CO2 emissions. The outcomes from the panel dynamic GMM model confirmed a positive relationship between CO2 emissions, FDI, exports, imports, and GDP. The study indicates that these variables can adversely affect climate change mitigation.

Asymmetric distance and business cycles (ΑDBC): A new understanding of distance in international trade models through the example of Iran's trade corridors

We introduce a new concept of distance, and the way this could affect gravity-based trade modeling. Our motivation is twofold: a) global uncertainty in trade relations allows us to treat distance as an asymmetric shock in economic modeling; b) economies of scale in seaborne trade make geographical distance less relevant in trade models, substituted by economic distance, as this can be proxied by ocean freight rates. This, for instance, allows China to import iron ore from Brazil, at three times the distance compared to Australia. We enhance the New Keynesian Dynamic Stochastic General Equilibrium Model (DSGE) by incorporating a distance shock parameter into the transaction costs function. We test this on Iran's participation in the Shanghai Cooperation Organization as well as in the International North-South Transport Corridor. We conclude that longer physical distances do not necessarily have a negative impact on trade.

Collection and use of patient-reported experience measures: approach to improve health care

Abstract Background Patient experience is one of the fundamental determinants of healthcare quality. There is progress in the collection of PREM in national level for hospitalized patients since 2020 in Latvia. Aim Analyze (2020.-2022.) in-patients Top-box rates about communication, share-decision making, patient safety and Net Promoter Score (NPS). Methods Project starting point was 2019. Agreement with EC, Sant’Anna School, Ministry of Health and Centre for Disease Prevention and Control of Latvia. Since 2020, the collection of PREM has been taking place regularly in hospitals (around 40% from all hospitals) and on average 20% response rate of those who agreed to participate in the survey. PREM questionnaire according to HCAHPS (Consumer Assessment of Healthcare Providers and Systems) standards, including Picker Institute patient experience questions. In line with OECD (Organization for Economic Co-operation and Development) recommendations, patient safety issues are also included. Top-box rates (most positive response) and percentiles (25th - 75th) were calculated. Results Totally 17019 adult (18 years and more) patient responses were analyzed with response rate 20.3% (n = 83983). 74.6% (67.5-78.2) during hospital stay doctors always explain things in a way you could understand and sufficiently involved in the decision-making process of treatment - 75.0% (70.1-81.4). During hospital stay 4.1% (n = 601) experienced patient safety incidents which were patient-reported. The most common groups were wrong patients, medication errors, incl. adverse drug reactions and falls. Hospitals achieved a NPS of 61 for 3 year period (2020.-2022.). Conclusions Collecting information about the patient experience may be the starting point for engaging patients and moving to more patient-centered health care. The results of these in-patient PREM data can be used to identify areas of improvement and make changes to better meet the needs and expectations of their patients. Key messages • It is a good practice for the implementation of new health care quality data - patient experience reported measures at the national level. • Feedback about the patient experience on regular basis provides insight into patient needs, preferences and values, which can help to improve the quality and safety of care.

Toxicological evaluation of LivLonga®, a polyherbal combination, in rodents

There has been keen interest on herbs and phytoconstituents with hepatoprotective property to help restore healthy liver function. Ayurveda, the ancient Indian traditional system of medicine mentions about Curcuma longa, Garcinia indica and Piper nigrum which are reported to have hepatoprotective activity. Apart from supporting metabolism, liver plays pivotal role in numerous bodily processes, immune functions to digestion, detoxification, and storage of nutrients. Factors such as sedentary lifestyle, viral infections, drugs/chemicals, high calorie diet, excess intake of alcohol etc have adverse impact on normal functioning of liver. Development of novel herbal combination with standards of safety and efficacy can help manage liver ailments and protect liver health. LivLonga® is a polyherbal combination of scientifically validated ingredients- curcuminoids, garcinol and piperine to support healthy liver function. The present work was conducted to evaluate toxicity of LivLonga® using in vivo models when administered orally. The acute, subacute, and subchronic toxicity studies were carried out in accordance with the test guidelines established by the Organization for Economic Cooperation and Development. A single-dose acute oral toxicity produced no toxic effects after 14 days of treatment. Four-week (subacute) and 3-months (subchronic) oral toxicity studies were conducted and observed no abnormal clinical signs, no alterations in the body weight, hematology and biochemical parameters or gross and histopathological changes. Thus, oral administration of LivLonga® showed no signs of toxicity when dosed orally to rats, with a no observed adverse effect level (NOAEL) of 600 mg/kg/day.

Impact of the Implementation of Multilateral Convention on Tax Treaty by the Adoption of Organization for Economic Co-operation and Development (OECD) in collaboration with the G02 countries on Base Erosion and Profit Shifting (BEPS)

Impact of the Implementation of Multilateral Convention on Tax Treaty by the Adoption of Organization for Economic Co-operation and Development (OECD) in collaboration with the G02 countries on Base Erosion and Profit Shifting (BEPS)

Global variations in coronary revascularisation and acute myocardial infarction mortality between 2006-2020: a longitudinal, population-level analysis of 16 high-income nations from the OECD database

Abstract Background Revascularisation options for ischaemic heart disease (IHD) includes either, percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). Whilst PCI remains the preferred choice in ST-elevation myocardial infarction (STEMI)(1), several landmark trials have questioned its universal superiority (2,3), thus prompting re-evaluation of guidelines. A wide-scale contemporary overview of revascularisation trends is lacking. Purpose To examine the evolving pattern in PCI and CABG rates, alongside mortality from acute myocardial infarction (AMI) across a group of 16 high-income countries between 2006 and 2020. Methods Standardized PCI and CABG procedure rates alongside AMI age-standardised mortality rate (ASMR) were obtained from the Organisation for Economic Co-operation and Development (OECD) database. Data from 2006-2020 was extracted for; Australia, Austria, Belgium, Canada, Denmark, Finland, France, Germany, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, United Kingdom (UK). Together, these countries are commonly known as the European Union (EU) 15+ and represent a cluster of high-income nations with comparable levels of health expenditure. Procedural trends including the estimated annual percentage change (EAPC) were evaluated using Joinpoint analysis whilst Locally Weighted Scatterplot Smoothing (LOESS) models was used to analysis trends in AMI mortality. Results Over 15 years, 14.0 million PCI and 2.8 million CABG procedures were recorded in total. PCI rates varied amongst nations (Figure 1), however showed an overall increase in 11 countries, led by Finland (+36.0%). The steepest increase was observed in France between 2012-2018 (EAPC 5.4, 95% CI: 4.8 – 6.1). The greatest overall decrease in PCI was observed in Luxemburg (-33.5%). The fastest decrease was seen during 2018-2020 in the UK (EAPC -7.2, 95% CI: -9.7 – -4.6). CABG rates declined overall in 15 countries (Figure 1), with Luxembourg (-71.3%), experiencing the largest fall and showing the steepest decline between 2014-2018 (EAPC -20.7, 95% CI: -28.3 – -12.3). Ireland was the only country to show an increase in CABG rate (+16.3%). Throughout the study period, the PCI-to-CABG ratio increased (Figure 2A), whilst AMI mortality decreased consistently across all countries (Figure 2B). Conclusion Despite evidence supporting CABG over PCI in specific scenarios, CABG rates have declined, and PCI rates have increased. This trend may be influenced by several factors including patient preference for less invasive procedures and advancements in interventional techniques. The varied use of PCI among these nations, alongside a sustained decline in AMI mortality rates, may be expected given the importance of optimal medical therapy in the management of IHD. The results further highlight the significance of factors beyond revascularisation in driving improved outcomes.PCI and CABG rates between 2006 and 2020PCI to CABG ratio and AMI mortality rate

Association between all-cause mortality and diabetic avoidable hospitalization among older patients

Abstract Background In South Korea, the prognosis of avoidable hospitalization in diabetes has not been evaluated, even though the incidence rate is considerably high compared to the Organization for Economic Co-operation and Development average. This study investigated the association between diabetic avoidable hospitalization after the diagnosis of type 2 diabetes mellitus and short- and long-term all-cause mortality. Methods Participants were type 2 diabetes mellitus patients aged 60 years and older and gathered through the National Health Insurance Services Senior cohort data from 2008 to 2019. The outcome measures included five-year and overall period all-cause mortality. The main independent variable was the first-year experience of diabetic avoidable hospitalization after type 2 diabetes mellitus diagnosis. Regression analysis was performed using the Cox proportional hazard model. To enhance the robustness of the study results, a sensitivity analysis and inverse probability of treatment weighting method were conducted. Results Among 31 222 participants, 2343 (7.5%) died within 5 years of type 2 diabetes mellitus diagnosis and 5314 (17.0%) died in the overall study period after type 2 diabetes mellitus diagnosis. Participants who experienced diabetic avoidable hospitalization one year after being diagnosed with type 2 diabetes mellitus had a higher risk of all-cause mortality compared to those who did not (Five-year: hazard ratio 1.84, 95% confidence interval 1.54-2.21; Overall period: hazard ratio 1.81, 95% confidence interval 1.60-2.06). Conclusions Enhancing accessibility and quality of primary care to prevent avoidable hospitalization in older patients with type 2 diabetes mellitus is necessary. Key messages • Older patients with T2DM who experienced avoidable hospitalization exhibited higher all-cause mortality rates in both the short and long terms. • Enhancing the accessibility and quality of primary care to prevent avoidable hospitalization in older patients with type 2 diabetes mellitus is necessary.

10.E. Scientific session: Confronting the hidden risks: unveiling the disease burden of chemicals in Europe

Abstract With increasing industrialization and globalization, Europe faces a complex landscape of chemical hazards, ranging from persistent organic pollutants like PFAS to foodborne chemicals and beyond. Understanding the extent of these exposures and their associated population health risks is crucial for environmental and health policy making across Europe. The burden of disease methodology, particularly through metrics such as Disability-Adjusted Life Years (DALYs), combined with economic costs, plays a crucial role in assessing and addressing the impacts of chemicals on population health. DALYs provide a comprehensive measure that quantifies both the years of life lost due to premature death and the years lived with disability, offering a holistic understanding of the disease burden caused by chemical exposures. Additionally, incorporating economic costs into the analysis enables the evaluation of the financial burden imposed by chemical-related illnesses on healthcare systems, productivity, and societal well-being. By leveraging the burden of disease methodology, stakeholders can make evidence-based decisions to protect health of populations and allocate resources effectively, ultimately promoting healthier environments and communities. Several global and European initiatives provide platforms for evidence generation, knowledge-sharing, and action to address the disease burden of chemicals. At the global level, the Foodborne Disease Burden Epidemiology Reference Group of the World Health Organization (WHO/FERG) has estimated the global burden of foodborne diseases, including those caused by chemical contaminants in foods. At European level, the health impact of PFAS and other chemicals of high concern is being spearheaded by the European Environment Agency’s European Topic Centre on Human Health and the Environment, and the European Partnership on the Assessment of Risks from Chemicals (PARC). Furthermore, the Organisation for Economic Cooperation and Development has established a project of an unprecedented scale to measure the economic value of the effects of chemicals on human health. Complementary to these international initiatives, various countries have started to unravel the burden of chemicals based on local data and contextual insights. In this workshop, we will present the state-of-the-art of the disease burden of chemicals, by bringing together insights from key international and national burden of disease initiatives, emphasizing the imperative of addressing the cost of policy inaction in safeguarding public health. We will also show how burden of disease estimates for chemicals can help to monitor the trends towards relevant environment and health goals such as those described in the EU’s zero pollution ambition. Through collaborative discussions and knowledge-sharing, we aspire to identify actionable strategies for policymakers, researchers, and stakeholders to effectively address these challenges and promote a healthier future for all. Key messages • Understanding the vital importance of chemical risks for European health, the utilization of DALY and economic costs reveals their true burden, guiding evidence-based policies. • Global, regional and national initiatives are examining the impacts of chemicals worldwide, contributing to evidence gathering and policy shaping.

Observed carbon decoupling of subnational production insufficient for net-zero goal by 2050

Historically, economic growth has been closely coupled to carbon emissions responsible for climate change, but to stabilize global mean temperature, net-zero carbon emissions are necessary. Some economies have begun to reduce emissions while continuing to grow, but this decoupling is not fast enough to achieve global climate targets. Subnational climate actions seem to be crucial for the achievement of these targets. Here, we uncover the effectiveness of subnational efforts by estimating decoupling rates and CO2 emission intensities over the last three decades for over 1,500 subnational regions, encompassing 85% of global emissions, using global data on reported economic output and gridded production-based emissions. Thirty percent of regions with available data have fully decoupled, with higher-income and historically carbon-intensive regions exhibiting higher rates of decoupling and declining emission intensity. Countries of the Organization for Economic Co-operation and Development with greater spending on subnational climate actions show higher decoupling rates, as do subnational regions in EU countries where climate policies have been implemented, highlighting the effectiveness of subnational policies. Moreover, subnational analysis reveals greater variance of decoupling rates within national boundaries than between them and that countries with weaker governance typically show higher variance of decoupling within their borders. If recent rates of production-based carbon decoupling continue, less than half of subnational regions would reach net-zero before 2050, even when accounting for observed acceleration via socioeconomic development and assuming no interregional carbon leakage.

Ideology, financial circumstances, and attitudes toward public and private foreign aid

Does ideology influence voter preferences for foreign aid in the same way it does for domestic redistribution? Economically vulnerable left-leaning citizens, who are normatively strong proponents of government aid, may not be as committed to increasing actual spending. Such citizens may see themselves as competing with the foreign poor for domestic resources. Similarly, while affluent right-leaning citizens may oppose increasing foreign aid due to skepticism about government spending, this might not extend to private donations. Instead, they may view non-governmental organizations and charities as alternatives that leverage private expertise to assist poor countries. Using four years of public opinion data from 15 Organisation for Economic Co-operation and Development donor countries, I find support for the conditional effect of ideology and economic self-interest on both public and private aid attitudes. By focusing on three different measures—the morality of aid, public aid spending, and private donations—I further explore variations in aid attitudes.

COOPERATION OF EU AND UKRAINIAN YOUTH ORGANIZATIONS DURING THE 1990s (Based on the Documents of the EU Historical Archive)

The article highlights the development of relations between European and Ukrainian youth organisations after 1991, as well as the challenges that Ukraine has faced in establishing these relations. The author notes that there is currently no research on the cooperation of European youth organisations with Ukrainian youth organisations after 1991. This study was developed thanks to a grant from the Visegrad Fund for Research of the Historical Archive of the European Union. Access to original materials stored in the Historical Archive of the European Union allowed to analyse the main milestones in the development of cooperation between Ukrainian and European youth organizations after restoring Ukraine's independence. The article analyses the change in attitude towards the countries of Eastern Europe as potential partners in the last decade of the existence of the Soviet Union, as well as after its collapse. It was concluded that the opposition between the Soviet Union and Western Europe negatively influenced the development of relations between youth organizations in the transition period. The author concludes that after restoring Ukraine's independence, Ukrainian youth organizations made significant efforts to establish cooperation with European organizations. However, the state did not have enough funds for the development of foreign youth policy and the necessary knowledge due to the lack of experience in cooperation with Western European partners.

Addressing contemporary challenges of Human Resource Development in Private and Cooperative sector milk processing organizations in Pune region

HRD practices in private and cooperative sector milk processing organizations in Pune region were investigated through 175 management and 1195 employee respondents of selected milk processing organizations from both the sector by adopting proportionate convenience sampling technique; which indicates that overall, fair & poor level of HRD practices found in private and cooperative milk processing organizations in Pune region; an enlightened organization would initiate immediate drastic HRD interventions to prevent the situation from deteriorating further by designing/re-designing effective HRD policy and developing good HRD practices. Management of both the sector milk processing organizations needs to design the existing HRD policy in line with standard practices so as to develop good HRD culture. Again, in between the two sectors, private and cooperative sector milk processing organizations in Pune region, cooperative sector was noticed to be drag behind by most of the poor HRD practices and indicating the acute need for addressing the issues. It strongly indicates the need for addressing the challenges of HRD practices being followed by implementing all HRD practices as per standard way to get the best HRD practices result in both the sectors milk processing organizations so as to sustain in global competition.

Assessing the Damage to Environmental Pollution: Discerning the Impact of Environmental Technology, Energy Efficiency, Green Energy and Natural Resources

The existing literature covers the topic of environmental pollution, but there is a scarcity of research that specifically examines the factors contributing to financial losses caused by carbon emissions. In this perspective, this ongoing analysis provides an understanding of the impact of environmental technology, energy efficiency, renewable energy consumption, natural resources, and economic growth on carbon dioxide damage in Organization for Economic Cooperation and Development (OECD) countries from 2000 to 2021 using the “Method of Moments Quantile Regression (MMQR)”, and “Dumitrescu–Hurlin (D-H)” causality test. The findings from the MMQR revealed that environmental control technology, renewable energy consumption, and energy efficiency contribute to reducing carbon dioxide damage at different quantiles. It was also found that economic growth and natural resources contribute to the increase in carbon dioxide damage in various quantities. Additionally, a one-way causality result was obtained from environmental technology, energy efficiency, renewable energy consumption, natural resources, and economic growth towards carbon dioxide damage. These results indicate that policymakers in OECD nations should provide suggestions on the efficient utilization of renewable energy sources and environmentally friendly technologies to minimize carbon dioxide damage.