AbstractNutrient‐rich organic waste derived from sewage treatment facilities or livestock manure is often applied to rangelands of western North America to increase soil fertility, forage production, forage quality, and soil carbon storage. This practice can have a number of undesirable side effects, however, including plant invasion. While characteristics of both rangeland ecosystems and invasive plants suggest that organic waste application might often promote invasion, results to date are mixed, perhaps due in part to the paucity of long‐term studies. Here, we describe the long‐term (22 yr) effects of three types of organic waste—composted biosolids, composted cattle manure, and fresh cattle manure—on plant productivity and invasion in native mixed‐grass prairie. Although composted manure and biosolids increased plant productivity and forage quality in the second year of the study, these effects did not persist. In contrast, Bromus tectorum (cheatgrass), which invaded the study site over the course of the experiment, was strongly facilitated by composted manure addition, with particularly large effects observed in years 17 and 22. These results show that nutrient‐rich organic waste can favor invasive species even in the relatively invasion‐resistant grasslands of the western Great Plains. They also demonstrate that effects of organic waste on invasion can become apparent quite gradually and persist for decades following the initial organic waste application. Together, results from experimental additions of organic and inorganic nutrients to native rangelands suggest that the risk of promoting invasive species is significant, and should be considered in programs that apply organic waste to rangelands of western North America.