The study on granular flow characteristics of ore-rock and its influencing factors is significant for controlling ore dilution-loss. With the reference of predecessor’s research achievements, isolation layer thickness, friction coefficient of isolation layer interface, particle friction coefficient, particle radius and wall friction coefficient are considered as main influence factors. The orthogonal ore drawing numerical model, which contains four factors and three levels, is established with orthogonal test. The flow characteristics in ore drawing from multiple funnels under flexible isolation layer is explored through the simulation on ore-rock flow law in ore drawing from multiple funnel. Combined with the test characteristics of ore drawing from multiple funnels, the ratio of drawing quantity to intersecting line height of drawing ore body and undulating angle of isolation layer are chosen as evaluating indicators. Weight matrix of index system is obtained and action law of influencing factors is elucidated with the use of matrix analysis. The study results show that the drawing ore body is not a regular ellipsoid in ore drawing from multiple funnels due to the varying degrees variation, e.g., interleaving and deletion caused by interplay between each drawing holes. The isolation layer interface drops at a approximate level at early stage of ore drawing and later at a circular-arc. At the end of the ore drawing, isolation layer suspends in the bottom structure, showing a wave shape. The movement pattern of the isolated layer plays an important role in the effect of ore drawing. The effect weights ranking of each factor is wall friction coefficient, particle friction coefficient, particle radius, interface friction coefficient and isolation layer thickness. The best flowing effects of ore happens when wall friction coefficient is 0.2, particle friction coefficient is 0.8, particle radius is 0.008 m, interface friction coefficient is 0.8 and isolation layer thickness is 0.005 m.