The performance of a desiccant-filled polyisobutylene edge sealant for organic electronics is reported. The sealant was applied through a low temperature lamination process using glass substrates and various seal widths. The performance was tested using the Ca corrosion method at 50°C and 80% relative humidity (RH). Data show an effective water vapor transmission rate (WVTR), on the order of 10−3g/m2/day in the transient regime with a breakthrough time greater than 1400h for seals 1.5mm wide and 0.3mm thick. By changing the sealant architecture, the breakthrough time was increased with similar effective WVTRs. Finally, the sealant was applied to organic electrochromic devices, which displayed a retention of performance after 1000h of storage at 50°C and 80% RH.