Oregon Adolescent Depression Project Research Articles

Examining the influence of episode number and age of onset on individual depressive symptoms across episodes of major depression

Major depression is characterized by an episodic course with symptom manifestations differing across episodes. Previous work has found that symptom presentation differs across age. However, studies of symptom presentation have largely focused on symptoms in individual episodes, requiring further investigation of longitudinal symptom change. This study explored the impact of the initial age of onset, the number of episodes, and age of onset of each episode on individual depressive symptoms, while accounting for episode severity. We used data from the Oregon Adolescent Depression Project (N = 629) examining participants with at least one major depressive episode, assessed by diagnostic interview, across a 15-year follow-up. Multilevel logistic regression models revealed that approximately 20–25% of the main effects were significant and some were qualified by cross-level interactions. However, only a few associations remained robust after correcting for multiple comparisons. Specifically, older initial age of onset was associated with fatigue, younger initial age of onset for the first episode was associated with suicidal ideation, and a lower episode number was associated with weight loss. These findings highlight potential initial age of onset and scar effects influencing symptom manifestation, but require replication.

Family-Based Predictors of Alcohol Use Disorder (AUD) Recurrence and New Non-Alcohol Substance Use Disorder Onset Following Initial AUD Recovery

Knowledge of factors that predict alcohol use disorder (AUD) recurrence or the subsequent switching to a different substance use disorder (SUD) after initial AUD recovery is especially crucial for preventive efforts that seek to alter life courses dominated by problematic substance use. This study evaluated whether the proportions (or densities) of first-degree relatives with AUD and non-alcohol substance use disorder (NASUD) histories predicted AUD recurrence or a new NASUD onset in a family member (i.e., proband) following initial AUD episode recovery. This research is based on a prospective and multigenerational data set collected as part of the Oregon Adolescent Depression Project (OADP). The initial proband cohort was selected randomly from nine high schools in western Oregon. The sample for this research consisted of OADP probands with histories of AUD who recovered from their first AUD episode by age 30 (n = 244). Lifetime SUD histories were also assessed for first-degree adult relatives of probands (n = 790). In unadjusted and partially adjusted analyses, family densities of AUD predicted AUD recurrence among probands, and family densities of NASUDs predicted the onset of a new NASUD following first-episode AUD recovery. In fully adjusted analyses, the effect for AUD family histories on proband AUD recurrence remained, whereas the effect for family NASUD histories on new NASUD emergence was not maintained. Family SUD histories have predictive relevance for the course of AUD following initial recovery as well as some specificity for the type of SUD recurrence subsequently experienced.

Longitudinal predictors of suicidal ideation: Emerging to early adulthood

Few studies have examined the longitudinal trajectory of suicidal ideation (SI) in community samples, particularly during emerging adulthood. Additionally, there is scant data on predictors of longer-term course of SI across this period. We examined multiple domains of adolescent psychosocial and clinical functioning as predictors of SI trajectory and explored whether biological sex moderates those associations. The data came from the Oregon Adolescent Depression Project. Participants completed self-reports of psychosocial and clinical functioning and interviews assessing psychopathology in mid-late adolescence. SI was assessed using up to seven annual mailer assessments spanning ages 19–31. Multilevel growth models found that SI declined across emerging adulthood. Multiple indices of adolescent functioning were associated with higher levels of SI three years later. Few adolescent functioning constructs predicted faster reductions in SI, and no constructs predicted slower longitudinal reductions (or increases) in SI. Similar associations were found when controlling for adolescent SI. Lastly, we found little evidence for sex differences in these associations. This work shows that adolescent functioning is largely associated with initial and enduring levels of SI. Moreover, associations were similar between sexes. Given the modest associations found across long periods of time, future research should focus on proximal risk factors for SI.

Latent Class Analysis of Adolescent Psychosocial Functioning and Course of Major Depression.

There are few studies on the predictors of long-term course of major depressive disorder (MDD) with an onset in childhood and adolescence. Studies have relied on variable-centered methods, utilizing psychosocial and clinical characteristics to predict depression outcomes. However, fewer studies have used person-centered approaches that rely on profiles of functioning to predict course and outcomes of depression. This study examined the long-term course and outcome of early onset depression as a function of profiles of psychosocial and clinical characteristics in adolescence. Participants from the Oregon Adolescent Depression Project with a history of MDD by study entry (Mage = 16.29years) and who had follow-up assessments at age 30 were included (n = 215). Psychosocial and clinical constructs, including domains of internalizing problems, externalizing problems, correlates of internalizing problems, adolescent stress, and social support, were assessed in adolescence. Latent profile analyses found a 3-class solution with Low Negative Cognitive Style (LNCS; 27.9%); Internalizing and High Negative Cognitive Style (INT/HNCS; 53.9%); and Internalizing and High Negative Cognitive Style plus Poor Interpersonal Functioning and High Stress (INT/HNCS+ ; 18.1%). Overall, classes differed in depression morbidity, such that the INT/HNCS+ class had the greatest depression morbidity across follow-up assessments. Social adjustment differed between all classes, with the INT/HNCS+ class showing the worst functioning, the LNCS class showing the best functioning, and the INT/HNCS class falling in the middle. Patterns of clinical and psychosocial functioning were differentially associated with long-term depression and social adjustment among youth with depression.

Validity of retrospectively-reported depressive episodes

BackgroundDepression and other psychopathology are often assessed retrospectively. Few studies have evaluated the validity of these reports by comparing prospectively-assessed symptoms to retrospective reports during the same time period. MethodsThis study utilized a subset of participants (n = 68) from the Oregon Adolescent Depression Project who completed at least one mailer assessment of depressive symptoms during a retrospectively-reported depressive episode. Participants completed up to seven mailer assessments of depression and suicidal ideation and diagnostic assessments that included retrospectively-reported depressive episodes that coincided with the mailer assessments. ResultsMultilevel linear models examined differences in depressive symptoms and suicidal ideation during and between retrospectively-reported depressive episodes. Results showed that individuals reported significantly higher levels of depression and suicidal ideation for retrospectively-reported depressive episodes compared to when they were not in depressive episodes. In addition, the average level of depressive symptoms endorsed during retrospectively-reported depressive episodes reached established clinical cut-offs. LimitationsAlthough we were able to determine whether symptoms during retrospectively-reported depressive episodes approached clinical cut-offs, we were unable to examine whether symptoms met criteria for depressive episodes. Additionally, we could not examine whether episode severity related to recall ability, and other forms of psychopathology were not assessed. ConclusionThese findings provide critical evidence for the validity of retrospectively-reported depressive episodes. Future research should examine whether these findings generalize across varying recall periods and retrospective assessments for other psychopathology.

Profiles of psychosocial and clinical functioning in adolescence and risk for later depression and other outcomes

Most studies examining predictors of the onset of depression focus on variable centered regression methods that focus on the effects of multiple predictors. In contrast, person-centered approaches develop profiles of factors and these profiles can be examined as predictors of onset. Here, we developed profiles of adolescent psychosocial and clinical functioning among adolescents without a history of major depression. Data come from a subsample of participants from the Oregon Adolescent Depression Project who completed self-report measures of functioning in adolescence and completed diagnostic and self-report measures at follow-up assessments up to approximately 15 years after baseline. We identified four profiles of psychosocial and clinical functioning: Thriving; Average Functioning; Externalizing Vulnerability and Family Stress and Internalizing Vulnerability at the baseline assessment of participants without a history of depression at the initial assessment in mid-adolescence. Classes differed in the likelihood of onset and course of depressive disorders, experience of later anxiety and substance use disorders, and psychosocial functioning in adulthood. Moreover, the predictive utility of these classes was maintained when controlling for multiple other established risk factors for depressive disorders. This work highlights the utility of examining multiple factors simultaneously to understand risk for depression.

Concurrent and Prospective Associations between Metacognition and Depression in Adolescents

Background: Addressing one’s metacognitive beliefs is a relatively new, yet promising approach in the treatment of adolescent depression. However, multiple aspects of metacognition can be found in cognitive measures that were created prior to this recent focus. Objectives: The current study leveraged data collected from the Oregon Adolescent Depression Project (OADP) to address a series of questions regarding the associations between metacognitions and adolescent depression. Methods: Participants included 1,709 community-residing adolescents who were diagnostically assessed on four occasions between the ages of 16 and 30. A construct of metacognition was developed from the battery of assessments in the OADP, following the model established by pioneering metacognitive researcher Adrian Wells. Confirmatory factor analysis demonstrated an acceptable model fit of a four-indicant metacognition construct based on four measures that assessed worry, self-consciousness, self-reinforcement, and mastery. Results: The metacognition construct was highly correlated with concurrent depression symptoms, with significantly greater associations for female versus male adolescents. Conversely, higher levels of dysfunctional metacognitions in adolescence were predictive of a first incidence of major depressive disorder in emerging adulthood for male but not for female adolescents. Conclusion: Study findings suggest that therapies that address metacognitive beliefs may be particularly effective in treating depression, especially for female adolescents. In addition, this study indicates metacognition might act as a key marker for identifying youth at risk for the onset of major depressive disorder in emerging adulthood, especially amongst male adolescents.

Natural course of cannabis use disorders.

Despite its importance as a public health concern, relatively little is known about the natural course of cannabis use disorders (CUDs). The primary objective of this research was to provide descriptive data on the onset, recovery and recurrence functions of CUDs during the high-risk periods of adolescence, emerging adulthood and young adulthood based on data from a large prospective community sample. Probands (n = 816) from the Oregon Adolescent Depression Project (OADP) participated in four diagnostic assessments (T1-T4) between the ages of 16 and 30 years, during which current and past CUDs were assessed. The weighted lifetime prevalence of CUDs was 19.1% with an average onset age of 18.6 years. Although gender was not significantly related to the age of initial CUD onset, men were more likely to be diagnosed with a lifetime CUD. Of those diagnosed with a CUD episode, 81.8% eventually achieved recovery during the study period. Women achieved recovery significantly more quickly than men. The recurrence rate (27.7%) was relatively modest, and most likely to occur within the first 36 months following the offset of the first CUD episode. CUD recurrence was uncommon after 72 months of remission and recovery. CUDs are relatively common, affecting about one out of five persons in the OADP sample prior to the age of 30 years. Eventual recovery from index CUD episodes is the norm, although about 30% of those with a CUD exhibit a generally persistent pattern of problematic use extending 7 years or longer.

Aggregation of lifetime Axis I psychiatric disorders through age 30: incidence, predictors, and associated psychosocial outcomes.

Longitudinal data from representative birth cohorts on the aggregation of psychiatric disorders, or the cumulative number of unique diagnosed disorders experienced by persons within a circumscribed period, are limited. As a consequence, risk factors for and psychosocial implications of lifetime disorder aggregation in the general population remain largely unknown. This research evaluates the incidence, predictors, and psychosocial sequela of lifetime disorder aggregation from childhood through age 30. Over a 14-year period, participants in the Oregon Adolescent Depression Project (probands; N = 816) were repeatedly evaluated for psychiatric disorders and assessed with multiple measures of psychosocial functioning. First-degree relatives of probands (N = 2,414) were also interviewed to establish their lifetime psychiatric history. The cumulative prevalence of common lifetime psychiatric disorders for the proband sample was 71%. Three-quarters of all proband psychiatric disorders occurred among 37% of the sample, and 82% of all disorder diagnoses were made among persons who met criteria for at least one other lifetime disorder. Lifetime disorder aggregation in probands was predicted by lifetime psychiatric disorder densities among first-degree relatives and was related to heterotypic comorbidity patterns that included disorders from both internalizing and externalizing domains, most notably major depressive and alcohol use disorders. By age 30, disorder aggregation was significantly associated with mental health care service utilization and predictive of personality disorder pathology and numerous indicators of poor psychosocial functioning. Possible implications of disorder aggregation on the conceptualization of lifetime psychiatric disorder comorbidity are discussed.

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN ADOLESCENCE PREDICTS ONSET OF MAJOR DEPRESSIVE DISORDER THROUGH EARLY ADULTHOOD

The aim of this study was to examine the prospective relationship between a history of attention-deficit/hyperactivity disorder (ADHD) assessed in mid-adolescence and the onset of major depressive disorder (MDD) through early adulthood in a large school-based sample. A secondary aim was to examine whether this relationship was robust after accounting for comorbid psychopathology and psychosocial impairment. One thousand five hundred seven participants from the Oregon Adolescent Depression Project completed rating scales in adolescence and structured diagnostic interviews up to four times from adolescence to age 30. Adolescents with a lifetime history of ADHD were at significantly higher risk of MDD through early adulthood relative to those with no history of ADHD. ADHD remained a significant predictor of MDD after controlling for gender, lifetime history of other psychiatric disorders in adolescence, social and academic impairment in adolescence, stress and coping in adolescence, and new onset of other psychiatric disorders through early adulthood (hazard ratio, 1.81; 95% confidence interval, 1.04, 3.06). Additional significant, robust predictors of MDD included female gender, a lifetime history of an anxiety disorder, and poor coping skills in mid-adolescence, as well as the onset of anxiety, oppositional defiant disorder, and substance-use disorder after mid-adolescence. A history of ADHD in adolescence was associated with elevated risk of MDD through early adulthood and this relationship remained significant after controlling for psychosocial impairment in adolescence and co-occurring psychiatric disorders. Additional work is needed to identify the mechanisms of risk and to inform depression prevention programs for adolescents with ADHD.

Predictors of first lifetime onset of major depressive disorder in young adulthood.

The first onset of major depressive disorder (MDD) most frequently occurs in young adulthood. However, few studies have examined predictors of first lifetime MDD during this high-risk period. The present study examined a broad range of demographic, clinical, and psychosocial variables as prospective predictors of first onset of MDD in a large community sample of young adults (N = 502) from the Oregon Adolescent Depression Project. Between ages 19-31, 35.3% of the sample had a first lifetime MDD episode. Female gender, familial loading of mood disorders, history of childhood sexual abuse, prior history of anxiety disorder, poor self-reported physical health, and subthreshold depressive symptoms significantly predicted MDD onset. In a multivariate model, female gender, familial loading of mood disorders, and subthreshold depression each contributed unique variance in predicting first lifetime MDD. This model had a moderate-to-large effect in predicting MDD onset. Gender did not moderate the other predictors, and the magnitude of the effects did not diminish over the course of the follow-up. These findings indicate that a number of risk factors significantly predict first lifetime MDD in young adulthood, and that simple multivariate risk models may be useful for identifying individuals at high risk for MDD.

Key Characteristics of Major Depressive Disorder Occurring in Childhood, Adolescence, Emerging Adulthood, Adulthood.

This paper summarizes characteristics of major depressive disorder (MDD) in the Oregon Adolescent Depression Project, using data from 816 participants (56% female; 89% White). Contrasting four developmental periods (Childhood [5-12.9], Adolescence [13-17.9], Emerging Adulthood [18-23.9], Adulthood [24-30]), we examine MDD incidence/recurrence, gender, comorbidity, duration, and suicide attempts across periods. MDD first incidence was lower in Childhood compared to subsequent periods, and higher in Emerging Adulthood than Adulthood. Cumulative incidence was 51%. Recurrence was lower during Childhood than remaining periods, which were comparable. Female gender predicted first incident MDD in all four periods but was unassociated with recurrence. Comorbidity rates were comparable across periods. MDD duration was greater in Childhood than remaining periods. Suicide attempt rates were significantly higher during Adolescence than either Emerging Adulthood or Adulthood. Depression research should focus on MDD during Emerging Adulthood, adolescent suicidal behavior, the continuing role of gender into adulthood, and the ubiquity of MDD.

Disentangling the Temporal Relationship Between Parental Depressive Symptoms and Early Child Behavior Problems: A Transactional Framework

Despite the considerable amount of research demonstrating the relationship between parental depressive symptoms and child behavior problems, few studies have examined the direction of the relationship between these variables. Therefore, the purpose of this study was to examine transactional effects between parental depressive symptoms and child behavior problems. Participants were 209 parent–child dyads drawn from the Oregon Adolescent Depression Project who completed at least 2 of 4 annual questionnaire assessments between the child's age of 4 and 7 years. Structural equation modeling was used to examine the autoregressive paths from one year to the next year within each construct, as well as cross-lagged paths from one year to the next year between constructs. Findings indicated that parental depressive symptoms at each year predicted child behavior problems at the subsequent year and vice versa. No support was found for differential gender effects. These findings highlight the reciprocal relationship between parental depressive symptoms and child behavior problems and suggest intervention programs for young children should assess for and target parental depression when appropriate. Future research should examine these relationships across a broader developmental spectrum and in more diverse, heterogeneous samples.

The moderating effect of parental illicit substance use disorders on the relation between adolescent depression and subsequent illicit substance use disorders

BackgroundPrevious research has demonstrated that depression and family history of illicit substance use disorders (ISUDs) are risk factors for the development of ISUDs. However, no study to date has examined whether these risk factors interact to predict onset. In addition, history of parental and sibling ISUDs have been identified as risk factors almost exclusively in healthy individuals and thus, it is unknown whether they confer unique risk among adolescents with a history of depression. MethodsThe current study examined these questions using data from the Oregon Adolescent Depression Project (OADP). DSM diagnoses of probands were assessed during 4-waves, first in adolescence (ages 14–18) and subsequently up until age 30. Lifetime DSM diagnoses of ISUDs in biological mothers, fathers, and siblings were obtained. ResultsProportional hazards model analyses indicated that there was a significant depression by parental ISUDs interaction. Among probands with parental ISUDs (and not among those without parental ISUDs), depression in adolescence was significantly associated with a shorter time to develop an ISUD. Sibling ISUDs were not associated with onset and did not interact with adolescent depression. ConclusionPrevention and intervention efforts targeted at this particularly at-risk group may be effective.

Lifetime rates of psychopathology in single versus multiple diagnostic assessments: Comparison in a community sample of probands and siblings

Lifetime prevalence rates of psychopathology vary a great deal depending on whether they are estimated from cross-sectional or prospective longitudinal studies, with the former yielding significantly lower rates. Such findings, however, come from comparisons of separate studies from different countries and cohorts. Here, we compare lifetime rates of psychopathology between a community sample of individuals assessed on multiple occasions to their siblings who completed only a single diagnostic evaluation. Data come from the Oregon Adolescent Depression Project. We included 442 original participants who completed four prospective diagnostic assessments over the course of fifteen years, and 657 of their siblings who completed a single lifetime assessment. Comparisons of rates of depressive, bipolar, anxiety, and substance use disorders were made using survival analysis. We found that rates of depressive disorders, specifically major depressive disorder, were elevated among individuals who completed multiple diagnostic assessments relative to individuals who completed a single lifetime assessment. We did not find significant differences in rates of aggregate anxiety, bipolar, or substance use disorders. Within a single cohort, cross-sectional surveys appear to underestimate the lifetime rates of major depression relative to prospective, longitudinal designs. This suggests that disorders with an episodic course may be under-reported in cross-sectional surveys. Rates of anxiety, bipolar, and substance use disorders did not differ across assessment methods. To further evaluate method effects on lifetime estimates of psychopathology, future work may benefit from comparing rates of retrospectively- and prospectively-derived diagnoses in individuals who are repeatedly assessed over a lengthy follow-up period.

Examination of the structure of psychopathology using latent class analysis

Several recent studies using factor analytic methods find that the structure of psychopathology reflects broad internalizing and externalizing dimensions, with the internalizing dimension being further divided into fear and distress disorders. Although these variable-centered studies have provided important insights into the structure of psychopathology, they provide limited information about the classification of individual cases. The present study examines patterns of lifetime internalizing and externalizing psychopathology in participants from the Oregon Adolescent Depression Project using latent class analysis that classifies individuals rather than variables. A 4-class solution best fits the data. The largest class (62.5%) included individuals with relatively little psychopathology; 1 class (16.4%) was largely characterized by internalizing disorders, 1 class (16.9%), largely characterized by externalizing disorders; and the final class (4.2%), characterized by both internalizing and externalizing disorders. The validity of the classes was further examined using data on psychiatric morbidity, temperament, and family aggregation of psychopathology. Classes differed on indices of positive, negative, and disinhibited temperament in ways that were consistent with theoretical predictions. Patterns of familial aggregation of psychopathology demonstrated relative specificity of transmission of different disorders. Overall, the findings support conclusions from studies of dimensional models of internalizing and externalizing disorders, and extend them to person-centered approaches to classification.

Familial influence of substance use disorder on emotional disorder across three generations

The concomitant influence of grandparental (Generation 1; G1) and parental (G2) substance use disorder (SUD) on grandchild (G3) emotional disorder (EmD) across three generations is unclear. The present study addressed this in a sample of 284 families participating in the Oregon Adolescent Depression Project. Structured clinical interviews were used to collect psychiatric history data on a community cohort of G2 individuals and their G1 parents. G2 parents rated EmD symptoms in their G3 children ( M age = 5 years, SD = 2.4). Results indicated that G1 SUD was associated with increased risk of G3 EmD symptom elevations, above and beyond the influence of comorbid G1 EmD. G2 SUD was associated with a similar independent increase in risk for G3 EmD symptoms. Also, G1 SUD conferred risk for G2 SUD. Mediational tests indicated that the influence of G1 SUD on G3 EmD was transmitted via its influence on G2 SUD. G1 and G2 SUD did not interact in predicting G3 EmD; rather results suggested an additive influence. There was no evidence that the influence of G1 SUD on G3 EmD was transmitted via G2 EmD. These findings shed light on the multigenerational processes through which SUD influences EmD.

Gender differences in the developmental course of depression

Background There is ample evidence for female preponderance of major depressive disorder (MDD) in adolescence and adulthood. This study examined gender differences in the developmental course (i.e., incidence, duration, number of depressive episodes, and recovery rates) of MDD in non-referred adolescents and young adults. Methods Data from the Oregon Adolescent Depression Project were used to examine gender differences in the developmental course of MDD. Gender differences in the onset, duration, number of depressive episode and rate of recovery from MDD were examined in a population-based sample of the same individuals (participants: N = 773) during adolescence (age 14 to 17) and at age 30. Results Compared to males, females have higher incidence rates of MDD and had a more chronic course. Difference in duration of depressive episodes is marginally significant between male and female, with females having longer episodes. Lower onset age correlates significantly with more number of episodes in both genders; however, lower onset age predicts a worse course of depression only in females. Limitations The sample was from a single region of the country and consisted mostly of White adolescents. Conclusions Childhood depression may be a more serious risk factor for girls than for boys.

Effect of Maternal Depression on Child Behavior: A Sensitive Period?

The purpose of this study was to examine the effect of maternal depression during the child's first year of life (i.e., sensitive period) on subsequent behavior problems. Participants were 175 mothers participating in the Oregon Adolescent Depression Project (OADP) who met lifetime diagnostic criteria for major depressive disorder (MDD) and completed the child behavior checklist (CBCL) for their first child at some point during the child's first 12 years (mean = 4.91 years). Regression analyses indicated that MDD in the sensitive period was a significant predictor of internalizing and total behavior problems on the CBCL while controlling for several demographic variables (e.g., child and mother age, child gender). Maternal depression before pregnancy and during the prenatal period did not significantly predict later child behavior problems, suggesting that the effect was not driven by the presence of previous MDD and was specific to the first year of life. Presence of maternal MDD during a child's first year of life represents a sensitive period and increases the risk of adverse child outcome. The findings suggest the importance of identification, prevention, and early intervention. Future studies should examine these findings in more diverse, heterogeneous samples.

Delineation of differential temporal relations between specific eating and anxiety disorders

This study examined the temporal sequencing of eating and anxiety disorders to delineate which anxiety disorders increase eating disorder risk and whether individuals with eating disorders are at greater risk for particular anxiety disorders. The sample was drawn from the Oregon Adolescent Depression Project. Temporal relations between specific eating and anxiety disorders were examined after controlling for relevant variables (e.g., mood disorders, other anxiety disorders) over 14 years. After excluding those with anorexia nervosa (AN) in adolescence (T1), OCD was the only T1 anxiety disorder to predict AN by age 30 (T4). No T1 anxiety disorder was associated with T4 bulimia nervosa (BN). Although T1 AN did not increase risk of any T4 anxiety disorder, T1 BN appeared to increase risk for social anxiety and panic disorders. Evidence that eating disorders may have differential relations to particular anxiety disorders could inform prevention and treatment efforts.