Since 1960, cotton cultivation has experienced considerable expansion in the Koutiala district of Mali. This expansion has not been without consequences on people’s health and natural resources in terms of soil, water and natural vegetation. Based on the analysis of satellite images and a socio-economic survey of production unit chiefs, this study highlights the degradation of soils, biological diversity, population health, and pollution of groundwater and surface water. To reduce these effects, the adoption of good agroecological practices, the organic cotton farming, the reduction of the use of chemicals, and the sustainable management of water and soil are becoming a necessity to ensure sustainable management of environmental resources and the preservation of the livelihoods of local producers.
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