A study was conducted to assess the impact of Nano-Zn, inorganic, and organic nutrient management practices on the physico-chemical properties and nutrient availability in Kharif maize (Zea mays L.) grown during 2022 and 2023 at Chandra Shekhar Azad University of Agriculture & Technology, Kanpur. The experiment followed a split-plot design, with organic manures (Control, FYM at 10 t/ha, and Vermicompost at 5 t/ha) as the main plot treatments and various nutrient management strategies (Control, 75% RDF, 75% RDF + ZnSO4 at 25 kg/ha, 75% RDF + Nano-Zn at 10 ml/litre, 100% RDF, 100% RDF + ZnSO4, and 100% RDF + Nano-Zn) as the subplot treatments. Results showed that combining 100% RDF with Nano-Zn and ZnSO4 significantly enhanced soil nutrient availability and improved physico-chemical properties compared to control treatments. The organic carbon content was highest in the 100% RDF + Nano-Zn treatment (0.492%), suggesting an increase in soil organic matter. Nitrogen availability was significantly higher in this treatment, with a pooled value of 151.167 kg/ha, compared to 143.443 kg/ha in the control. Phosphorus availability also increased in the 100% RDF + Nano-Zn treatment (16.337 kg/ha), indicating better phosphorus mobilization. Potassium availability was enhanced, with the highest recorded value (216.39 kg/ha) in the 100% RDF + Nano-Zn treatment, while the control treatment had 213.597 kg/ha. Zinc availability was markedly improved, with the 100% RDF + Nano-Zn treatment reaching 0.853 mg/kg, compared to 0.79 mg/kg in the control. This study demonstrated that integrating Nano-Zn and ZnSO4 with inorganic fertilizers significantly improved soil fertility, nutrient availability, and potentially enhanced crop performance in Kharif maize. These findings indicate that combining inorganic and nano-fertilizers could be an effective nutrient management strategy, contributing to sustainable agricultural practices and improved productivity in maize cultivation, alongside better soil health.